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Allergy to Omalizumab: Lessons from a Reaction to the Coronavirus 2019 Vaccine
Intern Med. 2023 Feb 1. doi: 10.2169/internalmedicine.1169-22. Online ahead of print.ABSTRACTOmalizumab can cause hypersensitivity reactions. We herein report the first case of an 18-year-old woman with refractory cough-predominant asthma that correlated with allergic reactions caused by omalizumab and the coronavirus disease 2019 (COVID-19) vaccine. The patient developed angioedema after taking omalizumab. She had previously experienced intense coughing immediately after receiving a COVID-19 vaccine. A skin prick test was positive for polysorbate 20, which was probably the cause of the allergic reactions to omalizumab and...
Source: Internal Medicine - February 1, 2023 Category: Internal Medicine Authors: Takeshi Matsumoto Yumiko Sakurai Takahiro Fujiki Yusuke Kusakabe Emi Nakayama Ayaka Tanaka Naoki Yamamoto Kensaku Aihara Shinpachi Yamaoka Michiaki Mishima Source Type: research

Effect of Timing of and Adherence to Social Distancing Measures on COVID-19 Burden in the United States : A Simulation Modeling Approach.
CONCLUSION: The timing of implementing and easing social distancing measures has major effects on the number of COVID-19 cases. PRIMARY FUNDING SOURCE: National Institute of Allergy and Infectious Diseases. PMID: 33105091 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - October 27, 2020 Category: Internal Medicine Authors: Alagoz O, Sethi AK, Patterson BW, Churpek M, Safdar N Tags: Ann Intern Med Source Type: research

Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure.
CONCLUSION: Care must be taken in interpreting RT-PCR tests for SARS-CoV-2 infection-particularly early in the course of infection-when using these results as a basis for removing precautions intended to prevent onward transmission. If clinical suspicion is high, infection should not be ruled out on the basis of RT-PCR alone, and the clinical and epidemiologic situation should be carefully considered. PRIMARY FUNDING SOURCE: National Institute of Allergy and Infectious Diseases, Johns Hopkins Health System, and U.S. Centers for Disease Control and Prevention. PMID: 32422057 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - May 12, 2020 Category: Internal Medicine Authors: Kucirka LM, Lauer SA, Laeyendecker O, Boon D, Lessler J Tags: Ann Intern Med Source Type: research

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application.
Conclusion: This work provides additional evidence for a median incubation period for COVID-19 of approximately 5 days, similar to SARS. Our results support current proposals for the length of quarantine or active monitoring of persons potentially exposed to SARS-CoV-2, although longer monitoring periods might be justified in extreme cases. Primary Funding Source: U.S. Centers for Disease Control and Prevention, National Institute of Allergy and Infectious Diseases, National Institute of General Medical Sciences, and Alexander von Humboldt Foundation. PMID: 32150748 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - March 9, 2020 Category: Internal Medicine Authors: Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, Azman AS, Reich NG, Lessler J Tags: Ann Intern Med Source Type: research