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The factors involved in the induction of neutrophil gelatinase-associated lipocalin overexpression in renal tubular epithelial cells under endoplasmic reticulum stress
This study investigated the factors involved when inducing NGAL overexpression in HK-2 cells during ERS. The cells were divided into six groups: the control group (normal HK-2 cells), the ERS group (HK-2 cells cultured in complete medium with thapsigargin (TG)), the transfection group (HK-2 cells transfected with activating transcription factor 4 small interfering ribonucleic acid (ATF4 siRNA), the ERS after transfection group (HK-2 cells transfected with ATF4 siRNA, then cultured in complete medium with TG), the negative control group (HK-2 cells transfected with siRNA-negative contrast), and the dimethyl sulfoxide (DMSO)...
Source: Journal of Physiology and Pharmacology - October 13, 2021 Category: Drugs & Pharmacology Authors: T Fu L Hou Y Du Source Type: research

Atorvastatin-induced endothelial nitric oxide synthase expression in endothelial cells is mediated by endoglin.
Authors: Zemankova L, Varejckova M, Dolezalova E, Fikrova P, Jezkova K, Rathouska J, Cerveny L, Botella LM, Bernabeu C, Nemeckova I, Nachtigal P Abstract Endoglin, a transforming growth factor β (TGF-β) receptor type III, is co-expressed with endothelial nitric oxide synthase (eNOS) in aortic endothelium in atherosclerotic plaques of mice. Interestingly, atorvastatin (ATV) is able to increase both endoglin and eNOS expression and reduce plaque size beyond its lipid lowering effects but by unknown mechanisms. We hypothesized whether inflammation modulates ATV-dependent induction of endoglin and eNOS expression in ...
Source: Journal of Physiology and Pharmacology - June 20, 2015 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research

Celastrol overcomes HSP72 gene silencing-mediated muscle atrophy and induces myofiber preservation.
Authors: Gwag T, Park K, Park J, Lee JH, Nikawa T, Choi I Abstract To elucidate a potential anabolic role of heat shock proteins (HSPs) in myofiber preservation, we assessed the effect of HSP70 gene silencing versus its overexpression on skeletal muscle atrophy or rescue. HSP72 gene expression was silenced by pre-treatment with HSP72 siRNA in cultured rat L6 myotubes, and the pro-anabolic effect of HSPs was examined in the absence or presence of the HSP inducer celastrol (CEL). Compared to the negative control (NC), both nuclear accumulation and phosphorylation of heat shock transcription factor 1 remained high und...
Source: Journal of Physiology and Pharmacology - April 24, 2015 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research

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