Filtered By:
Source: Molecular Medicine Reports

This page shows you your search results in order of relevance. This is page number 8.

Order by Relevance | Date

Total 308 results found since Jan 2013.

Parathyroid hormone 1 ‑34 inhibits senescence in rat nucleus pulposus cells by activating autophagy via the m‑TOR pathway.
Parathyroid hormone 1‑34 inhibits senescence in rat nucleus pulposus cells by activating autophagy via the m‑TOR pathway. Mol Med Rep. 2018 Jun 27;: Authors: Wang XY, Jiao LY, He JL, Fu ZA, Guo RJ Abstract Osteoporosis is closely associated with intervertebral disc degeneration. While parathyroid hormone (PTH) 1‑34, which is an established drug used to treatosteoporosis, is thought to inhibit the disc degeneration associated with osteoporosis, the precise mechanism involved remains unclear. In the present study, primary Sprague‑Dawley rat nucleus pulposus cells (NPCs) were cultured, phenotyped...
Source: Molecular Medicine Reports - July 1, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Melatonin protects H9c2 cells against ischemia/reperfusion ‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway.
Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway. Mol Med Rep. 2018 Jul 24;: Authors: Zhang Y, Qiao B, Gao F, Wang H, Miao S, Zhao H Abstract Melatonin can protect against cardiac ischemia/reperfusion (I/R) injury in models in vitro and in vivo by regulating oxidative stress and apoptosis; however, the precise molecular mechanisms involved remain unclear. Nuclear factor erythroid 2‑related factor 2 (Nrf2) is a transcription factor, which has been associated with the regulation of oxidative stress by tran...
Source: Molecular Medicine Reports - August 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Lentiviral ‑mediated inducible silencing of TLR4 attenuates neuropathic pain in a rat model of chronic constriction injury.
In conclusion, TLR4 may serve a significant role in neuropathy and the results of the present study provide an inducible lentivirus‑mediated siRNA against TLR4 that may serve as a potential novel strategy to be applied in gene therapy for NP in the future. PMID: 30365084 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - October 27, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

circRNA ‑CER mediates malignant progression of breast cancer through targeting the miR‑136/MMP13 axis.
circRNA‑CER mediates malignant progression of breast cancer through targeting the miR‑136/MMP13 axis. Mol Med Rep. 2019 Feb 18;: Authors: Qu Y, Dou P, Hu M, Xu J, Xia W, Sun H Abstract Chondrocyte extracellular matrix‑related circular RNAs (circRNA‑CER) have been demonstrated to be involved in various diseases. However, its role in the development of human breast cancer is not clearly understood. The aims of the present study were to assess circRNA‑CER expression in paired cancer tissue and adjacent non‑tumor tissue from 24 patients with breast cancer, and to explore the roles and mechani...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Knockdown of serpin peptidase inhibitor clade C member  1 inhibits the growth of nasopharyngeal carcinoma cells.
Knockdown of serpin peptidase inhibitor clade C member 1 inhibits the growth of nasopharyngeal carcinoma cells. Mol Med Rep. 2019 Mar 14;: Authors: Xu J, Ying Y, Xiong G, Lai L, Wang Q, Yang Y Abstract Nasopharyngeal carcinoma (NPC) is a type of cancer originating in the nasopharynx. There are no NPC‑specific treatments available at present. Serpin peptidase inhibitor clade C member 1 (SERPINC1) serves roles in anticoagulation and anti‑inflammation. The aim of the present study was to investigate the role of SERPINC1 in the proliferation and apoptosis of NPC cells. Tumor and adjacent healthy ti...
Source: Molecular Medicine Reports - March 23, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial ‑mesenchymal transition.
FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition. Mol Med Rep. 2019 Mar 27;: Authors: Luo YD, Ding X, Du HM, Wu YN, Li HQ, Wu HM, Zhang XM Abstract Although forkhead box protein M1 (FOXM1) is markedly upregulated in human premalignant and oral squamous cell carcinoma (OSCC) tissues and cultured cells, the association of FOXM1 expression with OSCC prognosis is not well understood. The present study investigated the possible association of FOXM1 expression in patients with OSCC with their clinicopatho...
Source: Molecular Medicine Reports - April 5, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑214 upregulates HIF‑1α and VEGF by targeting ING4 in lung cancer cells.
In conclusion, it was demonstrated that miR‑214 targeted ING4 in lung cancer cells, and upregulated the HIF‑1α cascade, leading to MMP2 and VEGF upregulation. This approach may help to clarify the role of miRNA in non‑small lung cancer and may be a new therapeutic target for non‑small lung cancer. PMID: 31059086 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - May 8, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Role of feline sarcoma ‑related protein in the viability and apoptosis of bladder cancer cells.
Role of feline sarcoma‑related protein in the viability and apoptosis of bladder cancer cells. Mol Med Rep. 2019 Apr 30;: Authors: Hu X, Guo Z, Xu J, Mei X, Bi M, Jiang F, Yu D, Zhong C Abstract Feline sarcoma‑related protein (Fer) is a type of nuclear and cytoplasmic non‑receptor protein tyrosine kinase, which is associated with the progression of numerous types of cancer. Previously, we identified that Fer is associated with the migration and invasion of bladder cancer. The present study aimed to investigate the role of Fer in bladder cancer cell viability and apoptosis. Reverse transcriptionâ€...
Source: Molecular Medicine Reports - May 8, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Mechanism of interactions between endoplasmic reticulum stress and autophagy in hypoxia/reoxygenation ‑induced injury of H9c2 cardiomyocytes.
Mechanism of interactions between endoplasmic reticulum stress and autophagy in hypoxia/reoxygenation‑induced injury of H9c2 cardiomyocytes. Mol Med Rep. 2019 May 09;: Authors: Guan G, Yang L, Huang W, Zhang J, Zhang P, Yu H, Liu S, Gu X Abstract Endoplasmic reticulum (ER) stress and autophagy are involved in myocardial ischemia‑reperfusion (I/R) injury; however, their roles in this type of injury remain unclear. The present study investigated the roles of ER stress and autophagy, and their underlying mechanisms, in H9c2 cells during hypoxia/reoxygenation (H/R) injury. Cell viability was detected b...
Source: Molecular Medicine Reports - May 23, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Corrigendum Knockdown of lncRNA  HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma.
[Corrigendum] Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma. Mol Med Rep. 2019 Jun 11;: Authors: Zhu W, Zhuang P, Song W, Duan S, Xu Q, Peng M, Zhou J Abstract Following the publication of the article, the authors noted an error associated with the presentation of Fig. 3B. This Figure part showed the cell cycle analysis as determined by flow cytometry of HT29 cells transfected with either a HNF1A-AS1-specific siRNA or a negative control siRNA at 48 h post-transfection. An error was made in the compilation of this Figure, and the same data were inadvertently sel...
Source: Molecular Medicine Reports - July 2, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

