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Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway.
CONCLUSIONS: This study revealed the AKT/PTEN/FOXO4 pathway as a potential candidate of target for treatment of p53-null liver cancers. PMID: 28769986 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - August 6, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

SOD2 Mediates Curcumin-Induced Protection against Oxygen-Glucose Deprivation/Reoxygenation Injury in HT22 Cells.
Authors: Wang Y, Zhang Y, Yang L, Yuan J, Jia J, Yang S Abstract Curcumin (Cur) induces neuroprotection against brain ischemic injury; however, the mechanism is still obscure. The aim of this study is to explore the potential neuroprotective mechanism of curcumin against oxygen-glucose deprivation/reoxygenation (OGD/R) injury in HT22 cells and investigate whether type-2 superoxide dismutase (SOD2) is involved in the curcumin-induced protection. In the present study, HT22 neuronal cells were treated with 3 h OGD plus 24 h reoxygenation to mimic ischemia/reperfusion injury. Compared with the normal cultured contr...
Source: Evidence-based Complementary and Alternative Medicine - November 1, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Curcumin Alleviates D-Galactose-Induced Cardiomyocyte Senescence by Promoting Autophagy via the SIRT1/AMPK/mTOR Pathway
Evid Based Complement Alternat Med. 2022 Jul 16;2022:2990843. doi: 10.1155/2022/2990843. eCollection 2022.ABSTRACTOxidative stress and impaired autophagy are the hallmarks of cardiac aging. However, there are no specific drugs available to prevent cardiac aging. Curcumin is a natural polyphenolic drug with antioxidant, antiaging, and autophagy-promoting effects. Here, we describe the preventive role of Curcumin in cardiac aging through the induction of autophagy and the restoration of autophagy via the SIRT1/AMPK/mTOR pathway. The number of cells positive for senescence-associated β-galactosidase, P53, P16, and intracellu...
Source: Evidence-based Complementary and Alternative Medicine - July 26, 2022 Category: Complementary Medicine Authors: Lei Yang Jun Shi Xiaowan Wang Rong Zhang Source Type: research