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Source: Molecular Medicine Reports

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Total 308 results found since Jan 2013.

Resveratrol improves palmitic acid ‑induced insulin resistance via the DDIT4/mTOR pathway in C2C12 cells
In conclusion, RSV may improve PA‑induced IR in C2C12 cells through the DDIT4/mTOR/IRS‑1/PI3K/AKT/GLUT4 signaling pathway, as well as via improvements in glucose and lipid metabolism.PMID:37594055 | DOI:10.3892/mmr.2023.13068
Source: Molecular Medicine Reports - August 18, 2023 Category: Molecular Biology Authors: Xinyan Pan Chunqiao Liu Xing Wang Ming Zhao Zhimei Zhang Xuemei Zhang Chao Wang Guangyao Song Source Type: research

Adiponectin affects vascular smooth muscle cell proliferation and apoptosis through modulation of the mitofusin-2-mediated Ras-Raf-Erk1/2 signaling pathway.
Authors: Zhang W, Shu C, Li Q, Li M, Li X Abstract Vascular smooth muscle cells (VSMCs) undergo cell biological changes in response to a variety of cytokines and growth factors. Adiponectin inhibits neointimal formation through suppressing the proliferation and migration of VSMCs. However, the mechanisms underlying the effect of adiponectin on VSMC proliferation and apoptosis require further investigation. The present study was designed to investigate the mechanisms of adiponectin on VSMC proliferation and apoptosis, focusing on the mitofusin‑2 (MFN2) mediated Ras‑Raf‑extracellular signal regulated kinase (Er...
Source: Molecular Medicine Reports - June 12, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Lipoteichoic acid upregulates NF-κB and proinflammatory cytokines by modulating β-catenin in bronchial epithelial cells.
Authors: Jang J, Kim W, Kim K, Chung SI, Shim YJ, Kim SM, Yoon Y Abstract Lipoteichoic acid (LTA) is a major cell wall component and virulence factor of gram-positive bacteria. The present study investigated the LTA‑induced inflammatory response of BEAS‑2B human bronchial epithelial cells, and detected the expression levels of proinflammatory cytokines interleukin (IL)‑6, IL‑8, IL‑1β, tumour necrosis factor‑α and monocyte chemotactic protein‑1, the upregulation of NF‑κB, and the phosphorylation and degradation of I‑κB. During the LTA‑induced inflammatory response of the BEAS‑2B human bronc...
Source: Molecular Medicine Reports - June 23, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathway.
In conclusion, these findings offer support for a mechanism that may underlie the anti‑neoplastic effects of curcumin and justify further investigation to examine the potential roles for activators of FOXO1 in the prevention and treatment of pancreatic cancer. PMID: 26166196 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - July 16, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

House dust mite allergens mediate the activation of c‑kit in dendritic cells via Toll‑like receptor 2.
Authors: Wu W, Wang CX, Chen H, Zhou J, Zhang JZ, Gao L, Zhou HY Abstract Several studies have demonstrated that the c‑kit proto‑oncogene and its ligand, stem cell factor, are important in the development of asthma. House dust mite (HDM; Dermatophagoides pteronyssinus) allergens are a major trigger in the development and exacerbation of asthma. HDM allergens can induce the activation of c‑kit in dendritic cells (DCs), leading to the development of allergic asthma. Previous studies have demonstrated that activation of Toll‑like receptor 2 (TLR2) evokes a T helper (Th)2 immune response and promotes experim...
Source: Molecular Medicine Reports - August 6, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Retracted Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways.
Authors: Yang G, Ma F, Zhong M, Fang L, Peng Y, Xin X, Zhong J, Zhu W, Zhang Y Abstract After the publication of the article, the authors noted that they had made errors in their research article titled 'Interleukin‑11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly through PI3K‑AKT and JAK‑STAT3 pathways'. All authors unanimously decided they wished to retract the article published in Molecular Medicine Reports 9: 1371-1375, 2014. We wish to retract the article for the following reasons. The β‑actin band in control group in figure 3, the β‑actin band in IL11+...
Source: Molecular Medicine Reports - August 6, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Adipose differentiation-related protein is not involved in hypoxia inducible factor-1-induced lipid accumulation under hypoxia.
Authors: Shen G, Ning N, Zhao X, Liu X, Wang G, Wang T, Zhao R, Yang C, Wang D, Gong P, Shen Y, Sun Y, Zhao X, Jin Y, Yang W, He Y, Zhang L, Jin X, Li X Abstract Increasing evidence has showed that hypoxia inducible factor-1 (HIF1) has an important role in hypoxia-induced lipid accumulation, a common feature of solid tumors; however, its role remains to be fully elucidated. Adipose differentiation‑related protein (ADRP), a structural protein of lipid droplets, is found to be upregulated under hypoxic conditions. In the present study, an MCF7 breast cancer cell line was used to study the role of ADRP in hypoxia‑...
Source: Molecular Medicine Reports - October 28, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Inhibition of the expression of aquaporin‑1 by RNA interference in pulmonary epithelial cells and its effects on water transport.
Authors: Zhang Q, Fu J, Xue X Abstract In the present study, the effect of aquaporin‑1 (AQP1) on fluid transportation in pulmonary epithelial cells, and the role of AQP1 in alveolar fluid clearance were investigated to provide an experimental foundation to elucidate the pathogenesis of hyperoxic lung edema. An siRNA transfection technique was used to silence AQP1 in the A549 cell line. The transfected cells were randomized into a hyperoxia exposure and an air control group, with a negative control group set for each group. Cell volume was determined using flow cytometry, and Pf values were used to determine osmo...
Source: Molecular Medicine Reports - November 10, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Survivin is expressed in degenerated nucleus pulposus cells and is involved in proliferation and the prevention of apoptosis in vitro.
Authors: Lin Y, Yue B, Xiang H, Liu Y, Ma X, Chen B Abstract Survivin is a unique inhibitor of apoptosis, which is frequently present within degenerated human nucleus pulposus (NP) cells. Survivin has been extensively investigated using proliferation and apoptosis assays in tumor cells; however, studies conducted on survivin in degenerative NP cells remain limited to date. The aim of the present study was to investigate survivin expression and its effects on the proliferation and apoptosis of degenerated NP cells in vitro. The expression levels of survivin in the NP cells of patients (>45 years) with lumbar di...
Source: Molecular Medicine Reports - December 11, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

