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Adverse histological features in malignant colorectal polyps: a contemporary series of 239 cases
Conclusions Surgical resection should be recommended if ≥2 of these adverse histological features are present and may be warranted if one feature is present. A positive margin may require additional local resection but not necessarily surgery if no other adverse factors are present.
Source: Journal of Clinical Pathology - March 17, 2016 Category: Pathology Authors: Brown, I. S., Bettington, M. L., Bettington, A., Miller, G., Rosty, C. Tags: Endoscopy, Immunology (including allergy), Colon cancer, Intestinal cancer, Morbid anatomy / surgical pathology Original article Source Type: research

Histological findings in infants with Gastrointestinal food allergy are associated with specific gastrointestinal symptoms; retrospective review from a tertiary centre
Conclusions: Food allergy may occur in very young children and is difficult to diagnose. Since endoscopy in infants has significant risks, stratification of decision-making may be aided by symptoms. At least one mucosal biopsy demonstrated an abnormal finding in around half of cases in this selected population. Infants presenting with diarrhoea, PR bleeding, urticaria and irritability are most likely to demonstrate abnormal histological findings.
Source: BMC Clinical Pathology - June 16, 2015 Category: Pathology Authors: Neil ShahRu-Xin FoongOsvaldo BorrelliEleni VolonakiRobert DziubakRosan MeyerMamoun ElawadNeil Sebire Source Type: research

Ultrastructural features of eosinophilic oesophagitis: impact of treatment on desmosomes
Conclusions Consistent with clinical and molecular findings, our ultrastructural data provide support for an altered oesophageal barrier in paediatric cases with active EoE, which may improve following treatment.
Source: Journal of Clinical Pathology - December 16, 2014 Category: Pathology Authors: Capocelli, K. E., Fernando, S. D., Menard-Katcher, C., Furuta, G. T., Masterson, J. C., Wartchow, E. P. Tags: Oesophagus, JCP Education, Immunology (including allergy), Inflammation, Clinical diagnostic tests Original article Source Type: research

Apoptotic enteropathy caused by antimetabolites and TNF-{alpha} antagonists
Conclusions Pathologists should be aware of the expanding spectrum of drugs that can cause apoptotic enteropathy, including antimetabolites and tumour necrosis factor-α inhibitors.
Source: Journal of Clinical Pathology - June 19, 2014 Category: Pathology Authors: Soldini, D., Gaspert, A., Montani, M., Reineke, T., Rogler, G., Odze, R., Weber, A. Tags: Neurogastroenterology, Immunology (including allergy), Clinical diagnostic tests Original article Source Type: research

Chronic low-dose aspirin use does not alter colonic mucosa in asymptomatic individuals: a prospective cross-sectional study (STROBE 1a)
Conclusions We observed no specific MC features in asymptomatic chronic low-dose aspirin users. We found subtle physiological and histopathological differences between the bowel segments.
Source: Journal of Clinical Pathology - January 15, 2014 Category: Pathology Authors: Zagorowicz, E., Mroz, A., Kraszewska, E., Rupinski, M., Kaminski, M. F., Regula, J. Tags: Endoscopy, Immunology (including allergy), Colon cancer, Inflammation, Clinical diagnostic tests Original article Source Type: research

Eosinophilic oesophagitis in children: responders and non-responders to swallowed fluticasone
Conclusions Clinical characteristics of children with EO at baseline were similar in responders and non-responders, but a more severe inflammation in oesophageal mucosa was associated with a higher response rate to fluticasone treatment.
Source: Journal of Clinical Pathology - April 21, 2013 Category: Pathology Authors: Boldorini, R., Mercalli, F., Oderda, G. Tags: Immunology (including allergy), Inflammation Original article Source Type: research