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Delayed Reduction of Hepatitis B Viral Load and Dynamics of Adefovir-Resistant Variants during Adefovir plus Entecavir Combination Rescue Therapy.
CONCLUSION: Although ADV-resistant variants were suppressed, viral load reduction was delayed during ADV-ETV combination rescue therapy in patients with ADV-resistant HBV. The quantification of resistant variants by pyrosequencing may facilitate monitoring of antiviral therapy. PMID: 26005376 [PubMed - in process]
Source: International Journal of Medical Sciences - June 3, 2015 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma.
CONCLUSIONS: The expression of most HSPs was higher in tumour tissues than in non-tumour tissues. High BCLC staging scores, advanced cirrhosis and the overexpression of HSPA12A and HSP90B1 might be associated with poor survival from HCC, whereas high levels of HSPA4, HSPA5 and HSPA6 might be associated with earlier recurrence of HCC. PMID: 25798051 [PubMed - in process]
Source: International Journal of Medical Sciences - June 3, 2015 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Association between Interleukin-18 Polymorphisms and Hepatocellular Carcinoma Occurrence and Clinical Progression.
In conclusion, the IL-18 -137G/C polymorphism with a GC+CC genotype could be a factor that increases the risk of HCC. Furthermore, the correlation between the IL-18 -137G/C polymorphism and HCC-related HBV infection is a risk factor for vascular invasion and has a synergistic effect that can further enhance HCC prognosis. PMID: 27429592 [PubMed - in process]
Source: International Journal of Medical Sciences - July 20, 2016 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Correlation of Chitinase 3-Like 1 Single Nucleotide Polymorphisms with Hepatocellular Carcinoma in Taiwan.
In conclusion, our results indicate that patients with CHI3L1 rs880633 variant genotypes TC+CC are at a higher risk of HCC. CHI3L1 polymorphisms rs880633 or rs4950928 may be potential candidates for predicting poor HCC prognosis and clinical status. PMID: 28260989 [PubMed - in process]
Source: International Journal of Medical Sciences - March 7, 2017 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Increase of Soluble Programmed Cell Death Ligand 1 in Patients with Chronic Hepatitis C.
Conclusions: In this study, we first found that sPD-L1 was increased in patients with CHC. Our results indicate that the level of serum sPD-L1 might be associated with the progression of CHC and the generation of hepatocellular carcinoma. PMID: 28539815 [PubMed - in process]
Source: International Journal of Medical Sciences - May 26, 2017 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Interleukin-35 Level Is Elevated in Patients with Chronic Hepatitis B Virus Infection.
Conclusion: Our study identified that IL-35 may be a novel marker associated with HBV infection and hepatocytes injury. These data suggested the potential use of IL-35 in the HBV treatment. PMID: 29333103 [PubMed - in process]
Source: International Journal of Medical Sciences - January 17, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Efficacy and safety of nucleos(t)ide analogues to prevent hepatitis B virus mother-to-child transmission in pregnant women with high viremia: real life practice from China.
Conclusions: For pregnant women with HBV DNA greater than 5 log10IU/mL, LdT therapy was effective in reducing HBV MTCT. If serum HBV DNA was detectable at delivery, discontinuation of LdT immediately was found to be safe and rarely induced off-treatment hepatitis flare. PMID: 30008589 [PubMed - in process]
Source: International Journal of Medical Sciences - July 18, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo.
Authors: Yu HB, Jiang H, Cheng ST, Hu ZW, Ren JH, Chen J Abstract Sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD +)-dependent class III histone deacetylase. We have reported that HBx (hepatitis B virus X protein)-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis. However, the potential anti-HBV effect of AGK2, a selective inhibitor of SIRT2, has not been reported. Here, the role of AGK2 on HBV replication was examined in the HepAD38 and HepG2-NTCP cell lines. The HBV genome was stably integrated in HepAD38 cell line which expresses HBV under the control of tetracycline. The HepG2-NTCP ...
Source: International Journal of Medical Sciences - October 3, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Switching Lamivudine with Adefovir Dipivoxil Combination Therapy to Entecavir Monotherapy Provides Better Viral Suppression and Kidney Safety.
Conclusion: Switching to ETV monotherapy can decrease HBV-DNA levels, reduce the genetic mutation rate, and prevent renal damage caused by LAM and ADV combination therapy in patients with CHB and compensated liver cirrhosis. Patients receiving LAM and ADV combination therapy de novo should be switched to ETV monotherapy immediately. PMID: 30662324 [PubMed - in process]
Source: International Journal of Medical Sciences - January 22, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Glucocorticoid Regulates NLRP3 in Acute-On-Chronic Hepatitis B Liver Failure.
In conclusion, NLRP3 increased in patients with ACHBLF. Glucocorticoid could downregulate the expression of NLRP3 in surviving patients with ACHBLF. PMID: 30911280 [PubMed - in process]
Source: International Journal of Medical Sciences - March 27, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Dynamic Differences Of Red Cell Distribution Width Levels Contribute To The Differential Diagnosis Of Hepatitis B Virus-related Chronic Liver Diseases: A Case-control Study.
Conclusions: RDW is significantly increased in HBeAg+ CHB patients and patients with HBV-related hepatocirrhosis and could reflect their severity. RDW could help to distinguish hepatocirrhosis from CHB patients and inactive HBV carriers. PMID: 31217740 [PubMed - in process]
Source: International Journal of Medical Sciences - June 22, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutations.
Conclusions: SNP rs7717457 is associated with the selection of HBV BCP double mutations, providing an important clue to understanding the mechanisms of oncogenesis of HBV BCP double mutations. PMID: 31341412 [PubMed - in process]
Source: International Journal of Medical Sciences - July 26, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus.
Authors: Win NN, Kanda T, Ogawa M, Nakamoto S, Haga Y, Sasaki R, Nakamura M, Wu S, Matsumoto N, Matsuoka S, Kato N, Shirasawa H, Yokosuka O, Okamoto H, Moriyama M Abstract Hepatitis A virus (HAV) infection is a major cause of acute hepatitis including acute liver failure. Hepatitis B infection (HBV) occurs worldwide, with the highest rates in Asian and African countries, and there are several reports that HAV infection may have a more severe clinical course in patients with chronic HBV infection. We previously demonstrated that Japanese miso extracts have inhibitory effects on HAV replication. In the present study,...
Source: International Journal of Medical Sciences - November 7, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Pregnancy Outcome of Women with Chronic Hepatitis B who Discontinued Antiviral Treatment before or in the Early Pregnancy.
Conclusion: ALT flares were common in mothers who discontinued antiviral therapy. Thus, these pregnant women should be monitored closely. Cessation of treatment was not recommended although no hepatic failure was observed. Larger studies are needed to evaluate the safety of discontinuation before pregnancy. PMID: 32038100 [PubMed - in process]
Source: International Journal of Medical Sciences - February 12, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

HBV DNA and HBsAg: Early Prediction of Response to Peginterferon α-2a in HBeAg-Negative Chronic Hepatitis B.
Conclusion: Early on-treatment quantification of HBV DNA and HBsAg in patients with HBeAg-negative CHB treated with peg-IFN α-2a may help identify those likely to be cured by this method and optimize therapy strategies. PMID: 32132873 [PubMed - in process]
Source: International Journal of Medical Sciences - March 8, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

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