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Molecules, Vol. 23, Pages 2755: HSP70 Acetylation Prevents Combined mTORC1/2 Inhibitor and Curcumin Treatment-Induced Apoptosis
Kyu Kwon We previously reported that PP242 (dual inhibitor of mTORC1/2) plus curcumin induced apoptotic cell death through lysosomal membrane permeabilization (LMP)-mediated autophagy. However, the relationship between ER stress and apoptotic cell death by combined PP242 and curcumin treatment remains unknown. In the present study, we found that combined PP242 and curcumin treatment induced cytosolic Ca2+ release and ER stress. Interestingly, pretreatment with the chemical chaperones (TUDCA and 4-PBA) and knockdown of CHOP and ATF4 by siRNA did not abolish combined treatment-induced apoptosis in renal carcinoma cells....
Source: Molecules - October 24, 2018 Category: Chemistry Authors: Seung Un Seo Kyoung-jin Min Seon Min Woo Ji Hae Seo Taeg Kyu Kwon Tags: Article Source Type: research

Molecules, Vol. 26, Pages 2382: Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies
arrabi Kwang Seok Ahn The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment of cancer patients, it is of great importance to reveal the molecular pathways and mechanisms involved in chemoresistance. Cisplatin (CP) is a platinum-containing drug with anti-tumor activity against different cancers in both pre-clinical and clinical studies. However, drug resistance has restricted its potential in the treatment of cancer patients. CP can promote levels of free radicals, particularly reactive oxygen species (ROS) to induce cell death. Due to the double-edged sword role of ROS ...
Source: Molecules - April 19, 2021 Category: Chemistry Authors: Sepideh Mirzaei Kiavash Hushmandi Amirhossein Zabolian Hossein Saleki Seyed Mohammad Reza Torabi Adnan Ranjbar SeyedHesam SeyedSaleh Seyed Omid Sharifzadeh Haroon Khan Milad Ashrafizadeh Ali Zarrabi Kwang Seok Ahn Tags: Review Source Type: research

Molecules, Vol. 27, Pages 1346: Mitochondrial ROS-Mediated Metabolic and Cytotoxic Effects of Isoproterenol on Cardiomyocytes Are p53-Dependent and Reversed by Curcumin
g-Han Lee Acute β-adrenergic stimulation contributes to heart failure. Here, we investigated the role of p53 in isoproterenol (ISO)-mediated metabolic and oxidative stress effects on cardiomyocytes and explored the direct protective effects offered by the antioxidant nutraceutical curcumin. Differentiated H9C2 rat cardiomyocytes treated with ISO were assayed for glucose uptake, lactate release, and mitochondrial reactive oxygen species (ROS) generation. Survival was assessed by sulforhodamine B assays. Cardiomyocytes showed significantly decreased glucose uptake and lactate release, as well as increased ce...
Source: Molecules - February 16, 2022 Category: Chemistry Authors: Jin Hee Lee Da Hae Kim MinA Kim Kyung-Ho Jung Kyung-Han Lee Tags: Article Source Type: research