CRMP‑5 interacts with actin to regulate neurite outgrowth.
Authors: Gong X, Tan M, Gao Y, Chen K, Guo G Abstract CRMP family proteins (CRMPs) are abundantly expressed in the developing nervous system mediating growth cone guidance, neuronal polarity and axon elongation. CRMP‑5 has been indicated to serve a critical role in neurite outgrowth. However, the detailed mechanisms of how CRMP‑5 regulates neurite outgrowth remain unclear. In the current study, co‑immunoprecipitation was used to identify the fact that CRMP‑5 interacted with the actin and tubulin cytoskeleton networks in the growth cones of developing hippocampal neurons. CRMP‑5 exhibited increased affinit...
Source: Molecular Medicine Reports - December 20, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin‑induced cell death.
Authors: Wu J, Chi L, Chen Z, Lu X, Xiao S, Zhang G, Luo J, Chen GM, Yang J Abstract The TMPRSS2:E‑twenty‑six (ETS) gene fusion occurs frequently in a high proportion of patients with prostate cancer (PCa) in Western countries, and the aberrant expression of TMPRSS2: v‑ETS avian erythroblastosis virus E26 oncogene homolog (ERG), the most common form of the corresponding protein, can regulate cell migration and contribute to tumor invasion and metastasis. However, its association with other cellular events, and in particular, cell death, remain unknown. To examine the function of such fusion genes, an expressi...
Source: Molecular Medicine Reports - March 6, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

miR‑19a‑3p targets PMEPA1 and induces prostate cancer cell proliferation, migration and invasion.
In conclusion, the findings of the present study suggest that the upregulation of miR‑19a‑3p expression levels contributes to tumor progression and that one of its underlying mechanisms involves inhibition of PMEPA1 expression. PMID: 27035427 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - April 3, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

TLR2/NFκB signalling regulates endogenous IL-6 release from marrow-derived mesenchymal stromal cells to suppress the apoptosis of PC12 cells injured by oxygen and glucose deprivation.
In conclusion, the release of IL‑6 from MSCs was regulated via the TLR2/NFκB signalling pathway. Endogenous IL‑6 reduced apoptosis and protected OGD‑injured PC12 cells when they were co‑cultured with MSCs. The present study has reported a novel immunomodulatory effect of the microenvironment of neural damage during MSC cytotherapy. PMID: 27108485 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - April 27, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

TRIM59 is upregulated and promotes cell proliferation and migration in human osteosarcoma.
Authors: Liang J, Xing D, Li Z, Shen J, Zhao H, Li S Abstract Osteosarcoma is a prevalent type of cancer and has a high metastatic ability, particularly for metastasis to the lungs. Effective treatment strategies have improved, however, the detailed molecular mechanism underlying the onset of this malignancy remains to be fully elucidated. The current study investigated the role of the tripartite motif (TRIM) family protein TRIM59 in osteosarcoma growth and metastasis. It was identified that TRIM59 was overexpressed in clinical osteosarcoma tissues and cultured osteosarcoma cell lines. In addition, the MTT assay de...
Source: Molecular Medicine Reports - April 30, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Expression of NLRC4 in children with septicaemia and mechanisms of NLRC4 in in vitro cytokine secretion.
Authors: Zhu G, Chen J, Tian J, Ge L, Xing A, Tang G Abstract Septicaemia, a systemic bacterial infection, frequently leads to morbidity and mortality in children. The NOD-like receptor (NLR) family, CARD domain containing 4 (NLRC4) is involved in the control of infections. The aim of the present study was to detect the expression of NLRC4 in the blood samples of children with septicaemia, in addition to investigating the importance of NLRC4 in cytokine production, and the signaling pathways that regulate NLRC4 expression in lipopolysaccharide (LPS)-stimulated macrophages. It was determined that when compared with...
Source: Molecular Medicine Reports - May 15, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research