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Source: Nagoya Journal of Medical Science
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＜Editors' Choice＞ Long-term outcomes of lateral skull base reconstruction with a free omental flap and facial nerve reconstruction
This study is a technical note and a retrospective review. It was conducted in Nagoya University Hospital. Overall, 16 patients (12 women and 4 men; mean age: 55.1 years) underwent lateral skull base reconstruction with a free omental flap after subtotal temporal bone resection or lateral temporal bone resection during 2005-2017. The main outcome measures were postoperative complications and facial nerve recovery: Yanagihara score and House-Brackmann grading system. Complications included partial necrosis and minor cerebrospinal fluid leakage in 2 patients. Facial nerve recovery could be observed more than 12 months after ...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Miki Kambe Kazunobu Hashikawa Keisuke Takanari Shunjiro Yagi Kazuhiro Toriyama Katsumi Ebisawa Naoki Nishio Takashi Maruo Nobuaki Mukoyama Yasushi Fujimoto Masazumi Fujii Kiyoshi Saito Masakatsu Takahashi Yuzuru Kamei Source Type: research
Optimized radiotherapy treatment strategy for early glottic carcinoma
Nagoya J Med Sci. 2023 May;85(2):241-254. doi: 10.18999/nagjms.85.2.241.ABSTRACTThe local control rates of T1 bulky and T2 glottic carcinoma treated via radiation therapy alone are unsatisfactory; thus, we aimed to evaluate the efficacy and safety of our treatment protocol for early glottic carcinoma. Patients with early glottic squamous cell carcinoma treated via radiation therapy from January 2007 to November 2019 were reviewed. Patients were treated with: 63-67.5 Gy/28-30 fractions of radiation therapy alone for T1 non-bulky; concurrent chemoradiotherapy with S-1 and 60 Gy/30 fractions for T1 bulky and T2 favorable; and...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Tamami Ono Yoshiyuki Itoh Shunichi Ishihara Mariko Kawamura Yumi Oie Yuuki Takase Masayuki Okumura Hidekazu Oyoshi Naoya Nagai Shinji Naganawa Source Type: research
Infertility treatment for patients having a microdeletion of azoospermic factor (AZF)
Nagoya J Med Sci. 2023 May;85(2):233-240. doi: 10.18999/nagjms.85.2.233.ABSTRACTIn genetic causes of male infertility, Y chromosome microdeletions are the second most common after Klinefelter's syndrome. Although sperm recovery rate is relatively high for subjects with azoospermic factor (AZF) c chromosome microdeletion, intracytoplasmic sperm injection (ICSI) results using retrieved sperm has been reported to be poor. We retrospectively examined the infertility treatment for subjects with AZF microdeletion. From October 2017 to September 2020, chromosomal examination of 67 azoospermic subjects and 12 cryptozoospermia were...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Hatsuki Hibi Miho Sugie Megumi Sonohara Noritaka Fukunaga Yoshimasa Asada Source Type: research
Usefulness of an online learning program for new nursing faculty members
Nagoya J Med Sci. 2023 May;85(2):319-332. doi: 10.18999/nagjms.85.2.319.ABSTRACTThe purpose of this study was to examine the usefulness of an online learning program, Learning Program for New Faculty Members, in conveying knowledge of educational practice to newly appointed nursing faculty members. The study participants were assistant professors and research associates from nursing programs in Japan, with less than 5 years of educational experience. In total, 99 people participated in this study, and data from 97 were analyzed. Participants in the control group (43) were frequency matched to those in the intervention grou...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Nahoko Nakagawa Toyoaki Yamauchi Source Type: research
Bilateral variation of the parotid gland in cadaver: a case report
In this study, we present a 91-year-old female cadaver with aplasia of the parotid gland on the left side of the face and hypoplasia of the parotid gland on the right side of the face. The accessory parotid glands on both sides were of normal size, while bilateral submandibular glands were found to be larger than normal. The surgical anatomy of the parotid gland is very important because this region of the face is a complex structure intertwined with important vessels and nerves. Patients with aplasia, atresia, agenesis, or hypoplasia of the parotid gland should be diagnosed early and proper treatment must be planned. Cons...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Serpil Cilingiroglu Anli Zuhal Kazak Source Type: research
