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Source: Journal of Medical Investigation
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Total 20239 results found since Jan 2013.
Inhibitory Effects of Aspirin and Cilostazol on Intracellular Ca < sup > 2+ < /sup > Mobilization and Aggregation in Thrombin-activated Human Platelets
J Med Invest. 2023;70(1.2):94-100. doi: 10.2152/jmi.70.94.ABSTRACTPlatelets play an important role in physiological hemostatic mechanisms. In contrast, platelet activation has been implicated in pathological conditions, such as atherosclerosis, angiogenesis, and inflammation. Thrombin is considered to be of particular pathological importance as a platelet-activating substance, and thrombin-activated platelets are detected in the blood of patients with advanced occlusive arterial disease. Ca2+ acts as a second messenger in platelet activation, and the regulation of intracellular Ca2+ concentrations ([Ca2+]i) is important fo...
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Atsumi Sone Kensaku Aki Toshiyuki Yasui Eiji Hosoi Source Type: research
Validation of the Japanese version of the 8-item Chronic Pain Acceptance Questionnaire (CPAQ-8)
This study aimed to examine the reliability and validity of the Japanese version of the Chronic Pain Acceptance Questionnaire (CPAQ-8J). A total of 108 outpatients with chronic pain completed the CPAQ-8 questionnaire, along with the Acceptance and Action Questionnaire-II, Hospital Anxiety and Depression Scale, Pain Disability Assessment Scale, Numerical Rating Scale, and EuroQol 5 dimensions 5-level. Confirmatory factor analyses examined the factor structure. Results indicated that the CPAQ-8J comprised a two-component factor structure. Correlations between the CPAQ-8J and each variable were as expected, except between the...
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Takaki Fukumori Kengo Fujishima Kazunori Iwasa Yumiko Takao Yukino Kobayashi Hiroyuki Nishie Source Type: research
The impact of nutritional status and changes of body composition on the prognosis of metastatic renal cell carcinoma patients
CONCLUSIONS: Nutritional status of mRCC patients may predict changes in body composition and be associated with their prognosis. J. Med. Invest. 70 : 80-87, February, 2023.PMID:37164748 | DOI:10.2152/jmi.70.80
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Keisuke Ozaki Tomoya Fukawa Kei Daizumoto Yutaro Sasaki Yoshiteru Ueno Megumi Tsuda Takayuki Uchida Yoshito Kusuhara Yasuyo Yamamoto Kunihisa Yamaguchi Masayuki Takahashi Hiro-Omi Kanayam Source Type: research
Effect of 10-minute prewarming plus intraoperative co-warming on core temperature maintenance during breast surgery compared to intraoperative co-warming alone: a randomized controlled trial
CONCLUSIONS: Ten-min prewarming decreases core temperature loss and contribute to maintaining normal core temperature during breast surgery. J. Med. Invest. 70 : 74-79, February, 2023.PMID:37164747 | DOI:10.2152/jmi.70.74
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Ryosuke Kawanishi Yasuhito Honda Yutaro Bando Nami Kakuta Katsuya Tanaka Source Type: research
METS-IR vs. HOMA-AD and Metabolic Syndrome in Obese Adolescents
CONCLUSION: METS-IR is better surrogate to determine MetS with cut-off point of???46.53, while HOMA-AD is better to determine IR with cut-off point???0.37 in obese adolescents. J. Med. Invest. 70 : 7-16, February, 2023.PMID:37164746 | DOI:10.2152/jmi.70.7
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Nur Aisiyah Widjaja Roedi Irawan Meta Herdiana Hanindita Idg Ugrasena Retno Handajani Source Type: research
Effect of daikenchuto (TU-100) on carcinogenesis in non-alcoholic steatohepatitis
CONCLUSIONS: TU-100 regulates the intestinal microbiome and may suppress subsequent hepatocarcinogenesis in the NASH model. J. Med. Invest. 70 : 66-73, February, 2023.PMID:37164745 | DOI:10.2152/jmi.70.66
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Shinichiro Yamada Yuji Morine Satoru Imura Tetsuya Ikemoto Yu Saito Mayuko Shimizu Koichi Tsuneyama Mitsue Nishiyama Shiori Ishizawa Mitsuo Shimada Source Type: research
Goishi tea leaf powder affects lower body weight and visceral fat accumulation during energy restriction in obese rats
In conclusion, the administration of Goishi tea leaves under dietary restrictions might contribute to body weight reduction and inhibition of lipid absorption, as a diet therapy to help prevent obesity and metabolic syndrome. J. Med. Invest. 70 : 60-65, February, 2023.PMID:37164744 | DOI:10.2152/jmi.70.60
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Takahiro Seura Tomomi Kanno Yoshiaki Miyake Misako Sogawa Source Type: research
Associations of serum leptin levels with intra-articular inflammatory cytokine levels in acute arthritic and nonarthritic knees of mice
CONCLUSIONS: Hyperleptinemia induced by a HFD is involved in low-grade intra-articular inflammation in nonarthritic knee joints. In contrast, leptin deficiency causes excessive intra-articular inflammation in carrageenan-induced acute arthritis. Leptin alleviates acute arthritis, while chronic hyperleptinemia is involved in low-grade inflammation in normal knee joints. J. Med. Invest. 70 : 54-59, February, 2023.PMID:37164743 | DOI:10.2152/jmi.70.54
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Koji Aso Shogo Takaya Yusuke Kasai Masashi Izumi Masahiko Ikeuchi Source Type: research
Benefits of guideline-directed medical therapy to loop diuretics in management of heart failure
CONCLUSIONS: Our data indicate the benefits of guideline-directed medical therapy to loop diuretics in the management of HF. J. Med. Invest. 70 : 41-53, February, 2023.PMID:37164742 | DOI:10.2152/jmi.70.41
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Kenya Kusunose Yuichiro Okushi Yoshihiro Okayama Robert Zheng Michikazu Nakai Yoko Sumita Takayuki Ise Koji Yamaguchi Shusuke Yagi Hirotsugu Yamada Takeshi Soeki Tetsuzo Wakatsuki Masataka Sata Source Type: research
Effect of Dietary Counseling on Patients with Asymptomatic Hyperuricemia
This study aimed to evaluate the effectiveness of dietary counseling following the guideline. Thirty-three subjects (24 men and 9 women) with asymptomatic hyperuricemia underwent dietary counseling for 6 months based on the following recommendations : (1) prevent excessive purine intake, (2) prevent excessive fructose intake, (3) limit alcohol drinking, and (4) drink sufficient water. Obese subjects were counseled on adequate energy intake. Blood sampling, anthropometric measurements, dietary surveys, and 24-h urine collection were performed at baseline and at 6 months. Serum uric acid (S-UA) levels were significantly lowe...
