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Temporal Association Between Ischemic Muscle Perfusion Recovery and the Restoration of Muscle Contractile Function After Hindlimb Ischemia
We examined this relationship in BALB/cJ mice (N=24) following unilateral hindlimb ischemia (HLI). Specifically, we examined this relationship in two phenotypically distinct muscles (i.e. ‘oxidative’ soleus - Sol and ‘glycolytic’ extensor digitorum longus - EDL) 14- or 56-days after HLI. Although overall limb blood flow (LDPI) reached its’ recovery peak (48% of control) by HLI d14, the capillary networks in both the Sol and EDL (whole mount confocal imaging) were disrupted and competent muscle capillary perfusion (perfused lectin+ μm2 / muscle μm2) remained reduced. Interestingly, both Sol and EDL muscles recov...
Source: Frontiers in Physiology - June 27, 2019 Category: Physiology Source Type: research