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Infectious Disease: Coronavirus
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Interpretation of Hematological, Biochemical, and Immunological Findings of COVID-19 Disease: Biomarkers Associated with Severity and Mortality
This study aimed at examining several laboratory factors, especially inflammatory and immunological mediators, to identify severity and mortality associated biomarkers. Ninety-three hospitalized patients with confirmed coronavirus disease 2019 (COVID-19) were classified based on disease severity. The levels of biochemical, hematological, immunological, and inflammatory mediators were assessed, and their association with severity and mortality were evaluated. Hospitalized patients were mostly men (77.4%) with an average (standard deviation) age of 59.14 (14.81) years. The mortality rate was significantly higher in critical ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Tooba Ghazanfari Mohammad Reza Salehi Saeed Namaki Jalil Arabkheradmand Abdolrahman Rostamian Maryam Rajabnia Chenary Sara Ghaffarpour Sussan Kaboudanian Ardestani Maryam Edalatifard Mohammad Mehdi Naghizadeh Saeed Mohammadi Maryam Mahloujirad Alireza Iza Source Type: research
Mechanisms of COVID-19 Entry into the Cell: Potential Therapeutic Approaches Based on Virus Entry Inhibition in COVID-19 Patients with Underlying Diseases
This study investigated virus entry mechanisms through membrane receptors, their role in the pathogenesis of COVID-19 and underlying diseases, and treatment methods based on the viral entrance inhibition. According to existing studies, inhibition of ACE2 can increase oxidative stress, inflammation, fibrosis and ultimately exacerbate underlying diseases such as cardiovascular disease, kidney disease, diabetes, and hypertension in individuals with COVID-19. The ACE2 inhibition is not suitable for patients with COVID-19 with underlying diseases, but it seems that the recombinant ACE2 solution is more appropriate for inhibitin...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Hadis Musavi Omid Abazari Mohamad Sadegh Safaee Atena Variji Bahare Koohshekan Fatemeh Kalaki-Jouybari Zeinab Barartabar Pejman Hakemi Soleiman Mahjoub Source Type: research
Relationship between Bacillus Calmette Guerin Vaccination Policy and Coronavirus Disease-2019 (COVID-19) Incidence
Iran J Allergy Asthma Immunol. 2021 Feb 11;20(1):106-113. doi: 10.18502/ijaai.v20i1.5417.ABSTRACTBacillus Calmette Guerin (BCG) was designed for protecting children against tuberculosis. Also, it can protect against other infectious diseases through the induction of trained immunity. Due to its heterologous protective effects, the BCG vaccine has been proposed as atreatment option for coronavirus disease-2019 (COVID-19). Epidemiological studies have found that countries without BCG vaccination policy have experienced higher mortality rates related toCOVID-19 infection than those with BCG vaccination policy. However, there ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Soheila Alyasin Zahra Kanannejad Hossein Esmaeilzadeh Hesamedin Nabavizadeh Mohammad Amin Ghatee Reza Amin Source Type: research
Interpretation of Hematological, Biochemical, and Immunological Findings of COVID-19 Disease: Biomarkers Associated with Severity and Mortality
This study aimed at examining several laboratory factors, especially inflammatory and immunological mediators, to identify severity and mortality associated biomarkers. Ninety-three hospitalized patients with confirmed coronavirus disease 2019 (COVID-19) were classified based on disease severity. The levels of biochemical, hematological, immunological, and inflammatory mediators were assessed, and their association with severity and mortality were evaluated. Hospitalized patients were mostly men (77.4%) with an average (standard deviation) age of 59.14 (14.81) years. The mortality rate was significantly higher in critical ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Tooba Ghazanfari Mohammad Reza Salehi Saeed Namaki Jalil Arabkheradmand Abdolrahman Rostamian Maryam Rajabnia Chenary Sara Ghaffarpour Sussan Kaboudanian Ardestani Maryam Edalatifard Mohammad Mehdi Naghizadeh Saeed Mohammadi Maryam Mahloujirad Alireza Iza Source Type: research
Mechanisms of COVID-19 Entry into the Cell: Potential Therapeutic Approaches Based on Virus Entry Inhibition in COVID-19 Patients with Underlying Diseases
This study investigated virus entry mechanisms through membrane receptors, their role in the pathogenesis of COVID-19 and underlying diseases, and treatment methods based on the viral entrance inhibition. According to existing studies, inhibition of ACE2 can increase oxidative stress, inflammation, fibrosis and ultimately exacerbate underlying diseases such as cardiovascular disease, kidney disease, diabetes, and hypertension in individuals with COVID-19. The ACE2 inhibition is not suitable for patients with COVID-19 with underlying diseases, but it seems that the recombinant ACE2 solution is more appropriate for inhibitin...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Hadis Musavi Omid Abazari Mohamad Sadegh Safaee Atena Variji Bahare Koohshekan Fatemeh Kalaki-Jouybari Zeinab Barartabar Pejman Hakemi Soleiman Mahjoub Source Type: research
