Filtered By:
Specialty: Opthalmology

This page shows you your search results in order of relevance. This is page number 8.

Order by Relevance | Date

Total 178 results found since Jan 2013.

MRP4-Mediated Regulation of Intracellular cAMP and cGMP Levels in Trabecular Meshwork Cells and Homeostasis of Intraocular Pressure Physiology and Pharmacology
Conclusions. These observations reveal that cyclic nucleotide efflux controlling transporter-MRP4 plays a significant role in IOP homeostasis potentially by regulating the relaxation characteristics of AH outflow pathway cells.
Source: Investigative Ophthalmology - March 5, 2013 Category: Opthalmology Authors: Pattabiraman, P. P., Pecen, P. E., Rao, P. V. Tags: Physiology and Pharmacology Source Type: research

MicroRNA-124a Is Epigenetically Regulated and Acts as a Tumor Suppressor by Controlling Multiple Targets in Uveal Melanoma Biochemistry and Molecular Biology
Conclusions. Our results demonstrated that miR-124a could function as a potent tumor suppressor by regulation of multiple targets, and was epigenetically silenced in the development of uveal melanoma.
Source: Investigative Ophthalmology - March 27, 2013 Category: Opthalmology Authors: Chen, X., He, D., Dong, X. D., Dong, F., Wang, J., Wang, L., Tang, J., Hu, D.-N., Yan, D., Tu, L. Tags: Biochemistry and Molecular Biology Source Type: research

Epithelial Membrane Protein 2 Controls VEGF Expression in ARPE-19 Cells Retinal Cell Biology
Conclusions. This study establishes a novel connection between EMP2 and VEGF and may reflect either a direct effect through the tetraspan web or an indirect change through FAK activation. This connection is functionally significant. In addition to the direct use of anti-VEGF antibodies, modulation of EMP2 with impact on VEGF is potentially a distinct therapeutic target for the treatment of neovascularization associated with retinal diseases that involve pathologic angiogenesis.
Source: Investigative Ophthalmology - March 28, 2013 Category: Opthalmology Authors: Morales, S. A., Telander, D. G., Leon, D., Forward, K., Braun, J., Wadehra, M., Gordon, L. K. Tags: Retinal Cell Biology Source Type: research

DNA-PK Phosphorylation of IGFBP-3 Is Required to Prevent Apoptosis in Retinal Endothelial Cells Cultured in High Glucose Retina Cell Biology
Conclusions. Our findings suggest Compound 49b induces DNA-PK levels through PKA activity. DNA-PK is required for Compound 49b–induced IGFBP-3 expression, leading to inhibition of REC cell death.
Source: Investigative Ophthalmology - April 30, 2013 Category: Opthalmology Authors: Zhang, Q., Steinle, J. J. Tags: Retina Cell Biology Source Type: research

TREM-2 Promotes Host Resistance Against Pseudomonas aeruginosa Infection by Suppressing Corneal Inflammation via a PI3K/Akt Signaling Pathway Immunology and Microbiology
Conclusions. TREM-2 promoted host resistance to PA infection by suppressing corneal inflammation via activation of the PI3K/Akt pathway.
Source: Investigative Ophthalmology - May 17, 2013 Category: Opthalmology Authors: Sun, M., Zhu, M., Chen, K., Nie, X., Deng, Q., Hazlett, L. D., Wu, Y., Li, M., Wu, M., Huang, X. Tags: Immunology and Microbiology Source Type: research

Modulation of Bevacizumab-Induced Toxicity for Cultured Human Corneal Fibroblasts Cornea
Conclusions. This study determined the cellular toxicity of bevacizumab and its modulation with bFGF or NGF. Cotreatment with bFGF or NGF with bevacizumab reduced cellular damage without interfering with the original antiangiogenic function. Some components of serum have a protective effect on bevacizumab-induced corneal epithelial change.
Source: Investigative Ophthalmology - June 6, 2013 Category: Opthalmology Authors: Kim, E. K., Kang, S. W., Kim, J. Y., Min, K., Kim, T.-i. Tags: Cornea Source Type: research

Transcription Factor Nrf2-Mediated Antioxidant Defense System in the Development of Diabetic Retinopathy Retinal Cell Biology
Conclusions. Due to increased binding of Nrf2 with Keap1, its translocation to the nucleus is compromised contributing to the decreased GSH levels. Thus, regulation of Nrf2-Keap1 by pharmacological or molecular means could serve as a potential adjunct therapy to combat oxidative stress and inhibit the development of diabetic retinopathy.
Source: Investigative Ophthalmology - June 6, 2013 Category: Opthalmology Authors: Zhong, Q., Mishra, M., Kowluru, R. A. Tags: Retinal Cell Biology Source Type: research

