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Specialty: Biotechnology
Procedure: Skin Biopsy
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Fluorescent peptide biosensor for monitoring CDK4/cyclin D kinase activity in melanoma cell extracts, mouse xenografts and skin biopsies
Publication date: 15 November 2016 Source:Biosensors and Bioelectronics, Volume 85 Author(s): Camille Prével, Morgan Pellerano, Juan A. González-Vera, Pauline Henri, Laurent Meunier, Julien Vollaire, Véronique Josserand, May C. Morris Melanoma constitutes the most aggressive form of skin cancer, which further metastasizes into a deadly form of cancer. The p16INK4a-Cyclin D-CDK4/6-pRb pathway is dysregulated in 90% of melanomas. CDK4/Cyclin D kinase hyperactivation, associated with mutation of CDK4, amplification of Cyclin D or loss of p16INK4a leads to increased risk of developing melanoma. This kinase therefo...
Source: Biosensors and Bioelectronics - May 17, 2016 Category: Biotechnology Source Type: research
