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Source: Allergy, Asthma and Clinical Immunology

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Total 783 results found since Jan 2013.

The effect of vitamin C on bronchoconstriction and respiratory symptoms caused by exercise: a review and statistical analysis
Physical activity increases oxidative stress and therefore the antioxidant effects of vitamin C administration might become evident in people undertaking vigorous exercise. Vitamin C is involved in the metabolism of histamine, prostaglandins, and cysteinyl leukotrienes, all of which appear to be mediators in the pathogenesis of exercise-induced bronchoconstriction (EIB). Three studies assessing the effect of vitamin C on patients with EIB were subjected to a meta-analysis and revealed that vitamin C reduced postexercise FEV1 decline by 48% (95% CI: 33% to 64%). The correlation between postexercise FEV1 decline and respirat...
Source: Allergy, Asthma and Clinical Immunology - November 27, 2014 Category: Allergy & Immunology Authors: Harri Hemilä Source Type: research

Canadian hereditary angioedema guideline
The objective of this guideline is to provide graded recommendations for the management of patients in Canada with HAE. This includes the treatment of attacks, short-term prophylaxis, long-term prophylaxis, and recommendations for self-administration, individualized therapy, quality of life, and comprehensive care. It is anticipated that by providing this guideline to caregivers, policy makers, patients and their advocates, that there will be an improved understanding of the current recommendations regarding management of HAE and the factors that need to be considered when choosing therapies and treatment plans for individ...
Source: Allergy, Asthma and Clinical Immunology - October 22, 2014 Category: Allergy & Immunology Authors: Stephen BetschelJacquie BadiouKaren BinkleyJacques HébertAmin KananiPaul KeithGina LacuestaBill YangEmel Aygören-PürsünJonathan BernsteinKonrad BorkTeresa CaballeroMarco CicardiTimothy CraigHenriette FarkasHilary LonghurstBruce ZurawHenrik BoysenRozit Source Type: research

Measuring eosinophiluria, urinary eosinophil cationic protein and urinary interleukin-5 in patients with Lupus Nephritis
Background: Urine is increasingly becoming an attractive biological fluid in clinical practice due to being an easily obtained, non-invasive sampling method, containing proteins and peptides. The aim of this study was to investigate eosinophiluria, urinary eosinophil cationic protein (uECP) and urinary IL-5 (uIL-5) in patients with Lupus Nephritis. Methods: Seventy-four patients with SLE—20 with clinical and laboratory evidence of lupus nephritis (LN group) and 54 without evidence of renal involvement (non-LN group)—were analyzed regarding eosinophiluria, uECP and uIL-5. Eosinophiluria was observed by Hansel's stain, E...
Source: Allergy, Asthma and Clinical Immunology - December 12, 2014 Category: Allergy & Immunology Authors: Tereza BritoMaria VilarJosé AlmeidaAna FariaSarah MedeirosMaria MedeirosEdna SilvaVanessa SilvaLuanda SouzaLuisa ArrudaTatiana CostaGeraldo JuniorAntonio OliveiraValéria Sales Source Type: research

Examination of genetic variants involved in generation and biodisposition of kinins in patients with angioedema
Conclusions: In addition to related diseases and medications causing AE, certain genetic variants encoding proteins involved in bradykinin generation and/or catabolism pathways may be involved in the pathogenesis of AE.
Source: Allergy, Asthma and Clinical Immunology - December 12, 2014 Category: Allergy & Immunology Authors: Jonathan LevyGeorges-Etienne RivardEric WagnerDon BeezholdNoam BerlinLi FanZhao ZhangGordon Sussman Source Type: research

Successful use of daily intravenous infusion of C1 esterase inhibitor concentrate in the treatment of a hereditary angioedema patient with ascites, hypovolemic shock, sepsis, renal and respiratory failure
We report the first case of a patient with HAE who experienced an abdominal attack precipitated by a retroperitoneal bleed while being converted from warfarin to heparin in preparation for surgery. Subsequently, the patient had a protracted course in hospital with other complications, which included hypovolemic shock, ascites, severe sepsis from nosocomial pneumonia, renal and respiratory failure. Despite intensive interventions, the patient remained in a critical state for months; however, after a trial of daily intravenous infusion of pdC1-INH concentrate (Berinert®, CSL Behring GmbH, Marburg, Germany), clinical status ...
Source: Allergy, Asthma and Clinical Immunology - December 11, 2014 Category: Allergy & Immunology Authors: Hoang PhamStephanie SantucciWilliam Yang Source Type: research

