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Detection of Novel Autoantibodies to Nucleolin's RNA-binding Domains as a Serum Tumor Biomarker Through ELISA
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):616-625. doi: 10.18502/ijaai.v21i6.11520.ABSTRACTExpression and location of nucleolin are often abnormal in malignancies, which may result in the production of autoantibodies. Despite this, the identification of such autoantibodies may be essential for the early diagnosis and prognosis of cancers. In this investigation, the recombinant nucleolin protein was generated using an Escherichia coli expression system and was used an indirect enzyme-linked immunosorbent assay to detect anti-nucleolin autoantibodies in cancer patients' sera. Lung cancer patients' autoantibodies displ...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Fatemeh Ezzatifar Alireza Rafiei Reza Valadan Hossein Asgarian-Omran Mahmood Jeddi-Tehrani Source Type: research
