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Dupilumab improves all ACQ-5 individual items in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) and asthma: results from a phase 2a trial
Conclusion: In CRSwNP pts with asthma, DPL significantly improved all asthma-related items. Improvement correlated with reduced nasal polyp burden.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Hellings, P., Bachert, C., Mullol, J., Hamilos, D., Naclerio, R., Joish, V., Mannent, L., Amin, N., Abbe, A., Taniou, C., Pirozzi, G., Graham, N., Khan, A. Tags: Allergy and immunology Source Type: research

All that wheezes is not asthma: adult tracheomalacia resulting from innominate artery compression
An 83-year-old woman with no known systemic disease presented to the emergency department with shortness of breath and audible abnormal breath sounds which she had had for 1 week. She reported that the abnormal breath sounds had been heard intermittently for more than a decade, occurring mostly during forceful expiration, coughing or when she had a common cold. One hour later, respiratory distress with accessory muscle use and paradoxical abdominal movement developed, and she was admitted to the intensive care unit for management of impending respiratory failure. The presumed diagnosis was severe asthma due to bilater...
Source: Postgraduate Medical Journal - December 13, 2016 Category: Journals (General) Authors: Keng, L.-T., Chang, C.-J. Tags: Emergency medicine, Journalology, Immunology (including allergy), Asthma, Surgical diagnostic tests, Cardiothoracic surgery, General surgery, Ethics Images in medicine Source Type: research

What is the Mortality Rate for Legionellosis in the Pediatric Population?
Discussion Legionella is often a severe, atypical pneumonia caused by the Legionella pneumophilia. It is a gram-negative bacterium that naturally occurs in water and is transmitted by droplet inhalation. No person-to-person contact has been documented to date. Contaminated water supplies have been documented in cooling tanks, decorative fountains, hot tubs, and large plumbing systems. Household and car air conditioners do not transmit the organism. Risk factors in the pediatric populations for legionellosis are being immunodeficient and exposure. Neonates are at risk from hospital settings. Clinically legionellosis includ...
Source: PediatricEducation.org - September 28, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news