RIPK3 mediates renal tubular epithelial cell apoptosis in endotoxin ‑induced acute kidney injury.
RIPK3 mediates renal tubular epithelial cell apoptosis in endotoxin‑induced acute kidney injury. Mol Med Rep. 2019 Jun 24;: Authors: Zhang S, Li R, Dong W, Yang H, Zhang L, Chen Y, Wang W, Li C, Wu Y, Ye Z, Zhao X, Li Z, Zhang M, Liu S, Liang X Abstract Renal tubular epithelial cell apoptosis is an important pathological mechanism of septic acute kidney injury (AKI). Endotoxin, also known as lipopolysaccharide (LPS), has a key role in septic AKI and can directly induce tubular epithelial cell apoptosis. The upregulation of receptor‑interacting protein kinase 3 (RIPK3) in tubular epithelial cells ha...
Source: Molecular Medicine Reports - July 2, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MPZL1 is highly expressed in advanced gallbladder carcinoma and promotes the aggressive behavior of human gallbladder carcinoma GBC ‑SD cells.
In conclusion, the present study showed that the expression and protein levels of MPZL1 were significantly higher in gallbladder carcinoma tissues, especially in patients diagnosed with advanced tumor stages. Overexpression of MPZL1 may have promoted the invasion, metastasis, proliferation and survival of GBC‑SD cells. PMID: 31322261 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - July 21, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Lentiviral ‑mediated Shh reverses the adverse effects of high glucose on osteoblast function and promotes bone formation via Sonic hedgehog signaling.
Lentiviral‑mediated Shh reverses the adverse effects of high glucose on osteoblast function and promotes bone formation via Sonic hedgehog signaling. Mol Med Rep. 2019 Jul 31;: Authors: Jiang ZL, Jin H, Liu ZS, Liu MY, Cao XF, Jiang YY, Bai HD, Zhang B, Li Y Abstract Patients with diabetes tend to have an increased incidence of osteoporosis, which may be associated with hyperglycemia; however, the pathogenic mechanisms governing this interaction remain unknown. The present study sought to investigate whether elevated extracellular glucose levels of bone mesenchymal stem cells (BMSCs) could influence ...
Source: Molecular Medicine Reports - August 22, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Silencing of CD86 in dendritic cells by small interfering RNA regulates cytokine production in T cells from patients with allergic rhinitis in  vitro.
Silencing of CD86 in dendritic cells by small interfering RNA regulates cytokine production in T cells from patients with allergic rhinitis in vitro. Mol Med Rep. 2019 Sep 02;: Authors: Sun R, Yang Y, Gu Z, Tang X, Zhang C, Kou W, Wei P Abstract The aim of the present study was to investigate the expression and role of the co‑stimulatory molecule T‑lymphocyte activation antigen CD86 (CD86) in dendritic cells (DCs) from the peripheral blood of patients with allergic rhinitis (AR) compared with those from healthy individuals. It was observed that mature DCs from the peripheral blood of patients with...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effects of hypoxia ‑inducible factor‑1α on the proliferation and apoptosis of human synovial mesenchymal stem cells.
In conclusion, HIF‑1α effectively improved the tolerance of SMSCs to hypoxia, which may promote cellular proliferation and prevent the apoptosis of SMSCs under hypoxic conditions. PMID: 31545415 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 24, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research