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Mitochondria: Role of citrulline and arginine supplementation in MELAS syndrome.
Abstract Mitochondria are found in all nucleated human cells and generate most of the cellular energy. Mitochondrial disorders result from dysfunctional mitochondria that are unable to generate sufficient ATP to meet the energy needs of various organs. Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a frequent maternally inherited mitochondrial disorder. There is growing evidence that nitric oxide (NO) deficiency occurs in MELAS syndrome and results in impaired blood perfusion that contributes significantly to several complications including stroke-like episodes, myop...
Source: The International Journal of Biochemistry and Cell Biology - January 8, 2014 Category: Biochemistry Authors: El-Hattab AW, Emrick LT, Chanprasert S, Craigen WJ, Scaglia F Tags: Int J Biochem Cell Biol Source Type: research