Initiation of immunoglobulin therapy by subcutaneous administration in immunodeficiency patients naive to replacement therapy
Conclusions: Initiation of SCIG by doubling the maintenance dose over 2 weeks may be a well-tolerated and effective option for patients with antibody deficiencies requiring Ig replacement, especially among older patients.
Source: Allergy, Asthma and Clinical Immunology - December 6, 2014 Category: Allergy & Immunology Authors: Alan KoterbaMark Stein Source Type: research

Asian sand dust aggregate causes atopic dermatitis-like symptoms in Nc/Nga mice
Background: Asian sand dust (ASD) originates from the arid and semiarid areas of China, and epidemiologic studies have shown that ASD exposure is associated with various allergic and respiratory symptoms. However, few studies have been performed to assess the relationship between skin inflammation and ASD exposure. Methods: Twelve-week-old NC/Nga mice were divided into 6 groups (n?=?8 for each group): hydrophilic petrolatum only (control); hydrophilic petrolatum plus ASD (ASD); hydrophilic petrolatum and heat inactivated-ASD (H-ASD); Dermatophagoides farinae extract (Df); Df and ASD (Df?+?ASD), and; Df and H-ASD (Df?+?H-AS...
Source: Allergy, Asthma and Clinical Immunology - January 23, 2015 Category: Allergy & Immunology Authors: Sayaka TakeshitaTakahiro TokunagaYoshiko TanabeTadao ArinamiTakamichi IchinoseEmiko Noguchi Source Type: research

Clinical validation of controlled grass pollen challenge in the Environmental Exposure Unit (EEU)
Conclusions: This study provides clinical validation of the ability to generate allergic rhinoconjunctivitis symptoms amongst grass-allergic individuals in the EEU.
Source: Allergy, Asthma and Clinical Immunology - January 27, 2015 Category: Allergy & Immunology Authors: Anne EllisLisa SteacyBarnaby HobsbawnCaroline ConwayTerry Walker Source Type: research

Insights and advances in chronic urticaria: a Canadian perspective
In the past few years there have been significant advances which have changed the face of chronic urticaria. In this review, we aim to update physicians about clinically relevant advances in the classification, diagnosis and management of chronic urticaria that have occurred in recent years. These include clarification of the terminology used to describe and classify urticaria. We also detail the development and validation of instruments to assess urticaria and understand the impairment on quality-of-life and the morbidity caused by this disease. Additionally, the approach to management of chronic urticaria now focuses on ...
Source: Allergy, Asthma and Clinical Immunology - February 11, 2015 Category: Allergy & Immunology Authors: Gordon SussmanJacques HébertWayne GulliverCharles LyndeSusan WasermanAmin KananiMoshe Ben-ShoshanSpencer HoremansCarly BarronStephen BetschelWilliam YangJan DutzNeil ShearGina LacuestaPeter VadasKenneth KobayashiHermenio LimaF Simons Source Type: research

Evaluation of patients¿ expectations and benefits in the treatment of allergic rhinitis with a new tool: the patient benefit index ¿ the benefica study
Background: Symptoms of allergic rhinitis (AR) have a detrimental effect on quality of life. The AR-Patient Benefit Index (AR-PBI), a specific self-assessment tool has been developed to assess treatment-related benefit in two separate sections: the Patient Needs Questionnaire (PNQ) which explores the patient’s expectations before treatment and the Patient Benefit Questionnaire (PBQ) which evaluates treatment benefit. For the PNQ, three dimensions summarized patients’ expectations: symptoms, social life and emotional state, thus covering a larger field than symptomatic relief. The aim of the study was to validate the Fr...
Source: Allergy, Asthma and Clinical Immunology - February 26, 2015 Category: Allergy & Immunology Authors: Pascal DemolyMichel AubierFrédéric de BlayFrançois WesselPierre ClersonPascal Maigret Source Type: research