Laser-Induced Choroidal Neovascularization in Mice Attenuated by Deficiency in the Apelin-APJ System Biochemistry and Molecular Biology
Conclusions. The results suggested that the apelin-APJ system contributes to CNV development partially independent of the VEGF pathway.
Source: Investigative Ophthalmology - June 21, 2013 Category: Opthalmology Authors: Hara, C., Kasai, A., Gomi, F., Satooka, T., Sakimoto, S., Nakai, K., Yoshioka, Y., Yamamuro, A., Maeda, S., Nishida, K. Tags: Biochemistry and Molecular Biology Source Type: research

Activated {alpha}v{beta}3 Integrin Regulates {alpha}v{beta}5 Integrin-Mediated Phagocytosis in Trabecular Meshwork Cells Glaucoma
Conclusions. The αvβ5 integrin-FAK–mediated pathway regulates phagocytosis in TM cells and this pathway is inhibited by activation of αvβ3 integrins. This suggests that changes in integrin expression and activity may be responsible for alterations in phagocytosis observed in steroid induced glaucoma.
Source: Investigative Ophthalmology - July 24, 2013 Category: Opthalmology Authors: Gagen, D., Filla, M. S., Clark, R., Liton, P., Peters, D. M. Tags: Glaucoma Source Type: research

Regulation of Cdc42 Expression and Signaling Is Critical for Promoting Corneal Epithelial Wound Healing Cornea
Conclusions. Cdc42 is an important regulator of corneal epithelial wound repair. To promote healing, Cdc42 may interact with receptor tyrosine kinase–activated signaling cascades that participate in cell migration and cell-cycle progression.
Source: Investigative Ophthalmology - August 9, 2013 Category: Opthalmology Authors: Pothula, S., Bazan, H. E. P., Chandrasekher, G. Tags: Cornea Source Type: research

Novel Quinic Acid Derivative KZ-41 Prevents Retinal Endothelial Cell Apoptosis Without Inhibiting Retinoblastoma Cell Death Through p38 Signaling Translational
Conclusions. KZ-41 protects REC against melphalan-induced upregulation of ICAM-1 and apoptosis through p38 MAPK–dependent pathways.
Source: Investigative Ophthalmology - September 3, 2013 Category: Opthalmology Authors: Zhang, Q., Jiang, Y., Toutounchian, J., Wilson, M. W., Morales-Tirado, V., Miller, D. D., Yates, C. R., Steinle, J. J. Tags: Translational Source Type: research

Inhibitory Effect of MicroRNA-34a on Retinal Pigment Epithelial Cell Proliferation and Migration Retinal Cell Biology
Conclusions. MicroRNA-34a is downregulated in subconfluent RPE cells. MicroRNA-34a can inhibit the proliferation and migration of RPE cells through downregulation of its targets c-Met and other cell cycle–related molecules. Our results indicated that miR-34a is involved in the regulation of RPE cells.
Source: Investigative Ophthalmology - October 3, 2013 Category: Opthalmology Authors: Hou, Q., Tang, J., Wang, Z., Wang, C., Chen, X., Hou, L., Dong, X. D., Tu, L. Tags: Retinal Cell Biology Source Type: research

Endogenous IgG Affects the Cell Biology of RPE Cells and Involves the TLR4 Pathway Immunology and Microbiology
Conclusions. These data suggest that endogenous IgG may be a molecule that is essential for the physiological function of RPE, and suggest IgG is important for regulating intraocular immune responses under physiologic and pathologic conditions.
Source: Investigative Ophthalmology - October 25, 2013 Category: Opthalmology Authors: Niu, N., Zhang, J., McNutt, M. A. Tags: Immunology and Microbiology Source Type: research

Inhibition of Polo-Like Kinase 1 Promotes Hyperthermia Sensitivity via Inactivation of Heat Shock Transcription Factor 1 in Human Retinoblastoma Cells New Developments
Conclusions. Polo-like kinase 1 inhibition may attenuate the thermoresistance of HT through the inactivation of HSF1 concomitant with reductions in HSPs and BAG3. The combination of PLK1 inhibition and HT may become an option for HT therapy in patients with retinoblastoma.
Source: Investigative Ophthalmology - December 23, 2013 Category: Opthalmology Authors: Yunoki, T., Tabuchi, Y., Hayashi, A., Kondo, T. Tags: New Developments Source Type: research

Aldose Reductase Inhibition Prevents Endotoxin-Induced Inflammatory Responses in Retinal Microglia Retinal Cell Biology
Conclusions. These results demonstrate that the action of AR contributes to the activation of RMG. Inhibition of AR may be a therapeutic strategy to reduce inflammation associated with activation of RMG in disease.
Source: Investigative Ophthalmology - May 2, 2014 Category: Opthalmology Authors: Chang, K.-C., Ponder, J., LaBarbera, D. V., Petrash, J. M. Tags: Retinal Cell Biology Source Type: research