Significance of an augmented response on cervical vestibular evoked myogenic potential testing in Meniere's disease
Nagoya J Med Sci. 2023 May;85(2):375-379. doi: 10.18999/nagjms.85.2.375.ABSTRACTThe potential mechanism of augmented response on cervical vestibular evoked myogenic potential (cVEMP) testing and its decrease following treatment in a patient with Meniere's disease (MD) are discussed. Changes of static posturography and cVEMP testing before and after a glycerol drip in a 69-year-old man with unilateral MD, in which significant endolymphatic hydrops (EH) was confirmed on magnetic resonance imaging (MRI) on the diseased side, were evaluated. Values of total locus lengths, areas of postural sway, and their Romberg ratios were d...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Masumi Kobayashi Naomi Katayama Tadao Yoshida Satofumi Sugimoto Shinji Naganawa Michihiko Sone Source Type: research
Pilot study: bioequivalence of dihydroartemisinin in dihydroartemisinin-piperaquine tablet generic formulation in healthy Indonesian volunteers
Nagoya J Med Sci. 2023 May;85(2):265-274. doi: 10.18999/nagjms.85.2.265.ABSTRACTBioequivalence test should be carried out for copy medicine, including dihydroartemisinin-piperaquine (DHP), which is used to treat critical diseases requiring medication. To predict the bioequivalence of film coated DHP generic tablets compared to the reference, a randomized controlled trial, single blind, single dose cross over design, two sequences, 2 periods, and wash-out period 7 days was conducted on 8 healthy adults. Blood samples were taken at certain times; plasma levels of dihydroartemisinin (DHA) were determined and analyzed for phar...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Ani Isnawati Retno Gitawati Sukmayati Alegantina Herni Asih Setyorini Source Type: research
An extremely rare missense mutation of the androgen receptor gene in a Vietnamese family with complete androgen insensitivity syndrome
We report a Vietnamese family with complete androgen insensitivity syndrome that included several phenotypic females who have a 46,XY karyotype with an extremely rare mutation of the androgen receptor gene. The proband was a 27-year-old phenotypic adult female referred to our department for karyotyping due to primary amenorrhea. Ultrasound examination revealed a small uterus. Chromosomal analysis showed a 46,XY karyotype. A polymerase chain reaction assay revealed the presence of the sex-determining region Y gene. Next-generation sequencing detected the NM_000044.6(AR):c.2170C>T(p.Pro274Ser) mutation, which was confirme...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Thi Minh Thi Ha Phan Tuong Quynh Le Thanh Nha Uyen Le Thi Thuy Yen Hoang Source Type: research
＜Editors' Choice＞ Hook plate fixation versus locking plate fixation for distal clavicle fracture: a multicenter propensity score-matched study
Nagoya J Med Sci. 2023 May;85(2):223-232. doi: 10.18999/nagjms.85.2.223.ABSTRACTHook plate fixation and locking plate fixation are two standard internal fixation implants for treating distal clavicle fractures. We aimed to clarify the following: 1) Does the locking plate offer better clinical outcomes than the hook plate? 2) Is bone union better with a locking plate than hook plate? and 3) Are complications different between the locking plate and hook plate? We conducted a retrospective multicenter study of 338 patients who underwent surgery from 2014 to 2018 in our 10 hospitals, which comprise the TRON group. Of them, 208...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Hiroshi Takahashi Yasuhiko Takegami Katsuhiro Tokutake Yujiro Katayama Shiro Imagama Source Type: research
A case of middle cerebral artery large circumferential aneurysm treated with bypass-assisted trapping surgery
We report a case involving a ruptured large M1 circumferential aneurysm that was treated with bypass-assisted trapping surgery and showed favorable outcomes. The patient was a 47-year-old man presenting with subarachnoid hemorrhage. Digital subtraction angiography revealed a large circumferential aneurysm in the right middle cerebral artery M1 segment with involvement of the lateral and medial LSAs. We successfully performed trapping surgery with the assistance of a superficial temporal artery (STA)-M2 bypass while preserving the medial and lateral LSAs. Although left hemiparesis caused by medial LSA thrombosis appeared in...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Yusuke Sakamoto Kenko Maeda Masaya Takemoto Jungsu Choo Mizuka Ikezawa Ohju Fujita Fumihiro Sago Daiki Somiya Akira Ikeda Source Type: research
