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Source: International Journal of Medical Sciences
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Total 14117 results found since Jan 2013.
Characterization of the Asian Phenotype - An Emerging Paradigm with Clinicopathological and Human Research Implications.
Conclusion: Interventions for various ailments that have traditionally ignored population differences have now entered the age of personalized, stratified or precision medicine requiring an individualized approach being adopted as a new standard of care. Factoring in Asian phenotypes is essential for the medical research community and the development of improved clinical practice guidelines across a continuum of disciplines that will ultimately translate to better human health round the world.
PMID: 28824295 [PubMed - in process]
Source: International Journal of Medical Sciences - August 23, 2017 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Major Pathophysiological Correlations of Rosacea: A Complete Clinical Appraisal.
Conclusion: Vasculature, chronic inflammatory responses, environmental triggers, food and chemicals ingested and microorganisms either alone or in combination are responsible for rosacea. Many promising drugs are under various phases of clinical trials and interestingly, probiotics could also possibly be used as one of the treatment option.
PMID: 26005373 [PubMed - as supplied by publisher]
Source: International Journal of Medical Sciences - June 3, 2015 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Odontomas and supernumerary teeth: is there a common origin?
Authors: Pippi R
Abstract
The aim of the present work is to analyze all scientific evidence to verify whether similarities supporting a unified explanation for odontomas and supernumerary teeth exist. A literature search was first conducted for epidemiologic studies indexed by PubMed, to verify their worldwide incidence. The analysis of the literature data shows some interesting similarities between odontomas and supernumerary teeth concerning their topographic distribution and pathologic manifestations. There is also some indication of common genetic and immuno-histochemical factors. Although from a nosological po...
Source: International Journal of Medical Sciences - June 3, 2015 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Salivary Secretory Disorders, Inducing Drugs, and Clinical Management.
CONCLUSION: At present, there are numerous frequently prescribed drugs whose unwanted effects include some kind of salivary disorder. In addition, the differing pathologic mechanisms, and the great variety of existing treatments hinder the clinical management of these patients. The authors have designed an algorithm to facilitate the decision making process when physicians, oral surgeons, or dentists face these salivary dysfunctions.
PMID: 26516310 [PubMed - in process]
Source: International Journal of Medical Sciences - November 1, 2015 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population.
Conclusion: Based on the evidence presented within the literature, the aforementioned biomarkers correlate significantly with metabolic syndrome and could provide a minimally-invasive means for early detection and specific treatment of these disorders. Further research is encouraged to determine the efficacy of applying these biomarkers to diagnosis and treatment in a clinical setting.
PMID: 26816492 [PubMed - as supplied by publisher]
Source: International Journal of Medical Sciences - January 28, 2016 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
GSK-3 β as a target for protection against transient cerebral ischemia.
GSK-3β as a target for protection against transient cerebral ischemia.
Int J Med Sci. 2017;14(4):333-339
Authors: Wang W, Li M, Wang Y, Wang Z, Zhang W, Guan F, Chen Q, Wang J
Abstract
Stroke remains the leading cause of death and disability worldwide. This fact highlights the need to search for potential drug targets that can reduce stroke-related brain damage. We showed recently that a glycogen synthase kinase-3β (GSK-3β) inhibitor attenuates tissue plasminogen activator-induced hemorrhagic transformation after permanent focal cerebral ischemia. Here, we examined whether GSK-3β inhibition mitigat...
Source: International Journal of Medical Sciences - May 30, 2017 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
High chloride channel accessory 1 expression predicts poor prognoses in patients with rectal cancer receiving chemoradiotherapy.
Conclusions: High expression of CLCA1 is significantly associated with poor therapeutic response and survival outcomes in rectal cancer patients with CCRT treatment before surgery. With the development of specific inhibitors, our findings indicate not only prognostic but also therapeutic potential of CLCA1 in rectal cancers.
PMID: 30123054 [PubMed - in process]
Source: International Journal of Medical Sciences - August 21, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Randomized, controlled clinical pilot study of venous leg ulcers treated with using two types of shockwave therapy.
Conclusion. There is no statistically significant difference between the use of radial and focused shockwave in the treatment of venous leg ulcers. Treatment of venous leg ulcers with shockwaves is more effective than the standard wound care.
PMID: 30275753 [PubMed - in process]
Source: International Journal of Medical Sciences - October 3, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Current status of endovascular treatment for dural arteriovenous fistulae in the anterior cranial fossa: A systematic literature review.
