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Source: Allergy, Asthma and Clinical Immunology

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Total 783 results found since Jan 2013.

Cytokine profiles in nasal fluid of patients with seasonal or persistent allergic rhinitis
Conclusions: Elevated levels of proinflammatory cytokines were seen in both disease entities. They were, however, more pronounced in SAR, indicating a higher degree of inflammation. This study suggests a downregulation of T H 1 and T reg -lymphocytes and an upregulation of T H 17 in SAR. Moreover, the results display a prominent role of eosinophils and mast cells in AR. The observed distinct cytokine profiles in nasal secretion may prove useful as a diagnostic tool helping to match patients to antibody therapies.
Source: Allergy, Asthma and Clinical Immunology - September 22, 2015 Category: Allergy & Immunology Authors: Katrin KönigChristine KlemensKatharina EderMarion San NicolóSven BeckerMatthias KramerMoritz Gröger Source Type: research

Health-related quality of life in patients with primary immunodeficiency disease
Primary immunodeficiency disease (PIDD) with hypogammaglobulinemia is characterized by recurrent and severe bacterial infections and IgG replacement is the standard of care in many of these patients. Health-related quality of life (HRQOL) is becoming increasingly recognized as a factor that affects patient well-being and treatment preferences. In an effort to better understand what factors affect HRQOL in patients with PIDD, we reviewed the published literature that used standardized instruments for the measurement of HRQOL. We investigated HRQOL in PIDD patients compared with normal controls and patients with other chroni...
Source: Allergy, Asthma and Clinical Immunology - September 29, 2015 Category: Allergy & Immunology Authors: Fonda JiangTroy TorgersonAndrew Ayars Source Type: research

Tropomyosin, the major tropical oyster Crassostrea belcheri allergen and effect of cooking on its allergenicity
Conclusions: Cooked extracts produce lower IgE-binding than raw extract, which suggest that thermal treatment can be used as a tool in attempting to reduce oyster allergenicity by reducing the number of IgE-reactive bands. The degree of allergenicity of this oyster was demonstrated in the order raw > boiled > fried ≈ roasted. A heat-resistent 37 kDa protein, corresponding to tropomyosin, was identified as the major allergen of this tropical oyster.
Source: Allergy, Asthma and Clinical Immunology - October 26, 2015 Category: Allergy & Immunology Authors: Zailatul YadzirRosmilah MisnanFaizal BakhtiarNoormalin AbdullahShahnaz Murad Source Type: research

Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration
We report the first case of generalized urticarial reaction and facial angioedema after therapy with denosumab. A subcutaneous desensitization protocol was successfully completed in this patient. Rapid desensitization is a promising method for the delivery of denosumab after a hypersensitivity reaction, and should be considered in osteoporosis treatment when no acceptable therapeutic alternatives are available.
Source: Allergy, Asthma and Clinical Immunology - October 26, 2015 Category: Allergy & Immunology Authors: D. Gutiérrez-FernándezMaría-Jesús CruzA. Foncubierta-FernándezA. Moreno-AncilloM. Fernández-AnguitaF. Medina-VaroJ. Andres-García Source Type: research

Allergen immunotherapy in pregnancy
Conclusions: Based on these data, the continuation of AIT during pregnancy appears safe. Furthermore, the few data available suggest that the initiation of AIT during pregnancy might also be safe, however, more data is required for a definitive conclusion. Lastly, available studies do not show a convincing reduction in the development of atopy in offspring from the administration of AIT during pregnancy.
Source: Allergy, Asthma and Clinical Immunology - November 10, 2015 Category: Allergy & Immunology Authors: Paul OykhmanHarold KimAnne Ellis Source Type: research

T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients
Conclusion: We showed a reduction of GATA3 and RORc mRNA, low Treg-related cytokines and elevated Th2 cytokine levels in eosinophilic chronic rhinosinusitis, whereas we demonstrated the upregulation of Treg cells and increases of Th1 and Th17 cytokines in non-eosinophilic chronic rhinosinusitis in the Japanese population. The different mRNA expression profiles of Treg and Th1/Th2/Th17 signature transcription factors and cytokines between eosinophilic chronic rhinosinusitis and non-eosinophilic chronic rhinosinusitis suggests heterogeneity in the pathogenesis of chronic rhinosinusitis with nasal polyps.
Source: Allergy, Asthma and Clinical Immunology - November 19, 2015 Category: Allergy & Immunology Authors: Shintaro BabaRyoji KagoyaKenji KondoMaho SuzukawaKen OhtaTatsuya Yamasoba Source Type: research

The gender, age and risk factor distribution differs in self-reported allergic and non-allergic rhinitis: a cross-sectional population-based study
This study aimed at estimating the prevalence and at comparing the risk factor distribution of AR and NAR in a general population sample aged 20–84 years in Italy. Methods: A questionnaire on respiratory symptoms and risk factors was administered to random samples of the Italian population aged 20–44 (n = 10,494) 45–64 (n = 2167) and 65–84 (n = 1030) in the frame of the Gene Environment Interactions in Respiratory Diseases (GEIRD) study. Current AR and NAR were defined according to the self-reported presence of nasal allergies or of nasal symptoms without a cold or the flu. Results: NAR showed a significant ...
Source: Allergy, Asthma and Clinical Immunology - December 4, 2015 Category: Allergy & Immunology Authors: Lucia CazzolettiMarcello FerrariMario OlivieriGiuseppe VerlatoLeonardo AntonicelliRoberto BonoLucio CasaliIsa CerveriPierpaolo MarchettiPietro PirinaAndrea RossiSimona VillaniRoberto de Marco Source Type: research