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Risa Koike Yuka Kawakami Riho Kondo Misaki Onishi Misuzu Akiyama Toshihiko Asai Hidekazu Arai Source Type: research
Repetitive postoperative extubation failure due to dynamic inspiratory airway collapse concomitant with subglottic stenosis in a patient who previously underwent tracheostomy
CONCLUSIONS: We should be aware of the history of tracheostomy, especially at high tracheostomy sites, even in the absence of respiratory symptoms as risk factors for dynamic inspiratory airway collapse concomitant with subglottic stenosis contributing to repeated respiratory failure after extubation. J. Med. Invest. 70 : 301-305, February, 2023.PMID:37164740 | DOI:10.2152/jmi.70.301
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Yuki Nakano Yoshitoyo Ueno Emi Ishitani Koji Sato Hiroki Sato Kazuki Momota Natsuki Bando Yusuke Akimoto Toshiyuki Nunomura Manabu Ishihara Natsuki Tane Taiga Itagaki Yoshiaki Kitamura Jun Oto Source Type: research
Case study of a migraine patient with multiple extracephalic symptoms including melena due to telangiectasia of the sigmoid colon : a possible new migraine-associated symptom
In this report, we discuss a possible mechanism for melena due to telangiectasia in migraine patients, as well as "tips" for identifying subtle and/or unreported clinical features of migraine conditions. J. Med. Invest. 70 : 298-300, February, 2023.PMID:37164739 | DOI:10.2152/jmi.70.298
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Yosuke Kakisaka Hiroshi Ishii Source Type: research
A pediatric case of infliximab-resistant ulcerative colitis successfully treated using vedolizumab
J Med Invest. 2023;70(1.2):294-297. doi: 10.2152/jmi.70.294.ABSTRACTPediatric ulcerative colitis is likely to be more severe than adult ulcerative colitis. Failure to thrive should be considered during therapy. A 10-year-old boy was diagnosed with ulcerative colitis based on his clinical presentation and colonoscopy and biopsy results. The administration of 5-aminosalicylic acid and prednisolone resulted in remission ; however, the symptoms reappeared after the discontinuation of prednisolone. Then, infliximab was administered ; however, the patient was resistant to it and appeared to be dependent on prednisolone. Vedolizu...
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Shoko Fukura Mikiko Takei Shunsuke Takeuchi Takahiro Tayama Akemi Ono Yuko Ichihara Koichi Shichijo Yasuhiro Suzuki Kazuhiro Mori Shuji Kondo Source Type: research
A case of complete decapitation in suicidal hanging : the mechanism and condition of decapitation
We report the case of a decapitated man who was found in the sea near an estuary. A polyethylene rope was tied to the handrail of the bridge across a strait near the site of the body. The rope was 12 mm in diameter and 19 m in length from the handrail. It ended with a slip knot noose, and skin and mustache-like hair fragments were attached to it. The decapitated head was not found. The deceased weighed 82 kg and was 152 cm long without the head. The autopsy revealed coarse abrasions and intramuscular hemorrhage around the severed edge. The third cervical spine was not fractured. We reviewed the literature and suggested the...
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Asuka Ito Hideyuki Nushida Hiromitsu Kurata Hitomi Umemoto Hirofumi Iseki Itsuo Tokunaga Akiyoshi Nishimura Source Type: research
Laparoscopic pancreaticoduodenectomy in patients with a history of right hemicolectomy : A report of three cases
In conclusion, LPD following RHC may be safely completed with laparoscopy. J. Med. Invest. 70 : 285-289, February, 2023.PMID:37164736 | DOI:10.2152/jmi.70.285
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Hayato Ohya Atsuyuki Maeda Yuichi Takayama Takamasa Takahashi Hiroki Aoyama Takahiro Hosoi Kazuaki Seita Yuji Kaneoka Source Type: research
