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Predictors of Interstitial Lung Disease (ILD) in patients with Idiopathic Inflammatory Myopathy-associated (IIM)
Conclusions: Almost half of the overall IIM population develop ILD and showed lower CPK levels at diagnosis. Mechanic hands, anti Jo-1, antiMDA5, and anti-RO52 are the main independent predictors for the occurrence of ILD in patients with IIM.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Cocconcelli, E., Zanatta, E., Bellani, S., Castelli, G., Petrarulo, S., Iaccarino, L., Spagnolo, P., Balestro, E., Balestro, E. Tags: 12.02 - ILD/DPLD of known origin Source Type: research

Computed tomography morphometric analysis of idiopathic inflammatory myopathy related interstitial lung disease correlates with forced vital capacity
This study investigated muscle mass in IIM, and its relationship to ILD disease severity.Methods: A retrospective review of 31 patients undergoing treatment at a single institution from 2015–2021 was performed. CT scans at diagnosis and on clinical follow up underwent morphomic analysis using CoreSlicer, a web-based tool which enables semi-automated segmentation of muscle and fat. Bilateral Erector Spinae Muscle (ESM) and Pectoralis Muscle (PM) cross-sectional areas (CSA) were calculated. All morphomic data were correlated with lung function including forced vital capacity (FVC) and biochemical markers.Results: ...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: O'Mahony, A., Henry, P., Coghlan, P., Crowley, C., Ryan, D., Moore, N., Maher, M., O'Connor, O. J., Henry, M. Tags: 12.02 - ILD/DPLD of known origin Source Type: research

Progressive Idiopathic Inflammatory Myopathy-associated Interstitial Lung Diseases (IIM-ILDs)
Conclusions: Serological and clinical features at diagnosis may predict progression in IIM-ILD patients. Anti-MDA5 antibodies, heliotropic rash, xerostomia and xerophthalmia are prevalent in progressive IIM-ILD population, but their role as independent predictors need to be further investigated.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Cocconcelli, E., Zanatta, E., Giraudo, C., Castelli, G., Bernardinello, N., Fiorentu, G., Dartora, C., Iaccarino, L., Spagnolo, P., Balestro, E. Tags: 12.02 - ILD/DPLD of known origin Source Type: research

Extensive interstitial lung disease in inflammatory myopathy is a strong predictor of mortality
The objective of this study was to identify clinical predictors of mortality in a prospective cohort of subjects with IIM.Subjects were from the Canadian Inflammatory Myopathy Study group, a multicenter, prospective cohort of incident IIM. Clinical data, lung function were obtained per study protocol. Computed tomography scans (CT) of the chest done for clinical indications were reviewed by a respirologist for presence of ILD. Total lung involvement was estimated to the nearest 5%. Kaplan-Meier was used to identify survival differences between groups with and without ILD. Cox proportional hazard model identified predictors...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Assayag, D., Hirsch, A., Baron, M., Vinet, E., Albert, A., Fortin, P., Hudson, M. Tags: Diffuse Parenchymal Lung Disease Source Type: research