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The therapeutic landscape of HIV-1 via genome editing.
Abstract Current treatment for HIV-1 largely relies on chemotherapy through the administration of antiretroviral drugs. While the search for anti-HIV-1 vaccine remain elusive, the use of highly active antiretroviral therapies (HAART) have been far-reaching and has changed HIV-1 into a manageable chronic infection. There is compelling evidence, including several side-effects of ARTs, suggesting that eradication of HIV-1 cannot depend solely on antiretrovirals. Gene therapy, an expanding treatment strategy, using RNA interference (RNAi) and programmable nucleases such as meganuclease, zinc finger nuclease (ZFN), tra...
Source: AIDS Research and Therapy - July 14, 2017 Category: Infectious Diseases Authors: Kwarteng A, Ahuno ST, Kwakye-Nuako G Tags: AIDS Res Ther Source Type: research