Relationship between Bacillus Calmette Guerin Vaccination Policy and Coronavirus Disease-2019 (COVID-19) Incidence
Iran J Allergy Asthma Immunol. 2021 Feb 11;20(1):106-113. doi: 10.18502/ijaai.v20i1.5417.ABSTRACTBacillus Calmette Guerin (BCG) was designed for protecting children against tuberculosis. Also, it can protect against other infectious diseases through the induction of trained immunity. Due to its heterologous protective effects, the BCG vaccine has been proposed as atreatment option for coronavirus disease-2019 (COVID-19). Epidemiological studies have found that countries without BCG vaccination policy have experienced higher mortality rates related toCOVID-19 infection than those with BCG vaccination policy. However, there ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Soheila Alyasin Zahra Kanannejad Hossein Esmaeilzadeh Hesamedin Nabavizadeh Mohammad Amin Ghatee Reza Amin Source Type: research
Interpretation of Hematological, Biochemical, and Immunological Findings of COVID-19 Disease: Biomarkers Associated with Severity and Mortality
This study aimed at examining several laboratory factors, especially inflammatory and immunological mediators, to identify severity and mortality associated biomarkers. Ninety-three hospitalized patients with confirmed coronavirus disease 2019 (COVID-19) were classified based on disease severity. The levels of biochemical, hematological, immunological, and inflammatory mediators were assessed, and their association with severity and mortality were evaluated. Hospitalized patients were mostly men (77.4%) with an average (standard deviation) age of 59.14 (14.81) years. The mortality rate was significantly higher in critical ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Tooba Ghazanfari Mohammad Reza Salehi Saeed Namaki Jalil Arabkheradmand Abdolrahman Rostamian Maryam Rajabnia Chenary Sara Ghaffarpour Sussan Kaboudanian Ardestani Maryam Edalatifard Mohammad Mehdi Naghizadeh Saeed Mohammadi Maryam Mahloujirad Alireza Iza Source Type: research
Mechanisms of COVID-19 Entry into the Cell: Potential Therapeutic Approaches Based on Virus Entry Inhibition in COVID-19 Patients with Underlying Diseases
This study investigated virus entry mechanisms through membrane receptors, their role in the pathogenesis of COVID-19 and underlying diseases, and treatment methods based on the viral entrance inhibition. According to existing studies, inhibition of ACE2 can increase oxidative stress, inflammation, fibrosis and ultimately exacerbate underlying diseases such as cardiovascular disease, kidney disease, diabetes, and hypertension in individuals with COVID-19. The ACE2 inhibition is not suitable for patients with COVID-19 with underlying diseases, but it seems that the recombinant ACE2 solution is more appropriate for inhibitin...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Hadis Musavi Omid Abazari Mohamad Sadegh Safaee Atena Variji Bahare Koohshekan Fatemeh Kalaki-Jouybari Zeinab Barartabar Pejman Hakemi Soleiman Mahjoub Source Type: research
Relationship between Bacillus Calmette Guerin Vaccination Policy and Coronavirus Disease-2019 (COVID-19) Incidence
Iran J Allergy Asthma Immunol. 2021 Feb 11;20(1):106-113. doi: 10.18502/ijaai.v20i1.5417.ABSTRACTBacillus Calmette Guerin (BCG) was designed for protecting children against tuberculosis. Also, it can protect against other infectious diseases through the induction of trained immunity. Due to its heterologous protective effects, the BCG vaccine has been proposed as atreatment option for coronavirus disease-2019 (COVID-19). Epidemiological studies have found that countries without BCG vaccination policy have experienced higher mortality rates related toCOVID-19 infection than those with BCG vaccination policy. However, there ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Soheila Alyasin Zahra Kanannejad Hossein Esmaeilzadeh Hesamedin Nabavizadeh Mohammad Amin Ghatee Reza Amin Source Type: research
Interpretation of Hematological, Biochemical, and Immunological Findings of COVID-19 Disease: Biomarkers Associated with Severity and Mortality
This study aimed at examining several laboratory factors, especially inflammatory and immunological mediators, to identify severity and mortality associated biomarkers. Ninety-three hospitalized patients with confirmed coronavirus disease 2019 (COVID-19) were classified based on disease severity. The levels of biochemical, hematological, immunological, and inflammatory mediators were assessed, and their association with severity and mortality were evaluated. Hospitalized patients were mostly men (77.4%) with an average (standard deviation) age of 59.14 (14.81) years. The mortality rate was significantly higher in critical ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Tooba Ghazanfari Mohammad Reza Salehi Saeed Namaki Jalil Arabkheradmand Abdolrahman Rostamian Maryam Rajabnia Chenary Sara Ghaffarpour Sussan Kaboudanian Ardestani Maryam Edalatifard Mohammad Mehdi Naghizadeh Saeed Mohammadi Maryam Mahloujirad Alireza Iza Source Type: research
