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Infectious Disease: Gastroenteritis
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Total 621 results found since Jan 2013.
Immunogenic Potency of a Chimeric Protein Comprising InvH and IpaD against Salmonella and Shigella spp
Iran J Allergy Asthma Immunol. 2021 Aug 7;20(4):484-493.ABSTRACTShigella and Salmonella cause serious problems in many subjects, including young children and the elderly, especially in developing countries. Chimeric proteins carrying immunogens increase immune response. In-silico tools are applied to design vaccine candidates. Invasion plasmid antigens D (ipaD) gene is one of the Shigella virulence factors. The N-terminal region of the IpaD plays a significant role in invading the host cell. Invasion protein H (invH) gene plays important role in bacterial adherence and entry into epithelial cells. A recombinant chimeric co...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 22, 2021 Category: Allergy & Immunology Authors: Fahimeh Sadat Emami Mahmoudabadi Atina Vakili Shahram Nazarian Jafar Amani Seyed Latif Mousavi Gargari Source Type: research
Wharton's Jelly Mesenchymal Stem Cells-derived Exosomes and Imipenem in Combination Reduce Apoptosis and Inflammatory Responses in E.coli-infected HepG2 Cells
In this study, we investigated the immunomodulatory effect of Wharton's jelly MSC-derived exosomes in combination with imipenem on HepG2 cells infected with Escherichia col i.MSC-derived exosomes were separated from MSCs, which were isolated by flow cytometry. Scanning electron microscopy and dynamic light scanning were used to confirm the presence of exosomes. Quantitative real-time PCR, ELISA, and nitric oxide assay were used to assess the inflammatory response in the infected cells. Annexin-PI was used to measure the extent of apoptosis. The results showed that the combination of imipenem and MSC-derived exosomes were m...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Ali Hazrati Sara Soudi Seyed Mahmoud Hashemi Source Type: research
