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Total 981 results found since Jan 2013.

Molecules, Vol. 27, Pages 6109: Zika Virus Inhibitors Based on a 1,3-Disubstituted 1H-Pyrazolo3,4-dpyrimidine-amine Scaffold
ng Chen To search for Zika virus (ZIKV) antivirals, we have further explored previously reported 7H-pyrrolo[2,3-d]pyrimidines by examining an alternative substitution pattern of their central scaffold, leading to compound 5 with low micromolar antiviral activity. To circumvent the synthetic difficulties associated with compound 5, we have exploited a 1H-pyrazolo[3,4-d]pyrimidine scaffold and performed structure-activity relationship studies on its peripheral rings A and B. While ring B is less sensitive to structural modifications, an electron-withdrawing group at the para position of ring A is preferred for enhanced a...
Source: Molecules - September 19, 2022 Category: Chemistry Authors: Eunkyung Jung Ruben Soto-Acosta Robert J. Geraghty Liqiang Chen Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6071: Functionalized 10-Membered Aza- and Oxaenediynes through the Nicholas Reaction
rina A. Balova The scope and limitations of the Nicholas-type cyclization for the synthesis of 10-membered benzothiophene-fused heterocyclic enediynes with different functionalities were investigated. Although the Nicholas cyclization through oxygen could be carried out in the presence of an ester group, the final oxaenediyne was unstable under storage. Among the N-type Nicholas reactions, cyclization via an arenesulfonamide functional group followed by mild Co-deprotection was found to be the most promising, yielding 10-membered azaendiynes in high overall yields. By contrast, the Nicholas cyclization through the acyl...
Source: Molecules - September 17, 2022 Category: Chemistry Authors: Natalia A. Danilkina Ekaterina A. Khmelevskaya Anna G. Lyapunova Alexander S. D ’yachenko Alexander S. Bunev Rovshan E. Gasanov Maxim A. Gureev Irina A. Balova Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6032: Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug & mdash;A Review
Molecules, Vol. 27, Pages 6032: Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review Molecules doi: 10.3390/molecules27186032 Authors: Jun-O Jin Dhananjay Yadav Kajal Madhwani Nidhi Puranik Vishal Chavda Minseok Song Marine natural products are a discerning arena to search for the future generation of medications to treat a spectrum of ailments. Meanwhile, cancer is becoming more ubiquitous over the world, and the likelihood of dying from it is rising. Surgery, radiation, and chemotherapy are the mainstays of cancer treatment worldwide, but their extensive side ef...
Source: Molecules - September 16, 2022 Category: Chemistry Authors: Jun-O Jin Dhananjay Yadav Kajal Madhwani Nidhi Puranik Vishal Chavda Minseok Song Tags: Review Source Type: research

Molecules, Vol. 27, Pages 6052: Determination of Apoptotic Mechanism of Action of Tetrabromobisphenol A and Tetrabromobisphenol S in Human Peripheral Blood Mononuclear Cells: A Comparative Study
Conclusions: It was found that TBBPS, and more strongly TBBPA, triggered apoptosis in human PBMCs. Generally, the mitochondrial pathway was involved in the apoptotic action of tested compounds; nevertheless, TBBPS more strongly than TBBPA caused intrinsic pathway activation.
Source: Molecules - September 16, 2022 Category: Chemistry Authors: Anna Bara ńska Bo żena Bukowska Jaromir Micha łowicz Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6008: Brassica Genus Seeds: A Review on Phytochemical Screening and Pharmacological Properties
Bouajila Traditionally, Brassica species are widely used in traditional medicine, human food, and animal feed. Recently, special attention has been dedicated to Brassica seeds as source of health-promoting phytochemicals. This review provides a summary of recent research on the Brassica seed phytochemistry, bioactivity, dietary importance, and toxicity by screening the major online scientific database sources and papers published in recent decades by Elsevier, Springer, and John Wiley. The search was conducted covering the period from January 1964 to July 2022. Phytochemically, polyphenols, glucosinolates, and their de...
