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A Bivalent Conjugate Vaccine for Malaria and Typhoid Prophylaxis
Malaria is the single leading cause of mortality, especially among children in the developing world. Typhoid fever, caused by infection withSalmonella typhi, is known to be endemic with malaria and causes its own significant disease burden. Scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have developed a novel bivalent vaccine candidate that may effectively prevent malaria and typhoid. This approach significantly enhances immune response to the Pfs25 Malaria transmission blocking antigen and produces a robust immune response againstSalmonella typhi...
Source: NIH OTT Licensing Opportunities - March 1, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research

Enteric fever in a British soldier from Sierra Leone
We report the case of a soldier who developed typhoid despite appropriate vaccination and field hygiene measures, which began 23 days after returning from a deployment in Sierra Leone. The incubation period was longer than average, symptoms started 2 days after stopping doxycycline for malaria chemoprophylaxis and initial blood cultures were negative. The Salmonella enterica serovar Typhi eventually isolated was resistant to amoxicillin, co-amoxiclav, co-trimoxazole and nalidixic acid and had reduced susceptibility to ciprofloxacin. He was successfully treated with ceftriaxone followed by azithromycin, but 1 ...
Source: Journal of the Royal Army Medical Corps - May 25, 2016 Category: Journals (General) Authors: Osborne, L. G., Brown, M., Bailey, M. S. Tags: Infectious diseases, Epidemiologic studies, Immunology (including allergy) Case report Source Type: research