TNF up-regulates Pentraxin3 expression in human airway smooth muscle cells via JNK and ERK1/2 MAPK pathways
Conclusions: Our data suggest that TNF induced PTX3 in HASMC at least via a transcriptional mechanism that involved MAPK (JNK and ERK1/2), NF-κβ and AP1 pathways. These results rise the possibility that HASMC derived PTX3 may participate in immune regulation in the airways.
Source: Allergy, Asthma and Clinical Immunology - December 7, 2015 Category: Allergy & Immunology Authors: Jingbo ZhangLatifa KoussihLianyu ShanAndrew HalaykoBen-Kuen ChenAbdelilah Gounni Source Type: research

Powder milk: a user-friendly and safe product for heated-milk food challenge?
Conclusion: Challenge with instant skim milk powder could be a safe, convenient and easily standardizable alternative to home baked food for heated milk challenge. Further controlled studies are needed before this can be implemented to practice.
Source: Allergy, Asthma and Clinical Immunology - December 23, 2015 Category: Allergy & Immunology Authors: Sabrine CherkaouiPhilippe BéginLouis ParadisJean ParadisAnne Roches Source Type: research

Sensitization to common aeroallergens in a population of young adults in a sub-Saharan Africa setting: a cross-sectional study
Conclusion: A significant proportion of young adults are sensitized to common aeroallergens. Dust mites and cockroach should be included in the panel of aeroallergens in Cameroon.
Source: Allergy, Asthma and Clinical Immunology - January 4, 2016 Category: Allergy & Immunology Authors: Bertrand Mbatchou NgahaneDiane NoahMalea Nganda MottoYacouba Mapoure NjankouoLouis Njock Source Type: research

Association between allergic rhinitis and metabolic conditions: a nationwide survey in Korea
Conclusion: In this population, AR was diagnosed less frequently in subjects with metabolic conditions. Well-designed prospective studies allowing for medical service utilization and collaborative basic research are warranted to elucidate the mechanism responsible for this inverse relationship.
Source: Allergy, Asthma and Clinical Immunology - January 22, 2016 Category: Allergy & Immunology Authors: In HwangYong LeeHong AhnSang Lee Source Type: research

The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness
Human African trypanosomiasis due to Trypanosoma brucei rhodesiense is invariably fatal if untreated with up to 12.3 million people at a risk of developing the disease in Sub-Saharan Africa. The disease is characterized by a wide spectrum of clinical presentation coupled with differences in disease progression and severity. While the factors determining this varied response have not been clearly characterized, inflammatory cytokines have been partially implicated as key players. In this review, we consolidate available literature on the role of specific cytokines in the pathogenesis of T. b. rhodesiense sleeping sickness a...
Source: Allergy, Asthma and Clinical Immunology - January 22, 2016 Category: Allergy & Immunology Authors: Charles KatoEnock MatovuClaire. MugasaAnn NantezaVincent Alibu Source Type: research

Anaphylaxis following a transvaginal ultrasound
Polyethylene glycol is a ubiquitous, water-soluble, organic compound found in a wide variety of commercially available products. While generally a benign substance, in rare instances, it can induce hypersensitivity reactions. Herein, we describe a case of anaphylaxis to polyethylene glycol-containing lubricating gel used for a transvaginal ultrasound. This case highlights the importance of early recognition of a rare cause of anaphylaxis that may occur in the health-care setting. It is of particular importance given the widespread use of similar lubricating materials in multiple practice settings for the use of internal ex...
Source: Allergy, Asthma and Clinical Immunology - January 22, 2016 Category: Allergy & Immunology Authors: Baruch JakubovicCorey SaperiaGordon Sussman Source Type: research

Association between allergic rhinitis and metabolic conditions: a nationwide survey in Korea
Accumulating evidence indicates a strong correlation between allergic disease and cardiovascular risks. In spite of this, the data concerning the association between allergic rhinitis (AR) and cardiovascular r...
Source: Allergy, Asthma and Clinical Immunology - January 22, 2016 Category: Allergy & Immunology Authors: In Cheol Hwang, Yong Joo Lee, Hong Yup Ahn and Sang Min Lee Source Type: research

Anaphylaxis following a transvaginal ultrasound
Polyethylene glycol is a ubiquitous, water-soluble, organic compound found in a wide variety of commercially available products. While generally a benign substance, in rare instances, it can induce hypersensit...
Source: Allergy, Asthma and Clinical Immunology - January 22, 2016 Category: Allergy & Immunology Authors: Baruch D. Jakubovic, Corey Saperia and Gordon L. Sussman Source Type: research