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Relationship between glucocorticoid dose and adverse events in systemic lupus erythematosus: data from a randomized clinical trial.
CONCLUSION: This study highlights the feasibility of post-hoc analyses of RCTs using the SHARE mechanism and demonstrates the association of GCs with various AEs. Contrary to expectations, there were also associations between lower cumulative GC dose and several other AEs. PMID: 28862513 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - September 1, 2017 Category: Rheumatology Authors: Emamikia S, Gentline C, Chatzidionysiou K, Arnaud L, van Vollenhoven R Tags: Scand J Rheumatol Source Type: research

Hydroxychloroquine inhibits proinflammatory signalling pathways by targeting endosomal NADPH oxidase
Conclusions We describe here a novel mechanism of action of HCQ, that is, interference with the assembly of endosomal NOX2. Since endosomal NOX2 is involved in many inflammatory and prothrombotic signalling pathways, this activity of HCQ might explain many of its beneficial effects in rheumatic diseases including the APS.
Source: Annals of the Rheumatic Diseases - April 6, 2017 Category: Rheumatology Authors: Müller-Calleja, N., Manukyan, D., Canisius, A., Strand, D., Lackner, K. J. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Systemic lupus erythematosus, Clinical diagnostic tests Basic and translational research Source Type: research

Increased arterial wall inflammation in patients with ankylosing spondylitis is reduced by statin therapy
Conclusions Patients with AS and without other CVD risk factors have increased arterial wall inflammation, which decreases upon statin therapy. These subjects are not identified as being at risk in current cardiovascular prevention guidelines. Our data support the need to revise CV disease management in AS, with perhaps a role for early statin therapy.
Source: Annals of the Rheumatic Diseases - September 8, 2016 Category: Rheumatology Authors: van der Valk, F. M., Bernelot Moens, S. J., Verweij, S. L., Strang, A. C., Nederveen, A. J., Verberne, H. J., Nurmohamed, M. T., Baeten, D. L., Stroes, E. S. G. Tags: Immunology (including allergy), Inflammation, Radiology, Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics), Calcium and bone Source Type: research

Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS)
Conclusions Childhood cancer survivors are at increased risk for certain types of autoimmune diseases. These findings underscore the need for prolonged follow-up of these survivors.
Source: Annals of the Rheumatic Diseases - August 9, 2016 Category: Rheumatology Authors: Holmqvist, A. S., Olsen, J. H., Mellemkjaer, L., Garwicz, S., Hjorth, L., Moëll, C., Mansson, B., Tryggvadottir, L., Hasle, H., Winther, J. F., on behalf of the ALiCCS study group Tags: Press releases, Immunology (including allergy), Renal medicine, Vascularitis, Health economics Clinical and epidemiological research Source Type: research

Circulating cartilage oligomeric matrix protein in juvenile idiopathic arthritis.
CONCLUSIONS: The results of this study do not support routine clinical analysis of sCOMP levels in patients with JIA. PMID: 27385219 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - July 5, 2016 Category: Rheumatology Authors: Lewander P, Dahle C, Larsson B, Wetterö J, Skogh T Tags: Scand J Rheumatol Source Type: research

MRI assessment of suppression of structural damage in patients with rheumatoid arthritis receiving rituximab: results from the randomised, placebo-controlled, double-blind RA-SCORE study
Conclusions This study demonstrated that rituximab significantly reduced erosion and cartilage loss at week 24 and week 52 in MTX-inadequate responder patients with active RA, suggesting that MRI is a valuable tool for assessing inflammatory and structural damage in patients with established RA receiving rituximab. Trial registration number NCT00578305
Source: Annals of the Rheumatic Diseases - December 11, 2015 Category: Rheumatology Authors: Peterfy, C., Emery, P., Tak, P. P., Ostergaard, M., DiCarlo, J., Otsa, K., Navarro Sarabia, F., Pavelka, K., Bagnard, M.-A., Gylvin, L. H., Bernasconi, C., Gabriele, A. Tags: Open access, Immunology (including allergy), Bone and joint infections, Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics), Ca Source Type: research

Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis
Conclusions S100A8/A9 aggravate osteophyte formation in experimental OA with high synovial activation and may be used to predict osteophyte progression in early symptomatic human OA.
Source: Annals of the Rheumatic Diseases - December 11, 2015 Category: Rheumatology Authors: Schelbergen, R. F. P., de Munter, W., van den Bosch, M. H. J., Lafeber, F. P. J. G., Sloetjes, A., Vogl, T., Roth, J., van den Berg, W. B., van der Kraan, P. M., Blom, A. B., van Lent, P. L. E. M. Tags: Immunology (including allergy), Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Epidemiology Basic and translational research Source Type: research

Additive effect of anti-citrullinated protein antibodies and rheumatoid factor on bone erosions in patients with RA
Conclusions ACPAs and RF show an additive effect on erosion number and erosion size. Concomitant presence of ACPAs and RF is associated with higher erosive disease burden in patients with RA. Furthermore, RF influences erosion size only in ACPA-positive but not in ACPA-negative patients.
Source: Annals of the Rheumatic Diseases - November 10, 2015 Category: Rheumatology Authors: Hecht, C., Englbrecht, M., Rech, J., Schmidt, S., Araujo, E., Engelke, K., Finzel, S., Schett, G. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