Authors: Xu K, Ji T, Li C, Yu J
Abstract
Anterior cranial fossa (ACF) dural arteriovenous fistulae (DAVFs) are rare, and a systematic review of the literature is lacking. Such a review is necessary, however, so a systematic PubMed search of related studies was performed. Twenty-four studies were identified, reporting on 48 patients, of whom 39 had definite age and sex information and 33 (84.6%, 33/39) were male. The afflicted patients were between 37 and 80 years old (mean 55.6). Among the 48 patients, 28 (58.3%, 28/48) primarily presented with intracranial hemorrhage, 47 (97.9%, 47/48) had feeding arteries from th...
Source: International Journal of Medical Sciences - February 14, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Clinical importance of the superficial temporal artery in neurovascular diseases: A PRISMA-compliant systematic review.
Authors: Hou K, Guo Y, Xu K, Yu J
Abstract
The superficial temporal artery (STA) plays a very important role in neurovascular diseases and procedures. However, until now, no comprehensive review of the role of STA in neurovascular diseases from a neurosurgical perspective has ever been published. To review research on the clinical importance of STA in neurovascular diseases, a literature search was performed using the PubMed database. Articles were screened for suitability and data relevance. This paper was organized following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline...
Source: International Journal of Medical Sciences - November 7, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
The addition of metformin to systemic anticancer therapy in advanced or metastatic cancers: a meta-analysis of randomized controlled trials.
In conclusion, this meta-analysis of randomized clinical trials indicates that the addition of metformin to systemic anticancer therapy has no clinical benefits in patients with advanced or metastatic cancer.
PMID: 33029097 [PubMed - in process]
Source: International Journal of Medical Sciences - October 9, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Clinical Outcomes of COVID-19 Patients with Pre-existing, Compromised Immune Systems: A Review of Case Reports.
Authors: Corse T, Dayan L, Kersten S, Battaglia F, Terlecky SR, Han Z
Abstract
In the ongoing COVID-19 pandemic, all COVID-19 patients are naïve patients as it is the first-time humans have been exposed to the SARS-CoV-2 virus. As with exposure to many viruses, individuals with pre-existing, compromised immune systems may be at increased risk of developing severe symptoms and/or dying because of (SARS-CoV-2) infection. To learn more about such individuals, we conducted a search and review of published reports on the clinical characteristics and outcomes of COVID-19 patients with pre-existing, compromised immune sy...
Source: International Journal of Medical Sciences - November 13, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Upregulation of peroxisome proliferator-activated receptor- α and the lipid metabolism pathway promotes carcinogenesis of ampullary cancer.
Upregulation of peroxisome proliferator-activated receptor-α and the lipid metabolism pathway promotes carcinogenesis of ampullary cancer.
Int J Med Sci. 2021;18(1):256-269
Authors: Wang CY, Chao YJ, Chen YL, Wang TW, Phan NN, Hsu HP, Shan YS, Lai MD
Abstract
Ampullary cancer is a rare periampullary cancer currently with no targeted therapeutic agent. It is important to develop a deeper understanding of the carcinogenesis of ampullary cancer. We attempted to explore the characteristics of ampullary cancer in our dataset and a public database, followed by a search for potential drugs. We used a bioinfo...
Source: International Journal of Medical Sciences - January 6, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Meta-analysis of the Diagnostic Performance of Circulating MicroRNAs for Pancreatic Cancer.
Conclusion: Circulating miRNAs exhibited satisfactory diagnostic performance for PC and even early-stage PC. The combination of circulating miRNAs and CA19-9 can further improve the diagnostic accuracy, providing a novel strategy for PC diagnosis.
PMID: 33437201 [PubMed - in process]
Source: International Journal of Medical Sciences - January 14, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Is liver involvement overestimated in COVID-19 patients? A meta-analysis.
Conclusion: The overall prevalence of liver injury and hypertransaminasemia in COVID-19 patients might be overestimated. Only a small fraction of COVID-19 patients have clinically significant liver injury. The prevalence of hypertransaminasemia was significantly higher in severe COVID-19 cases compare to non-severe cases. Hence, in severe COVID-19 patients, more attention should be paid to liver function tests.
PMID: 33526990 [PubMed - in process]
Source: International Journal of Medical Sciences - February 3, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