The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies
TRPA1 has been proposed to be associated with diverse sensory allergic reactions, including thermal (cold) nociception, hearing and allergic inflammatory conditions. Some naturally occurring compounds are known to activate TRPA1 by forming a Michael addition product with a cysteine residue of TRPA1 through covalent protein modification and, in consequence, to cause allergic reactions. The anti-allergic property of TRPA1 agonists may be due to the activation and subsequent desensitization of TRPA1 expressed in sensory neurons. In this review, naturally occurring TRPA1 antagonists, such as camphor, 1,8-cineole, menthol, born...
Source: Allergy, Asthma and Clinical Immunology - March 16, 2015 Category: Allergy & Immunology Authors: Satoru MiharaTakayuki Shibamoto Source Type: research

Central obesity and other factors associated with uncontrolled asthma in women
Conclusions: Asthma remains uncontrolled in women despite treatment, and central obesity seems to have a negative influence on the control of the disease. We believe that women should be studied as a separate group and suggest prospective studies with assessment of fat distribution and biomarkers, controlling for possible comorbidities associated with asthma control.
Source: Allergy, Asthma and Clinical Immunology - March 31, 2015 Category: Allergy & Immunology Authors: Albertina CapeloVania de FonsecaMaria PeixotoSonia de CarvalhoLarissa Guerino Source Type: research

Retraction Note: Meeting Abstract: A post-hoc qualitative analysis of real time heads-up pollen counting versus traditional microscopy counting in the environmental exposure unit (EEU)
No description available
Source: Allergy, Asthma and Clinical Immunology - April 17, 2015 Category: Allergy & Immunology Authors: Lisa SteacyTerry WalkerBarnaby HobsbawnJenny ThieleAnne Ellis Source Type: research

The Allergic Rhinitis – Clinical Investigator Collaborative (AR-CIC): nasal allergen challenge protocol optimization for studying AR pathophysiology and evaluating novel therapies
Background: The Nasal Allergen Challenge (NAC) model allows the study of Allergic Rhinitis (AR) pathophysiology and the proof of concept of novel therapies. The Allergic Rhinitis – Clinical Investigator Collaborative (AR-CIC) aims to optimize the protocol, ensuring reliability and repeatability of symptoms to better evaluate the therapies under investigation. Methods: 20 AR participants were challenged, with 4-fold increments of their respective allergens every 15minutes, to determine the qualifying allergen concentration (QAC) at which the Total Nasal Symptom Score (TNSS) of ≥10/12 OR a Peak Nasal Inspiratory Flow (PN...
Source: Allergy, Asthma and Clinical Immunology - April 24, 2015 Category: Allergy & Immunology Authors: Anne EllisMena SolimanLisa SteacyMarie-Ève BoulayLouis-Philippe BouletPaul KeithHarissios VliagoftisSusan WasermanHelen Neighbour Source Type: research

Retrospective case note review of chronic spontaneous urticaria outcomes and adverse effects in patients treated with omalizumab or ciclosporin in UK secondary care
Background: Omalizumab is approved in the UK as add-on treatment for chronic spontaneous urticaria (CSU) in patients with inadequate response to H 1 -antihistamines. Ciclosporin is an established but unlicensed 3rd line option for CSU. Two parallel retrospective observational studies were conducted to describe outcomes of treatment and adverse events with omalizumab or ciclosporin for CSU treatment. Methods: Data from UK specialist centres prescribing omalizumab (five centres) or ciclosporin (three centres) in CSU patients were collected from hospital records by clinical staff and pooled for analysis...
Source: Allergy, Asthma and Clinical Immunology - July 21, 2015 Category: Allergy & Immunology Authors: Sinisa SavicAlexander MarslandDavid McKayMichael Ardern-JonesTabi LeslieOlivier SomenziLaura BaldockClive Grattan Source Type: research