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Specialty: Neurosurgery

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Total 602 results found since Jan 2013.

A service development audit of fampridine use in ms
Conclusions The 2MWT and accelerometry are good objective measures of walking disability in addition to the T25FW. Accelerometry provides additional real–life data regarding activity during the day, and offers information regarding the impact of fatigue on a patient. The MSWS–12 subjectively measures impact of walking disability and the ABC score predicts falls. The use of an assistive device identifies walking disability and predicts risk of falls. Given the uncertainty regarding falls risk in patients using fampridine, physicians should consider using these tools to monitor patients under consideration for the drug.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Hadavi, S., Giovannoni, G., Dobson, R. Tags: Immunology (including allergy), Multiple sclerosis Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Efficacy and safety of natalizumab treatment for relapsing-remitting multiple sclerosis: interim results of the tysabri(r) observational programme in the uk
Conclusions In this interim analysis of UK TOP results, patients treated with natalizumab had significantly improved ARRs, regardless of baseline treatment or relapse history. EDSS scores remained stable over time. Safety data were consistent with natalizumab's known safety profile. Analyses of UK TOP data over longer periods of time will further characterise the effect of natalizumab on disability, as well as on other long–term efficacy and safety parameters in a real–world setting.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Hanna, J., Rosen, J. P., Smethurst, C. Tags: Immunology (including allergy), Infection (neurology), Multiple sclerosis Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Unravelling the mysteries of sporadic cjd
Conclusions While there were differing trends, the lack of distinct clinical or pathological findings by sub–type suggest that these groups do not represent unique strains of prions, but rather groupings over a spectrum of disease.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Mackay, G., Yull, H., Ironside, J., Head, M., Knight, R. Tags: Immunology (including allergy) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Probing the potential for functional recovery in patients with neuromyelitis optica using visuomotor practice
Conclusion Refuting our initial hypothesis, we found that visuomotor improvements in patients were comparable to those of healthy volunteers, suggesting that plasticity is preserved in NMO. Damage to functional "bottlenecks" did not appear to be a factor in preventing visuomotor improvement with practice, suggesting that the limits of adaptive plasticity in NMO may result from a complex interaction between distribution, location and type of damage. The effect of cognitive dysfunction on the ability to improve performance in the more cognitively demanding task condition emphasises the importance of tailoring recovery–...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: John, B. E., Luppe, S., Khirwadkar, H., Smalley, M., Hourihan, M., Robertson, N., Tomassini, V. Tags: Immunology (including allergy), Cranial nerves, Multiple sclerosis, Neuroimaging, Neuromuscular disease, Peripheral nerve disease, Spinal cord, Ophthalmology, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting wit Source Type: research

Does jcv antibody positivity encourage cessation of natalizumab therapy in multiple sclerosis?
Discussion JCv antibody status had little influence on this cohort's decision to discontinue or remain on natalizumab therapy. It is important that patients understand therapeutic benefits and potential risks of alternative treatments before discontinuing due to JCv status alone. Further validation of this risk stratification measure is important.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Lonergan, R., Kinsella, K., Kelly, S., Duggan, M., Scott, J., O'Rourke, K., Lynch, T., Hutchinson, M., Tubridy, N., McGuigan, C. Tags: Immunology (including allergy), Multiple sclerosis, Drugs: musculoskeletal and joint diseases Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Cannabinoid use in progressive inflammatory brain disease (cupid) mri sub-study
Conclusion 9–THC was not better than placebo at reducing the rates of new T1 or T2 lesions or brain atrophy in patients with progressive MS.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Mallik, S., Ball, S., Dalton, C., MacManus, D., Tozer, D., Miller, D., Zajicek, J. Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Multiple sclerosis, Stroke, Radiology, Drugs: musculoskeletal and joint diseases, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Phy Source Type: research

Regional patterns of grey matter atrophy and magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups
Conclusions Assuming that reduced GM MTR implies demyelination and atrophy reflects neuronal loss, the results suggest that: (i) in progressive (SP and PP) MS there is overall more extensive GM demyelination than neuronal loss; (ii) in RRMS there is overall more extensive GM neuronal loss with less noticeable demyelination, (iii) cortical demyelination occurs in more regions in SPMS and PPMS than RRMS; (iv) demyelination and neuronal loss often occur in different locations in the cortex, and (v) co–existent demyelination and neuronal loss is most evident in the thalamus. The variation in regional abnormalities argue ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Mallik, S., Muhlert, N., Samson, R., Wheeler-Kingshott, C., Miller, D., Chard, D. Tags: Immunology (including allergy), Multiple sclerosis Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