Source: Molecules - September 15, 2022 Category: Chemistry Authors: Ayadi Debouba Rahmani Bouajila Tags: Review Source Type: research

Molecules, Vol. 27, Pages 5959: Impact of Different Storage Regimes on the Levels of Physicochemical Characteristics, Especially Free Acidity in Talh (Acacia gerrardii Benth.) Honey
This study investigates how storage conditions (temperature and duration) may affect the physicochemical parameters, especially free acidity (FA), of Talh honey originating from Acacia gerrardii that have naturally high FA levels. Fresh Talh honey samples were kept at 0, 25, 35, and 45 °C, and analyzed monthly over a period of eight months. The Talh honey was monofloral with 69% A. gerrardii pollen content. The free acidity (FA) of freshly harvested Talh honey samples was higher (93 ± 0.3 meq/kg) than that of standard limits (≤50 meq/kg) and remained stable at 0 °C througho...
Source: Molecules - September 13, 2022 Category: Chemistry Authors: Hael S. A. Raweh Ahmed Yacine Badjah-Hadj-Ahmed Javaid Iqbal Abdulaziz S. Alqarni Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5841: A Carabrane-Type Sesquiterpenolide Carabrone from Carpesium cernuum Inhibits SW1990 Pancreatic Cancer Cells by Inducing Ferroptosis
n-Li Yang Pancreatic cancer has an extremely poor prognosis, and the clinical drugs for the treatment of pancreatic cancer are usually multi-drug combinations. Therefore, it is necessary to search for and find specific new bioactive agents against pancreatic cancer. Carabrone is a carabrane-type sesquiterpenolide extracted from Carpesium cernuum L., and this natural compound has been reported to be a potential anti-tumor agent. However, there are few reports on the function of carabrone related to anti-tumor activity in pancreatic cancer. Herein, cell experiments indicated that carabrone had anti-proliferation inhibiti...
Source: Molecules - September 9, 2022 Category: Chemistry Authors: Yi-Dan Zheng Ying Zhang Jun-Yi Ma Chun-Yan Sang Jun-Li Yang Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5809: An Investigation of the Anti-Depressive Properties of Phenylpropanoids and Flavonoids in Hemerocallis citrina Baroni
an Ying Jia The World Health Organization predicts that over the next several years, depression will become the most important mental health issue globally. Growing evidence shows that the flower buds of Hemerocallis citrina Baroni (H. citrina) possess antidepressant properties. In the search for new anti-depression drugs, a total of 15 phenylpropanoids and 22 flavonoids were isolated and identified based on spectral data (1D and 2D NMR, HR-ESI-MS, UV) from H. citrina. Among them, compound 8 was a novel compound, while compounds 1–4, 6, 9, 10, 15, 17, 24–26, 28, and 37 were isolated for th...
Source: Molecules - September 8, 2022 Category: Chemistry Authors: Tiancheng Ma Yu Sun Lida Wang Jinyu Wang Bo Wu Tingxu Yan Ying Jia Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5784: Terpenoids from the Seeds of Toona sinensis and Their Ability to Attenuate High Glucose-Induced Oxidative Stress and Inflammation in Rat Glomerular Mesangial Cells
g Wanzhong Li Toona sinensis (A. Juss.) Roem is an edible medicinal plant that belongs to the genus Toona within the Meliaceae family. It has been confirmed to display a wide variety of biological activities. During our continuous search for active constituents from the seeds of T. sinensis, two new acyclic diterpenoids (1–2), together with five known limonoid-type triterpenoids (3–7), five known apotirucallane-type triterpenoids (8–12), and three known cycloartane-type triterpenoids (13–15), were isolated and characterized. Their structures were identified base...
Source: Molecules - September 7, 2022 Category: Chemistry Authors: Ying Chen Hong Gao Xiaoxiao Liu Jinyi Zhou Yijin Jiang Feng Wang Rongshen Wang Wanzhong Li Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5787: Chemical Composition Assessment of Structural Parts (Seeds, Peel, Pulp) of Physalis alkekengi L. Fruits
Skrovankova Mlcek In recent years there has been an extensive search for nature-based products with functional potential. All structural parts of Physalis alkekengi (bladder cherry), including fruits, pulp, and less-explored parts, such as seeds and peel, can be considered sources of functional macro- and micronutrients, bioactive compounds, such as vitamins, minerals, polyphenols, and polyunsaturated fatty acids, and dietetic fiber. The chemical composition of all fruit structural parts (seeds, peel, and pulp) of two phenotypes of P. alkekengi were studied. The seeds were found to be a rich source of oil, yieldin...
