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Silencing c-Kit expression in human DCs suppresses Th2, Th17 response but enhances Th1 response.
Authors: Yang B, Yang Q, Huang Q, Yan H, Sun T, Tong H Abstract Dendritic cells (DCs) are integral to the differentiation of T helper cells into T helper type 1 TH1, TH2 and TH17 subsets. RNA interference (RNAi), which causes the degradation of any RNA in a sequence specific manner, is a posttranscriptional gene silencing mechanism. Targeting the c-Kit in DCs has been used as an approach to enhance antitumor immunity. Here, we shwed that transfection of DCs with siRNA specific for c-Kit gene can significantly knock down c-Kit. When exposed to TNF-α, immature DCs transfected with c-Kit siRNA can differentiate into ...
Source: American Journal of Translational Research - November 11, 2015 Category: Research Tags: Am J Transl Res Source Type: research