The bradykinesia-akinesia incoordination test: a simple objective test in multiple sclerosis
Conclusion The BRAIN test is a widely–available, objective test of upper limb motor function in neurological disease and can be use in the outpatient clinic, home and in clinical trials. Tapping speed is reduced in MS patients when compared to healthy controls and by a similar extent to that seen in PD. MS patients do not have prolonged dwell time when pressing keys, which is a feature of the PD patient group and perhaps extra–pyramidal slowing. This potential for the BRAIN test in differentiating pyramidal from extra–pyramidal motor dysfunction requires further study.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Hadavi, S., Shribman, S., Nagy, A., Acharya, S., Fearnley, J., Dobson, R., Lees, A., Giovannoni, G., Noyce, A. Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Multiple sclerosis, Parkinson's disease Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Multiple sclerosis and the iranian revolution
Multiple Sclerosis (MS) is a complex neurological disorder most likely caused by gene–environment interactions. There is a latitudinal gradient of MS prevalence and vitamin D deficiency has been strongly implicated in MS aetiology. Iran is a country of high levels of sunshine which has previously been considered a low–risk MS region. However, Iran has recently observed an 8.3–fold rise in the incidence of MS between 1989–2006.1 Previous studies have indicated a genetic predisposition to MS in the Iranian population but genetic changes are unlikely to account for the substantial rise in MS over the l...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Pakpoor, J., Ramagopalan, S. Tags: Immunology (including allergy), Multiple sclerosis Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Improving the model for the uk ms disease modifying treatment risk sharing scheme analysis: a new natural history dataset
Conclusion The use of the BCMS dataset as a ‘natural history’ comparator cohort has allowed us to develop a more reliable model, to analyse the cost effectiveness of the DMTs in the UK risk sharing scheme. This BCMS dataset and model will be used in the price adjustment analysis for the 4 and 6 year results. We gratefully acknowledge the BC MS Clinic neurologists who contributed to the BCC data base, and to the UK neurologists, nurses and administrational staff who have been key in collecting the RSS data.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Palace, J., Bregenzer, T., Tremlett, H., Duddy, M., Boggild, M., Zhu, F., Oger, J., Dobson, C. Tags: Immunology (including allergy) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Progressive neurological deficit from a solitary spatially isolated demyelinating lesion: solitary sclerosis-the first series from the uk
Conclusion Solitary demyelinating lesions can produce progressive myelopathy like primary progressive Multiple Sclerosis. Though histology is as yet unavailable, it is more than likely to be demyelinating in nature. Thus solitary sclerosis should be in the differential diagnosis of progressive myelopathy and invasive diagnostic tests (like spinal cord biopsy) for suspected tumours/ granulomatous disorders must be carefully reconsidered in light of this additional possibility.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Rathnasabapathi, D., Elsone, L., Jacob, A. Tags: Immunology (including allergy), Cranial nerves, Multiple sclerosis, Spinal cord, Ophthalmology, Radiology, Surgical diagnostic tests, Surgical oncology Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), L Source Type: research

Lobar distribution of cortical grey matter lesions in multiple sclerosis clinical subgroups
Conclusions Using PSIR at 3T, lesions involving CGM were visible in all lobes. A higher number of CGM lesions were noted in the frontal and temporal lobes both relapsing remitting and progressive MS subgroups. Occipital CGM lesions were uncommon.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Sethi, V., Yousry, T. A., Muhlert, N., Tozer, D., Ron, M., Golay, X., Wheeler-Kingshott, C., Miller, D. H., Chard, D. T. Tags: Immunology (including allergy), Multiple sclerosis, Memory disorders (psychiatry) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

A case of neuromyelitis optica with locked-in syndrome
We report a case of a 40 years old male who presented with ascending weakness and sphincter involvement. While in hospital, he became quadriplegic and developed bifacial weakness and frozen eyes. He was fully conscious and was obeying commands by blinking. MR scan showed diffuse hyperintense T2 signal change from the mid brain up to the conus medullaris. Lumbar puncture showed pleocytosis with low glucose ratio. Oligoclonal bands were absent. Infectious screen was negative. Serum aquaporin 4 antibodies were positive. Patient showed a significant response to a course of plasma exchange and steroids. He was subsequently star...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Sharaf, N., Gosal, D. Tags: Immunology (including allergy), Cranial nerves, Multiple sclerosis, Ophthalmology Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Baseline responses of multiple sclerosis patients participating in the proms survey: impact of disease-modifying therapies and support services on patient-reported outcomes
The PROMs (Patient–Reported Outcome Measures) Survey is an ongoing, observational, prospective, cohort survey of UK patients newly diagnosed with relapsing Multiple Sclerosis (MS) receiving an injectable disease–modifying drug (DMD) (subcutaneous [sc] interferon [IFN] beta–1a or ‘other DMD’). The survey was designed to establish the impact of DMDs and associated support services on patient–reported experience measures and outcomes in MS, in response to proposed National Health Service (NHS) reforms for the reimbursement of DMDs for MS. Independent homecare companies responsible for deliv...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Shields, S., Parkes, L. Tags: Immunology (including allergy), Multiple sclerosis, Pain (neurology) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Most neurologists in scotland do not use the mcdonald 2010 criteria to diagnose multiple sclerosis
Conclusion Our data indicate significant variation in practice amongst Scottish neurologists regarding the diagnosis of MS. It seems that few are enthusiastic about applying the current diagnostic criteria after a single attack (CIS), even if the diagnostic criteria are met. Case mix, clinical expertise and experience may explain some of this variation, and given the lack of evidence for aggressive treatment of CIS, such diagnostic caution is perhaps justified. It would be of interest to repeat the audit UK wide, and internationally, and our prediction would be that some countries may embrace the criteria with more enthusi...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Lumley, R., Davenport, R., Williams, A. Tags: Immunology (including allergy), Multiple sclerosis, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research