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Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research
Conclusions
Our proposed new research paradigm, adapted from 21st-century toxicology, would involve the following aspects:
Developing a big picture of human diseases, integrating extrinsic and intrinsic causes, and linking environmental sciences with medical research using systems biology.
Introducing a disease AOP concept, analogous to toxicity AOPs, with the intention of providing a unified framework for describing relevant pathophysiology pathways and networks across multiple biological levels.
Creating a strong focus on advanced human-specific research (in vitro, ex vivo, in vivo, and in silico) in place of empirical,...
Source: EHP Research - November 2, 2015 Category: Environmental Health Authors: Web Admin Tags: Brief Communication November 2015 Source Type: research
