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Source: Molecular Medicine Reports

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Total 308 results found since Jan 2013.

Knockdown of ZEB1 suppressed the formation of vasculogenic mimicry and epithelial-mesenchymal transition in the human breast cancer cell line MDA-MB-231.
Authors: Liang W, Song S, Xu Y, Li H, Liu H Abstract Breast cancer is a common malignant tumor in women. It has been suggested that a type of microcirculation pattern that does not rely on host microvascular endothelial cells known as vasculogenic mimicry (VM) may contribute to the poor effect of anti‑angiogenesis treatment on some patients with breast cancer. However, the formation and regulatory mechanism of VM in breast cancer are unclear and still require further investigation. The present study examined whether decreasing the expression of zinc finger E‑box binding homeobox (ZEB1) using siRNA can inhibit t...
Source: Molecular Medicine Reports - March 9, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Inhibition of autophagy promotes cisplatin-induced apoptotic cell death through Atg5 and Beclin 1 in A549 human lung cancer cells.
In conclusion, the present study demonstrated that targeting autophagy may be used in the future for the treatment of lung cancer. PMID: 29512762 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - March 9, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

HIF-1-mediated expression of Foxo1 serves an important role in the proliferation and apoptosis of osteoblasts derived from children's iliac cancellous bone.
Authors: Xu G Abstract Activation of the transcription factor hypoxia inducible factor‑1α (HIF-1α) is considered critical for the stimulation of osteogenic markers including runt‑related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin, which are closely associated with forkhead boxclass O1 (Foxo1) levels in osteoblasts. The present study explored the associations between HIF‑1α and Foxo1 in the regulation of cell viability, proliferation and apoptosis of osteoblasts. Osteoblasts obtained from children's iliac cancellous bone were used in the present study, which were confirmed b...
Source: Molecular Medicine Reports - March 9, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression.
Authors: Zhu J, Ren J, Tang L Abstract Colon cancer is characterized by invasion and migration. DNA methylation of CpG islands in tumor suppressor genes is considered to be an epigenetic mechanism underlying cancer development. Epigenetic silencing of a gene may be reversed by drugs, including genistein. The present study aimed to determine the effect of genistein on Wnt inhibitory factor 1 (WIF1) and invasion, and migration of colon cancer cells. The viability of HT29 colon cancer cells was suppressed by genistein in a dose dependent manner. Following 72 h of treatment with 10, 20 and 60 µmol/l genistein, incre...
Source: Molecular Medicine Reports - March 25, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Downregulation of lncRNA H19 inhibits migration and invasion of human osteosarcoma through the NF- κB pathway.
Downregulation of lncRNA H19 inhibits migration and invasion of human osteosarcoma through the NF-κB pathway. Mol Med Rep. 2018 Mar 14;: Authors: Zhao J, Ma ST Abstract The present study aimed to investigate the role of long non-coding RNA (lncRNA) H19 in the development of osteosarcoma and to determine the underlying mechanism involved. A total of 40 patients with osteosarcoma were selected and the expression level of H19 in tumor tissue and adjacent healthy tissue was detected by reverse transcription‑quantitative polymerase chain reaction. Survival curves were plotted using the Kaplan‑Meier me...
Source: Molecular Medicine Reports - March 25, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Induction of Huh ‑7 cell apoptosis by HCV core proteins via CK1α‑p53‑Bid signaling pathway.
Induction of Huh‑7 cell apoptosis by HCV core proteins via CK1α‑p53‑Bid signaling pathway. Mol Med Rep. 2018 Apr 05;: Authors: Shen S, Li C, Dai M, Yan X Abstract Hepatitis C virus (HCV)‑infected liver cells sensitize host cells to tumor necrosis factor (TNF)‑related apoptosis‑inducing ligand (TRAIL)‑induced cell apoptosis; however, the precise mechanisms are unknown. In the present study, flow cytometry demonstrated that the Annexin V‑positive Huh‑7 cell number was higher in groups transfected with core proteins when compared with the pcDNA3.1 group. The mRNA and protein expression...
Source: Molecular Medicine Reports - April 6, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Dysregulation of PTEN caused by the underexpression of microRNA ‑130b is associated with the severity of lupus nephritis.
Dysregulation of PTEN caused by the underexpression of microRNA‑130b is associated with the severity of lupus nephritis. Mol Med Rep. 2018 Apr 03;: Authors: Wu S, Wang J, Li F Abstract There are several reports in the literature regarding microRNA (miR)‑130b. It has been reported that miR‑130b is involved in several diseases. The present study aimed to understand the association between the levels of miR‑130b and lupus nephritis in patients. A total of 61 blood samples were collected and the expression level of miR‑130b was determined. The online miRNA database was then searched using the 'se...
Source: Molecular Medicine Reports - April 6, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis.
Authors: Liu Y, Wang Y, Yao D, Cui D Abstract Epithelial ovarian cancer is one of the primary causes of gynecological cancer mortality. Increasing evidence has suggested that long non‑coding RNAs (lncRNAs) may serve a pivotal role in cancer development. To determine whether Lnc SRY‑box 4 (SOX4), an lncRNA, promotes the self‑renewal of liver tumor cells and contributes to the development of epithelial ovarian cancer, the present study investigated the expression of LncSOX4 in clinical epithelial ovarian cancer tissues and non‑cancer controls by reverse transcription‑quantitative polymerase chain reaction a...
Source: Molecular Medicine Reports - April 26, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Silencing activating transcription factor 2 promotes the anticancer activity of sorafenib in hepatocellular carcinoma cells.
Authors: Luo L, Cai L, Luo L, Tang Z, Meng X Abstract The present study aimed to investigate the anticancer effect of sorafenib combined with silencing of activating transcription factor 2 (ATF2) in hepatocellular carcinoma (HCC) cells and to assess the underlying molecular mechanisms. Huh‑7 HCC cell line was selected for the present study. Small interfering RNA (siRNA)‑ATF2 sequence was constructed to silence ATF2 expression. The experiment was divided into 6 groups: i) Control; ii) vector; iii) sorafenib (6.8 µM); iv) vector+sorafenib; v) siRNA‑ATF2; and vi) siRNA‑ATF2+sorafenib groups. Cell proli...
Source: Molecular Medicine Reports - April 26, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Analysis of NFKB2 ‑mediated regulation of mechanisms underlying the development of Hodgkin's lymphoma.
Analysis of NFKB2‑mediated regulation of mechanisms underlying the development of Hodgkin's lymphoma. Mol Med Rep. 2018 Apr 20;: Authors: Zhang Y, Tong L, Chen S, Wu W, Wang L Abstract Nuclear factor‑κB (NF‑κB) is widely involved in various lymphoid malignancies. However, its exact functional role and potential regulatory mechanisms in Hodgkin's lymphoma (HL) remains unclear. The present study aimed to investigate the regulatory mechanism of NF‑κB in HL by analysis of a gene expression profile that was obtained from HL cells with or without NF‑κB subunit 2 (NFKB2) knockdown. The GSE64234 ...
Source: Molecular Medicine Reports - April 26, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Napsin A is negatively associated with EMT ‑mediated EGFR‑TKI resistance in lung cancer cells.
Napsin A is negatively associated with EMT‑mediated EGFR‑TKI resistance in lung cancer cells. Mol Med Rep. 2018 May 25;: Authors: Zhou L, Lv X, Yang J, Zhu Y, Wang Z, Xu T Abstract Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‑TKI) have been used as a standard therapy for patients with lung cancer with EGFR‑activating mutations. Epithelial‑mesenchymal transition (EMT) has been reported to be associated with the development of EGFR‑TKI resistance, which limits the clinical efficacy of EGFR‑TKI. Therefore, investigating the resistance‑associated mechanism is required i...
Source: Molecular Medicine Reports - June 2, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome ‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy.
Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy. Mol Med Rep. 2018 Jun 14;: Authors: Qiao Y, Tian X, Men L, Li S, Chen Y, Xue M, Hu Y, Zhou P, Long G, Shi Y, Liu R, Liu Y, Qi Z, Cui Y, Shen Y Abstract Diabetic nephropathy (DN) is a serious complication of diabetes and can cause an increased mortality risk. It was previously reported that NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in the pathogenesis of diabetes. However, the...
Source: Molecular Medicine Reports - June 15, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

