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Targeting host calpain proteases decreases influenza A virus infection.
Abstract Influenza A viruses (IAV) trigger contagious acute respiratory diseases. A better understanding of the molecular mechanisms of IAV pathogenesis and host immune responses is required for the development of more efficient treatments of severe influenza. Calpains are intracellular proteases that participate to diverse cellular responses, including inflammation. Here, we used in vitro and in vivo approaches to investigate the role of calpains signalling in IAV pathogenesis. Calpain expression and activity were found altered in IAV-infected bronchial epithelial cells. Using siRNA gene silencing, specific synth...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - January 8, 2016 Category: Cytology Authors: Blanc F, Furio L, Moisy D, Yen HL, Chignard M, Letavernier E, Naffakh N, Mok CK, Si-Tahar M Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research