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Steroid induced secondary immune deficiency
Ann Allergy Asthma Immunol. 2023 Jan 18:S1081-1206(23)00011-X. doi: 10.1016/j.anai.2023.01.010. Online ahead of print.ABSTRACTDespite their widespread clinical use, oral corticosteroids (OCSs) are well known to be associated with a myriad of adverse effects, including immunosuppression. By inhibiting transcription factors and affecting leukocyte function, prolonged OCS use leads to significant CD4 lymphopenia, and also often leads to a decrease in serum IgG. Conversely, OCS use has minimal impact on circulating B cell, serum IgM, or serum IgA levels. Although there is a paucity of literature, individuals treated with prolo...
Source: Annals of Allergy, Asthma and Immunology - January 21, 2023 Category: Allergy & Immunology Authors: S Shahzad Mustafa Source Type: research