Source: Molecules - September 7, 2022 Category: Chemistry Authors: Popova Petkova Mazova Ivanova Petkova Stoyanova Stoyanova Ercisli Okcu Skrovankova Mlcek Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5745: Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects
de-Tovar Autologous bone is the gold standard in regeneration processes. However, there is an endless search for alternative materials in bone regeneration. Xenografts can act as bone substitutes given the difficulty of obtaining bone tissue from patients and before the limitations in the availability of homologous tissue donors. Bone neoformation was studied in critical-size defects created in the parietal bone of 40 adult male Wistar rats, implanted with xenografts composed of particulate bovine hydroxyapatite (HA) and with blocks of bovine hydroxyapatite (HA) and Collagen, which introduces crystallinity to the mater...
Source: Molecules - September 6, 2022 Category: Chemistry Authors: Carlos Humberto Valencia-Llano Diego L ópez-Tenorio Marcela Saavedra Paula A. Zapata Carlos David Grande-Tovar Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5732: New Chemicals Suppressing SARS-CoV-2 Replication in Cell Culture
Vladimir Sulimov Candidates to being inhibitors of the main protease (Mpro) of SARS-CoV-2 were selected from the database of Voronezh State University using molecular modeling. The database contained approximately 19,000 compounds represented by more than 41,000 ligand conformers. These ligands were docked into Mpro using the SOL docking program. For one thousand ligands with best values of the SOL score, the protein–ligand binding enthalpy was calculated by the PM7 quantum-chemical method with the COSMO solvent model. Using the SOL score and the calculated protein–ligand binding enthalpies...
Source: Molecules - September 5, 2022 Category: Chemistry Authors: Alexey Sulimov Ivan Ilin Danil Kutov Khidmet Shikhaliev Dmitriy Shcherbakov Oleg Pyankov Nadezhda Stolpovskaya Svetlana Medvedeva Vladimir Sulimov Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5714: A Branched and Double Alpha-Gal-Bearing Synthetic Neoglycoprotein as a Biomarker for Chagas Disease
onica Suarez Douglas M. Watts Iliana R. Malo Janine M. Ramsey Belkisyolé Alarcón De Noya Oscar Noya Igor C. Almeida Katja Michael Chagas disease (CD) is caused by the parasite Trypanosoma cruzi and affects 6–7 million people worldwide. The diagnosis is still challenging, due to extensive parasite diversity encompassing seven genotypes (TcI-VI and Tcbat) with diverse ecoepidemiological, biological, and pathological traits. Chemotherapeutic intervention is usually effective but associated with severe adverse events. The development of safer, more effective therapies is hampered by the lack o...
Source: Molecules - September 5, 2022 Category: Chemistry Authors: Alba L. Montoya Elisa G. Carvajal Uriel Ortega-Rodriguez Igor L. Estevao Roger A. Ashmus Sohan R. Jankuru Susana Portillo Cameron C. Ellis Colin D. Knight Julio Alonso-Padilla Luis Izquierdo Maria-Jesus Pinazo Joaquim Gascon Veronica Suarez Douglas M. Wat Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5662: Nypa fruticans Frond Waste for Pure Cellulose Utilizing Sulphur-Free and Totally Chlorine-Free Processes
In this study, Nypa fruticans (nipa palm) fronds from agricultural residues were evaluated to produce pure cellulose by combining prehydrolysis for 1–3 h at 150 °C, sulfur-free soda cooking for 1–1.5 h at 160 °C with 13–25% active alkali (AA), 0.1% soluble anthraquinone (SAQ) catalyst, and three-stage totally chlorine-free (TCF) bleaching, namely oxygen, peroxymonosulfuric acid, and alkaline hydrogen peroxide stages. The optimal conditions were 3 h prehydrolysis and 1.5 h cooking with 20% AA. Soda cooking with SAQ was better than the kraft and soda process w...
Source: Molecules - September 2, 2022 Category: Chemistry Authors: Evelyn Sunarno David Andrio Azka Aman Hiroshi Ohi Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5648: Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides
During a screening performed by the National Cancer Institute in the 1960s, the terpenoid paclitaxel was discovered. Paclitaxel expanded the treatment options for breast, lung, prostate and ovarian cancer. Paclitaxel is only present in minute amounts in the bark of Taxia brevifolia. A sustainable supply was ensured with a culture developed from Taxus chinensis, or with semi-synthesis from other taxanes. Paclitaxel is marketed under the name Taxol. An intermediate from the semi-synthesis docetaxel is also used as a drug and marketed as Taxotere. O-Methylated docetaxel is used for treatment of some paclitaxel-resistant ...
Source: Molecules - September 1, 2022 Category: Chemistry Authors: S øren Brøgger Christensen Tags: Review Source Type: research