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Source: Molecular Medicine Reports
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Total 308 results found since Jan 2013.
Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury
In conclusion, the results of the present study demonstrated that chronic alcohol consumption worsened lung injury by aggravating pulmonary edema and impairing AFC. An alcohol‑induced decrease of α‑ENaC, β‑ENaC and γ‑ENaC expression levels by the A2AR‑mediated cAMP pathway may be responsible for the exacerbated effects of chronic alcohol consumption in lung injury.PMID:34396442 | DOI:10.3892/mmr.2021.12364
Source: Molecular Medicine Reports - August 16, 2021 Category: Molecular Biology Authors: Wang Deng Jing He Xu-Mao Tang Chang-Yi Li Jin Tong Di Qi Dao-Xin Wang Source Type: research
Silencing of PFKFB3 protects podocytes against high glucose ‑induced injury by inducing autophagy
In conclusion, silencing of PFKFB3 may protect podocytes from HG‑induced injury by inducing autophagy. Therefore, PFKFB3 may serve as a potential target for treatment of DN.PMID:34490476 | DOI:10.3892/mmr.2021.12405
Source: Molecular Medicine Reports - September 7, 2021 Category: Molecular Biology Authors: Zhengming Zhu Qingsheng Liu Jianshi Sun Ziyang Bao Weiwei Wang Source Type: research
NF ‑κB/IκBα signaling pathways are essential for resistance to heat stress‑induced ROS production in pulmonary microvascular endothelial cells
Mol Med Rep. 2021 Nov;24(5):814. doi: 10.3892/mmr.2021.12454. Epub 2021 Sep 24.ABSTRACTThe results of a previous study demonstrated that heat stress (HS) triggered oxidative stress, which in turn induced the apoptosis of epithelial cells. These results uncovered a novel mechanism underlying the activation of NF‑κB in primary human umbilical vein endothelial cells. The present study aimed to further investigate the role of NF‑κB/IκBα signaling pathways in the inhibition of HS‑induced reactive oxygen species (ROS) generation and cytotoxicity in endothelial cells. The results of the present study demonstrated that H...
Source: Molecular Medicine Reports - September 24, 2021 Category: Molecular Biology Authors: Weidang Xie Wei Huang Shumin Cai Hui Chen Weijun Fu Zhongqing Chen Yanan Liu Source Type: research
Astaxanthin induces NADPH oxidase activation and receptor ‑interacting protein kinase 1‑mediated necroptosis in gastric cancer AGS cells
In conclusion, ASX induced necroptotic cell death by increasing NADPH oxidase activity, ROS levels, LDH release and the number of propidium iodide‑positive cells, as well as activating necroptosis‑regulating proteins, RIP1/RIP3/MLKL, in gastric cancer AGS cells. The results of this study demonstrated the necroptotic effect of ASX on gastric cancer AGS cells, which required NADPH oxidase activation and RIP1/RIP3/MLKL signaling in vitro.PMID:34608499 | DOI:10.3892/mmr.2021.12477
Source: Molecular Medicine Reports - October 5, 2021 Category: Molecular Biology Authors: Sori Kim Hanbit Lee Joo Weon Lim Hyeyoung Kim Source Type: research