Mechanisms of COVID-19 Entry into the Cell: Potential Therapeutic Approaches Based on Virus Entry Inhibition in COVID-19 Patients with Underlying Diseases
This study investigated virus entry mechanisms through membrane receptors, their role in the pathogenesis of COVID-19 and underlying diseases, and treatment methods based on the viral entrance inhibition. According to existing studies, inhibition of ACE2 can increase oxidative stress, inflammation, fibrosis and ultimately exacerbate underlying diseases such as cardiovascular disease, kidney disease, diabetes, and hypertension in individuals with COVID-19. The ACE2 inhibition is not suitable for patients with COVID-19 with underlying diseases, but it seems that the recombinant ACE2 solution is more appropriate for inhibitin...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Hadis Musavi Omid Abazari Mohamad Sadegh Safaee Atena Variji Bahare Koohshekan Fatemeh Kalaki-Jouybari Zeinab Barartabar Pejman Hakemi Soleiman Mahjoub Source Type: research
Relationship between Bacillus Calmette Guerin Vaccination Policy and Coronavirus Disease-2019 (COVID-19) Incidence
Iran J Allergy Asthma Immunol. 2021 Feb 11;20(1):106-113. doi: 10.18502/ijaai.v20i1.5417.ABSTRACTBacillus Calmette Guerin (BCG) was designed for protecting children against tuberculosis. Also, it can protect against other infectious diseases through the induction of trained immunity. Due to its heterologous protective effects, the BCG vaccine has been proposed as atreatment option for coronavirus disease-2019 (COVID-19). Epidemiological studies have found that countries without BCG vaccination policy have experienced higher mortality rates related toCOVID-19 infection than those with BCG vaccination policy. However, there ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Soheila Alyasin Zahra Kanannejad Hossein Esmaeilzadeh Hesamedin Nabavizadeh Mohammad Amin Ghatee Reza Amin Source Type: research
Interpretation of Hematological, Biochemical, and Immunological Findings of COVID-19 Disease: Biomarkers Associated with Severity and Mortality
This study aimed at examining several laboratory factors, especially inflammatory and immunological mediators, to identify severity and mortality associated biomarkers. Ninety-three hospitalized patients with confirmed coronavirus disease 2019 (COVID-19) were classified based on disease severity. The levels of biochemical, hematological, immunological, and inflammatory mediators were assessed, and their association with severity and mortality were evaluated. Hospitalized patients were mostly men (77.4%) with an average (standard deviation) age of 59.14 (14.81) years. The mortality rate was significantly higher in critical ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Tooba Ghazanfari Mohammad Reza Salehi Saeed Namaki Jalil Arabkheradmand Abdolrahman Rostamian Maryam Rajabnia Chenary Sara Ghaffarpour Sussan Kaboudanian Ardestani Maryam Edalatifard Mohammad Mehdi Naghizadeh Saeed Mohammadi Maryam Mahloujirad Alireza Iza Source Type: research
Mechanisms of COVID-19 Entry into the Cell: Potential Therapeutic Approaches Based on Virus Entry Inhibition in COVID-19 Patients with Underlying Diseases
This study investigated virus entry mechanisms through membrane receptors, their role in the pathogenesis of COVID-19 and underlying diseases, and treatment methods based on the viral entrance inhibition. According to existing studies, inhibition of ACE2 can increase oxidative stress, inflammation, fibrosis and ultimately exacerbate underlying diseases such as cardiovascular disease, kidney disease, diabetes, and hypertension in individuals with COVID-19. The ACE2 inhibition is not suitable for patients with COVID-19 with underlying diseases, but it seems that the recombinant ACE2 solution is more appropriate for inhibitin...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Hadis Musavi Omid Abazari Mohamad Sadegh Safaee Atena Variji Bahare Koohshekan Fatemeh Kalaki-Jouybari Zeinab Barartabar Pejman Hakemi Soleiman Mahjoub Source Type: research
Relationship between Bacillus Calmette Guerin Vaccination Policy and Coronavirus Disease-2019 (COVID-19) Incidence
Iran J Allergy Asthma Immunol. 2021 Feb 11;20(1):106-113. doi: 10.18502/ijaai.v20i1.5417.ABSTRACTBacillus Calmette Guerin (BCG) was designed for protecting children against tuberculosis. Also, it can protect against other infectious diseases through the induction of trained immunity. Due to its heterologous protective effects, the BCG vaccine has been proposed as atreatment option for coronavirus disease-2019 (COVID-19). Epidemiological studies have found that countries without BCG vaccination policy have experienced higher mortality rates related toCOVID-19 infection than those with BCG vaccination policy. However, there ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Soheila Alyasin Zahra Kanannejad Hossein Esmaeilzadeh Hesamedin Nabavizadeh Mohammad Amin Ghatee Reza Amin Source Type: research