The role of inflammatory biomarkers in predicting primary acquired nasolacrimal duct obstruction and postoperative recurrence
This study aims to determine the relationship between systemic inflammatory biomarkers and primary acquired nasolacrimal duct obstruction and to evaluate whether they can be used as indicators in determining the risk of recurrence after dacryocystorhinostomy. This retrospective, comparative case series was conducted with 57 primary acquired nasolacrimal duct obstruction patients and 58 age- and gender-matched controls. All subjects underwent a complete ophthalmologic examination and complete blood count measurements. The mean neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammation ind...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: R üveyde Garip Ahmet K ürşad Sakallıoğlu Source Type: research
Changes in medical costs for adolescent idiopathic scoliosis over the past 15 years
Nagoya J Med Sci. 2023 May;85(2):333-342. doi: 10.18999/nagjms.85.2.333.ABSTRACTUse of instrumentation has become widespread in spinal surgery due to intraoperative spinal cord monitoring, navigation, and improvement and development of implant materials. However, recent advances in spine surgery may have also led to an increase in medical costs. The purpose of this study is to investigate the trends of operative resource utilization and the costs of surgery for adolescent idiopathic scoliosis (AIS) over 15 years. Surgery for AIS was performed for 118 patients from January 2004 to December 2019 at national University Hospit...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Kazuyoshi Kobayashi Koji Sato Toshihiro Ando Shiro Imagama Source Type: research
Secondary aneurysmal bone cyst of the frontal bone with fibrous dysplasia showing rapid expansion: a case report
Nagoya J Med Sci. 2023 May;85(2):395-401. doi: 10.18999/nagjms.85.2.395.ABSTRACTA 19-year-old woman presented with swelling of the left forehead without pain. She did not have any relevant past or family history. Computed tomography showed destruction of the outer cortex of the frontal bone. A solitary mass lesion with a fluid collection was detected with magnetic resonance imaging. Because the swelling of the left forehead had enlarged rapidly with osteolytic changes, surgical removal of the lesion was performed. The lesion appeared to be enveloped in a fibrous capsule. The soft lesion was removed from the frontal bone. T...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Yuta Koketsu Takafumi Tanei Kyoko Kuwabara Toshinori Hasegawa Takenori Kato Satoshi Maesawa Yusuke Nishimura Yoshio Araki Ryuta Saito Source Type: research
Eighteen-years follow-up of congenital hypothyroidism by < em > TSHR < /em > gene p.Arg109Gln and p.Arg450His variants
Nagoya J Med Sci. 2023 May;85(2):369-374. doi: 10.18999/nagjms.85.2.369.ABSTRACTCongenital hypothyroidism (CH) is a common heterogeneous endocrine disorder. The thyroid-stimulating hormone receptor gene (TSHR) is one of the major candidate genes associated with CH. Studies have investigated the possible correlations between the specific clinical features and the presence of TSHR variants. However, only a few reports have focused on the long-term follow-up of patients with CH. Here we present a case of CH-associated TSHR p.Arg109Gln and p.Arg450His rare compound heterozygous variants, with a follow-up performed until adoles...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Daisuke Watanabe Hideaki Yagasaki Yumiko Mitsui Takeshi Inukai Source Type: research
Relationship between gait stability indices and gait parameters comprising joint angles based on walking data from 288 people
In this study, we calculated the margin of stability (MoS) and the maximum Lyapunov exponent (λs), which are two major stability indices for walking, using a gait database representing 300 healthy people. Previously, the relationships between these indices and other gait parameters, including joint angles, have not been investigated in such a large subject pool. Therefore, we determined the relationships between these stability indices and the gait parameters by calculating correlation coefficients and performing multiple regression analysis. The results indicated that MoS is dominated by walking speed in the forward dire...
Source: Nagoya Journal of Medical Science - June 22, 2023 Category: International Medicine & Public Health Authors: Takashi Inagaki Yasuhiro Akiyama Shogo Okamoto Takuya Mayumi Yoji Yamada Source Type: research
