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Infectious Disease: Rabies
Therapy: Gene Therapy
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Total 2 results found since Jan 2013.
Optical Imaging and Gene Therapy with Neuroblastoma‐Targeting Polymeric Nanoparticles for Potential Theranostic Applications
Recently, targeted delivery systems based on functionalized polymeric nanoparticles have attracted a great deal of attention in cancer diagnosis and therapy. Specifically, as neuroblastoma occurs in infancy and childhood, targeted delivery may be critical to reduce the side effects that can occur with conventional approaches, as well as to achieve precise diagnosis and efficient therapy. Thus, biocompatible poly(d,l‐lactide‐co‐glycolide) (PLG) nanoparticles containing an imaging probe and therapeutic gene are prepared, followed by modification with rabies virus glycoprotein (RVG) peptide for neuroblastoma‐targeting...
Source: Small - November 17, 2015 Category: Nanotechnology Authors: Jangwook Lee, Eun Ju Jeong, Yeon Kyung Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee Tags: Full Paper Source Type: research
Theranostics: Optical Imaging and Gene Therapy with Neuroblastoma‐Targeting Polymeric Nanoparticles for Potential Theranostic Applications (Small 9/2016)
Ligand‐modified, gene‐loaded nanoparticles (NPs) are designed and prepared as a tumor‐targeting theranostic agent by I. C. Kwon, K. Y. Lee, and co‐workers. The nanoparticles offer neuroblastoma‐specific in‐vivo optical imaging, and adding a therapeutic gene cocktail into the NPs could play a critical role for gene‐therapy‐based on RNAi. On page 1201, dye‐labeled NPs are modified with rabies virus glycoprotein peptide to enhance the receptor‐mediated uptake by neuroblastoma, and an siRNA cocktail is loaded into the NPs, inducing RNA interference and significantly suppressing tumor growth in a mouse model.
Source: Small - March 1, 2016 Category: Nanotechnology Authors: Jangwook Lee, Eun Ju Jeong, Yeon Kyung Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee Tags: Inside Front Cover Source Type: research