B7 ‑H1‑mediated immunosuppressive properties in human mesenchymal stem cells are mediated by STAT‑1 and not PI3K/Akt signaling.
B7‑H1‑mediated immunosuppressive properties in human mesenchymal stem cells are mediated by STAT‑1 and not PI3K/Akt signaling. Mol Med Rep. 2018 May 30;: Authors: Jang IK, Jung HJ, Noh OK, Lee DH, Lee KC, Park JE Abstract Mesenchymal stem cells (MSCs), derived from either bone marrow (BM) or Wharton's jelly (WJ), inhibit the proliferation of activated T cells, and interferon (IFN)‑γ serves an important role in this process. This process is B7‑homolog (H)1‑dependent during cell contact inhibition. However, the signaling pathway involved in B7‑H1 expression in MSCs remains largely undefine...
Source: Molecular Medicine Reports - June 15, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Knockdown of long noncoding RNA GHET1 inhibits cell ‑cycle progression and invasion of gastric cancer cells.
In this study, the expression of GHET1 was investigated in gastric cancer and it was determined whether GHET1 may potentially be used as a biomarker for the disease. The gastric cancer cell lines MGC‑803 and AGS were transfected with GHET1‑directed small interfering RNA (siRNA) and the changes in phenotype and cell‑cycle‑related molecules were assessed. The downregulation of GHET1 induced G0/G1‑phase arrest in gastric cancer cells and inhibited their proliferation, migration, and invasion. DNA synthesis and the expression of proliferating cell nuclear antigen (PCNA) decreased, which was consistent with the result...
Source: Molecular Medicine Reports - August 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

CXCL12 modulates the radiosensitivity of cervical cancer by regulating CD44.
In conclusion, the present data demonstrated that CXCL12 served an important role in the radioresistance of cervical cancer, suggestinh a novel therapeutic target. PMID: 30320394 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research