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Synergistic inhibition of avian leukosis virus subgroup J replication by miRNA-embedded siRNA interference of double-target
Conclusions: These data demonstrated that the miRNA-embedded siRNA interference is an efficient method for inhibition of ALV-J replication, especially double targets.
Source: Epidemiologic Perspectives and Innovations - March 21, 2015 Category: Epidemiology Authors: Rongrong WeiXiaoqian MaGuihua WangHuijun GuoJianzhu LiuLingxiao FanZiqiang Cheng Source Type: research

Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma
Conclusions: Our results illustrate a little-studied mechanism of immune escape by tumor cells which, with appropriate understanding and treatment, may be reversible. These data have implications for the design of cancer vaccines and adoptive T cell therapies.
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Katherine WoodsAshley J. KnightsMatthew AnakaRalf SchittenhelmAnthony PurcellAndreas BehrenJonathan Cebon Source Type: research

Unsaturated, Trialkyl Ionizable Lipids are Versatile LNP Components for Therapeutic and Vaccine Applications
This article is protected by copyright. All rights reserved.PMID:36680477 | DOI:10.1002/adma.202209624
Source: Adv Data - January 21, 2023 Category: Epidemiology Authors: Kieu Lam Ada Leung Alan Martin Mark Wood Petra Schreiner Lorne Palmer Owen Daly Wenchen Zhao Kevin McClintock James Heyes Source Type: research

Optimizing Lipid Nanoparticles for Delivery in Primates
This article is protected by copyright. All rights reserved.PMID:36972555 | DOI:10.1002/adma.202211420
Source: Adv Data - March 27, 2023 Category: Epidemiology Authors: Kieu Lam Petra Schreiner Ada Leung Paul Stainton Steve Reid Ed Yaworski Pete Lutwyche James Heyes Source Type: research