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Source: American Journal of Translational Research
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Total 412 results found since Jan 2013.
Down-regulation of Jun induces senescence through destabilizing chromatin in osteoarthritis chondrocytes
CONCLUSION: Jun plays a crucial role in OA development and causes senescence by destabilizing chromatin in chondrocytes. These findings provide new insights into OA progression and suggest promising therapeutic targets.PMID:37560235 | PMC:PMC10408544
Source: American Journal of Translational Research - August 10, 2023 Category: Research Authors: Ting Xie Xunshan Ren Huangming Zhuang Fuze Jiang Yuelong Zhang Panghu Zhou Source Type: research
Regulation of CRADD-caspase 2 cascade by histone deacetylase 1 in gastric cancer.
In this study, we found that CRADD was induced by TSA (trichostatin A) to activate caspase 2-dependent apoptosis. CRADD was downregulated in gastric cancer and the restoration of its expression suppressed the viability of gastric cancer cells. HDAC1 was responsible for its downregulation in gastric cancer since HDAC1 siRNA upregulated CRADD expression and HDAC1 directly bound to the promoter of CRADD. Therefore, the high expression of HDAC1 can downregulate CRADD to confer gastric cancer cells the resistance to caspase 2-dependent apoptosis. HDAC inhibitors, potential anti-cancer drugs under investigation, can promote casp...
Source: American Journal of Translational Research - November 14, 2014 Category: Research Tags: Am J Transl Res Source Type: research
Potential roles of Centipede Scolopendra extracts as a strategy against EGFR-dependent cancers.
This study might provide a novel therapy for cancer with high-EGFR expression.
PMID: 25755827 [PubMed]
Source: American Journal of Translational Research - March 12, 2015 Category: Research Tags: Am J Transl Res Source Type: research
DLAT subunit of the pyruvate dehydrogenase complex is upregulated in gastric cancer-implications in cancer therapy.
Authors: Goh WQ, Ow GS, Kuznetsov VA, Chong S, Lim YP
Abstract
An iTRAQ-based tandem mass spectrometry approach was employed to relatively quantify proteins in the membrane proteome of eleven gastric cancer cell lines relative to a denominator non-cancer gastric epithelial cell line HFE145. Of the 882 proteins detected, 57 proteins were found to be upregulated with > 1.3-fold change in at least 6 of the 11 cell lines. Bioinformatics analysis revealed that these proteins are significantly associated with cancer, cell growth and proliferation, death, survival and cell movement. The catalogue of membrane proteins p...
Source: American Journal of Translational Research - August 22, 2015 Category: Research Tags: Am J Transl Res Source Type: research
PGC-1 mediates the regulation of metformin in muscle irisin expression and function.
CONCLUSION: Our study demonstrates that Metformin stimulates irisin secretion from skeletal muscle into the circulation system of obese mice, and that PGC-1α is a critical regulator in this process.
PMID: 26692929 [PubMed]
Source: American Journal of Translational Research - December 26, 2015 Category: Research Tags: Am J Transl Res Source Type: research
MiRNA-125b inhibits proliferation and migration by targeting SphK1 in bladder cancer.
CONCLUSIONS: These findings suggest that miR-125b may act as a tumor suppressor gene in bladder cancer and that, in the future, targeting of this miRNA may provide a novel strategy for the diagnosis and treatment of patients with this lethal disease.
PMID: 26807182 [PubMed]
Source: American Journal of Translational Research - January 27, 2016 Category: Research Tags: Am J Transl Res Source Type: research
B7-H3 expression associates with tumor invasion and patient's poor survival in human esophageal cancer.
Authors: Chen L, Chen J, Xu B, Wang Q, Zhou W, Zhang G, Sun J, Shi L, Pei H, Wu C, Jiang J
Abstract
B7-H3, a member from B7-family co-stimulatory ligands, plays an important role in adaptive immune responses. In addition, recent studies also demonstrated that B7-H3 could be highly expressed in various types of human cancers, and its expression level was significantly associated with cancer patients' clinicopathological parameters and postoperative prognoses. As of now, the exact role of B7-H3 expression in human esophageal cancer still remains elusive. In the present study, we characterized the B7-H3 expression in ...
Source: American Journal of Translational Research - February 19, 2016 Category: Research Tags: Am J Transl Res Source Type: research