EULAR-PReS points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice
To develop evidence based points to consider the use of imaging in the diagnosis and management of juvenile idiopathic arthritis (JIA) in clinical practice. The task force comprised a group of paediatric rheumatologists, rheumatologists experienced in imaging, radiologists, methodologists and patients from nine countries. Eleven questions on imaging in JIA were generated using a process of discussion and consensus. Research evidence was searched systematically for each question using MEDLINE, EMBASE and Cochrane CENTRAL. Imaging modalities included were conventional radiography, ultrasound, MRI, CT, scintigraphy and positr...
Source: Annals of the Rheumatic Diseases - October 9, 2015 Category: Rheumatology Authors: Colebatch-Bourn, A. N., Edwards, C. J., Collado, P., D'Agostino, M.-A., Hemke, R., Jousse-Joulin, S., Maas, M., Martini, A., Naredo, E., Ostergaard, M., Rooney, M., Tzaribachev, N., van Rossum, M. A., Vojinovic, J., Conaghan, P. G., Malattia, C. Tags: Immunology (including allergy), Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Recommendation Source Type: research

Candidate lesion-based criteria for defining a positive sacroiliac joint MRI in two cohorts of patients with axial spondyloarthritis
Conclusions Lesion-based criteria for a positive SIJ MRI based on both BMO and/or erosion performed best for classification of axial SpA, reflecting the contextual information provided by T1SE and STIR sequences.
Source: Annals of the Rheumatic Diseases - October 9, 2015 Category: Rheumatology Authors: Weber, U., Ostergaard, M., Lambert, R. G. W., Pedersen, S. J., Chan, S. M., Zubler, V., Rufibach, K., Zhao, Z., Maksymowych, W. P. Tags: Immunology (including allergy), Pain (neurology), Ophthalmology, Radiology, Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics), Source Type: research

A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk
Conclusions The present genome-wide scan for CNVs associated with PsA risk has identified a new deletion associated with disease risk and which is also differential from PsC risk.
Source: Annals of the Rheumatic Diseases - September 9, 2015 Category: Rheumatology Authors: Julia, A., Pinto, J. A., Gratacos, J., Queiro, R., Ferrandiz, C., Fonseca, E., Montilla, C., Torre-Alonso, J. C., Puig, L., Perez Venegas, J. J., Fernandez Nebro, A., Fernandez, E., Munoz-Fernandez, S., Dauden, E., Gonzalez, C., Roig, D., Sanchez Carazo, Tags: Genetics, Immunology (including allergy), Degenerative joint disease, Musculoskeletal syndromes Clinical and epidemiological research Source Type: research

EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice
A taskforce comprised of an expert group of 21 rheumatologists, radiologists and methodologists from 11 countries developed evidence-based recommendations on the use of imaging in the clinical management of both axial and peripheral spondyloarthritis (SpA). Twelve key questions on the role of imaging in SpA were generated using a process of discussion and consensus. Imaging modalities included conventional radiography, ultrasound, magnetic resonance imaging, computed tomography (CT), positron emission tomography, single photon emission CT, dual-emission x-ray absorptiometry and scintigraphy. Experts applied research eviden...
Source: Annals of the Rheumatic Diseases - June 10, 2015 Category: Rheumatology Authors: Mandl, P., Navarro-Compan, V., Terslev, L., Aegerter, P., van der Heijde, D., D'Agostino, M. A., Baraliakos, X., Pedersen, S. J., Jurik, A. G., Naredo, E., Schueller-Weidekamm, C., Weber, U., Wick, M. C., Bakker, P. A. C., Filippucci, E., Conaghan, P. G., Tags: Immunology (including allergy), Inflammation, Radiology, Musculoskeletal syndromes, Osteoporosis, Clinical diagnostic tests, Radiology (diagnostics), Calcium and bone Recommendation Source Type: research

Systemic inflammation and cardiovascular risk factors predict rapid progression of atherosclerosis in rheumatoid arthritis
Conclusions Systemic inflammation and CV risk factors were associated with rapid IMT progression. CV risk factors may modify the role of systemic inflammation in determining IMT progression over time. Methotrexate and antitumour necrosis factor agents may influence IMT progression by reducing the effect of the systemic inflammation on the IMT.
Source: Annals of the Rheumatic Diseases - May 8, 2015 Category: Rheumatology Authors: del Rincon, I., Polak, J. F., O'Leary, D. H., Battafarano, D. F., Erikson, J. M., Restrepo, J. F., Molina, E., Escalante, A. Tags: Immunology (including allergy), Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Does spinal MRI add incremental diagnostic value to MRI of the sacroiliac joints alone in patients with non-radiographic axial spondyloarthritis?
Conclusions Combined spine and SIJ MRI added little incremental value compared with SIJ MRI alone for diagnosing patients with nr-axSpA and enhancing confidence in this diagnosis.
Source: Annals of the Rheumatic Diseases - May 8, 2015 Category: Rheumatology Authors: Weber, U., Zubler, V., Zhao, Z., Lambert, R. G., Chan, S. M., Pedersen, S. J., Ostergaard, M., Rufibach, K., Maksymowych, W. P. Tags: Immunology (including allergy), Pain (neurology), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and epidemiological research Source Type: research

The specificity of ultrasound-detected bone erosions for rheumatoid arthritis
Conclusions The presence of US-detected erosions is not specific for RA. However, larger erosions in selected joints, especially 2nd and 5rd MCP, 5th MTP joints and distal ulna, were highly specific for and predictive of RA.
Source: Annals of the Rheumatic Diseases - April 2, 2015 Category: Rheumatology Authors: Zayat, A. S., Ellegaard, K., Conaghan, P. G., Terslev, L., Hensor, E. M. A., Freeston, J. E., Emery, P., Wakefield, R. J. Tags: Genetics, Immunology (including allergy), Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological Source Type: research

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