Filtered By:
Source: European Respiratory Journal

This page shows you your search results in order of date. This is page number 17.

Order by Relevance | Date

Total 2423 results found since Jan 2013.

Patient characteristics, biomarkers and exacerbation risk in severe, uncontrolled asthma
Conclusions Exacerbation history, maintenance corticosteroid use, nasal polyposis, Asian race, geographic region, and elevations in blood eosinophil counts and FENO concentrations (particularly when combined and/or persistently achieving type 2 inflammation criteria) were associated with increased exacerbation risk in patients with severe, uncontrolled asthma.
Source: European Respiratory Journal - December 16, 2021 Category: Respiratory Medicine Authors: Kraft, M., Brusselle, G., FitzGerald, J. M., Pavord, I. D., Keith, M., Fageras, M., Garcia Gil, E., Hirsch, I., Goldman, M., Colice, G. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Socioeconomic biases in asthma control and specialist referral of possible severe asthma
Conclusion Even in settings with nationally available free access to specialist care, the majority of patients with possible severe asthma are managed in primary care. Referral of at-risk asthma patients differs across socioeconomic parameters, calling for initiatives to identify and actively refer these patients.
Source: European Respiratory Journal - December 16, 2021 Category: Respiratory Medicine Authors: Hakansson, K. E. J., Backer, V., Ulrik, C. S. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy
Conclusion C4Ma3 levels depend on lung mast cell chymase and are increased in a severe, exacerbating allergic asthma phenotype. C4Ma3 may serve as a novel biomarker to predict anti-IgE therapy response.
Source: European Respiratory Journal - December 9, 2021 Category: Respiratory Medicine Authors: Weckmann, M., Bahmer, T., Sand, J. M., Rank Ronnow, S., Pech, M., Vermeulen, C., Faiz, A., Leeming, D. J., Karsdal, M. A., Lunding, L., Oliver, B. G. G., Wegmann, M., Ulrich-Merzenich, G., Juergens, U. R., Duhn, J., Laumonnier, Y., Danov, O., Sewald, K., Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Kidney function and obstructive lung disease: a bidirectional Mendelian randomisation study
Conclusion This study supports kidney function impairment as a causative factor for obstructive lung disease.
Source: European Respiratory Journal - December 9, 2021 Category: Respiratory Medicine Authors: Park, S., Lee, S., Kim, Y., Cho, S., Kim, K., Kim, Y. C., Han, S. S., Lee, H., Lee, J. P., Joo, K. W., Lim, C. S., Kim, Y. S., Kim, D. K. Tags: COPD and smoking, Asthma and allergy Original Articles: COPD and asthma Source Type: research

Whispers of change in childhood asthma: findings in the French ELFE cohort
Early life asthma phenotyping remains an unmet need in pediatric asthma; necessary to overcome the underdiagnoses and increased morbidity in childhood.  Phenotyping of asthma in France has been exclusively focused on severe pediatric asthma, and till date phenotypes of childhood asthma in the general population have not been ascertained. We aimed to determine wheezing profiles and asthma phenotypes in preschool children in French general population.Symptoms were determined using parental responses to modified versions of ISAAC questionnaire from 2 months to age 5. Supervised wheeze clusters were determined exclusively...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Khan, S., Ouaalaya, E. H., Leynaert, B., De Blic, J., Marguet, C., Deschildre, A., Dufourg, M.-N., Bois, C., Charles, M.-A., Delmas, M. C., Divaret Chauveau, A., Scherer, E., Rocchi, S., Reboux, G., Millon, L., Raherison Semjen, C. Tags: Epidemiology Source Type: research

Hospitalizations for asthma in men and women - data analysis from 2014-2017
Conclusions: although there was a higher proportion of women hospitalized for asthma in the investgated group, our results suggest that asthma exacerbations which require hospitalization in women are not characterized by distinct features and do not differ in course, outcome and economic burden from exacerbations treated in the hospital setting in men.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Białek-Gosk, K., Maskey-Warzechowska, M., Strzelczyk, J., Białek, S. Tags: Epidemiology Source Type: research

Associations between TARC/TSLP with asthma characteristics in adults: the EGEA study
Thymus and Activation Regulated Chemokine (TARC) and Thymic Stromal Lymphopoeitin (TSLP) are involved in the pro-Th2 inflammatory response. To date, there is no epidemiological studies that have simultaneously investigated TARC and TSLP with various asthma characteristics and allergy in adults.We investigated the associations between TARC/TSLP and various asthma and allergic characteristics in the Epidemiological study on the Genetics and Environment of Asthma (EGEA).Cross-sectional analyses were performed at EGEA2 (second survey, 2003-2007). Asthma characteristics were defined by standardized questionnaires and lung funct...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: IBRAHIM, B., Achour, D., Zerimech, F., De Nadai, P., Siroux, V., Tsicopoulos, A., Matran, R., Granger, V., Nadif, R. Tags: Epidemiology Source Type: research

Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling
Conclusion This study demonstrates a metabolic switch towards mitochondrial β-oxidation in asthmatic BSM and identifies fatty acid metabolism as a new key target to reduce BSM remodelling in asthma.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Esteves, P., Blanc, L., Celle, A., Dupin, I., Maurat, E., Amoedo, N., Cardouat, G., Ousova, O., Gales, L., Bellvert, F., Begueret, H., Thumerel, M., Dupuy, J.-W., Desbenoit, N., Marthan, R., Girodet, P.-O., Rossignol, R., Berger, P., Trian, T. Tags: Lung biology and experimental studies, Asthma and allergy Original Articles: Asthma and basic science Source Type: research

A clinical prediction model to support asthma diagnosis in children and young people in UK primary care
Conclusion: Information from a patient’s electronic health records can support primary care clinicians to assess the likelihood of a child/young person having asthma. Before implementation, we will externally validate the prediction model, develop it into a user-friendly clinical decision support software, and test the feasibility of the system in clinical practice.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Daines, L., Bonnett, L., Tibble, H., Boyd, A., Turner, S., Lewis, S., Sheikh, A., Pinnock, H. Tags: General practice and primary care Source Type: research

Diary-reported symptoms, medication use, and peak expiratory flow (PEF) in an asthma panel in two Swedish cities
In this study, subjects with physician-diagnosed asthma and allergy to birch kept symptom diaries and recorded morning and evening PEF for 70 days during two pollen seasons (April – June) in two Swedish cities. Daily exposure levels were assigned from central monitoring stations. Logistic and linear mixed models with individual and city as random effects were used.38 subjects were included, mean age 49±13 years, 50% women. Pollution concentrations were moderate (24-hour mean PM2.5 6.5, NOX 21.6 and O3 65.0µg/m3) and median pollen was 68 pollen grains/m3 in the study period. Pollen levels above media...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Carlsen, H. K., Behndig, A., Lohman-Haga, S., Modig, L., Olin, A.-C. Tags: Occupational and environmental health Source Type: research

Molecular characterization of bronchoconstriction induced by activated T cells
Conclusions: T cell activation caused airflow limitation in addition to eosinophilic inflammation, AHR, and mucous hyperplasia. T cell-derived bronchoconstriction seems a good target for treatment-resistant asthma.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Mori, A., Kouyama, S., Yamaguchi, M., Kumitani, C., Ohtomo-Abe, A., Kawasaki, Y., Iwamoto, K., Yano, K., Iwata, M., Nagayama, K., Ryu, K., Nakamura, Y., Hamada, Y., Watai, K., Kamide, Y., Sekiya, K., Fukutomi, Y., Ohtomo, T., Kaminuma, O. Tags: Allergy and immunology Source Type: research

Peculiarities of lipoperoxidation processes in chronic obstructive pulmonary disease associated with multiple myeloma
Conclusion: In patients with COPD with MM and MM, oxidative stress was revealed, proved by a multiple increase in MDA in the blood serum, while MDA values were significantly higher when COPD was combined with MM. The development of oxidative stress aggravates the symptoms of bronchial obstruction in COPD with MM.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Smirnova, O. Tags: Allergy and immunology Source Type: research

ILC2 cells from severe allergic and eosinophilic asthma demonstrate increased expression of TSLP receptor (TSLPR) and enhanced proliferative capacity
Conclusion: ILC2s from SA subjects demonstrate increased TSLPR expression that significantly correlated with increased proliferative capacity and secretion of IL-5 & IL-13
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Malik, B., Mckerrow, R., Harrington, J., W. Upham, J., Bartlett, N., Ab Wark, P. Tags: Allergy and immunology Source Type: research

Does parental tuberculosis infection increase the risk of asthma in their offspring? A Norwegian registry-based study
Conclusions: Parental tuberculosis infection in childhood was associated with higher risk of asthma in their future offspring. We speculate that tuberculosis may have profound impact that may be transferred to offspring, the nature of such impact needs further study.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Lopez-Cervantes, J. P., Shigdel, R., Mustafa, T., Svanes, C. Tags: Allergy and immunology Source Type: research

Correlation of eotaxin-3 gene expression and other IL-13-induced genes in patients with asthma
Conclusion: Eotaxin-3 gene expression is upregulated in the airway epithelium in eosinophilic asthma and highly correlates with IL-13 signature genes – including biomarker genes POSTN and NOS2.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Couillard, S., Melhorn, J., Singhania, A., Horowitz, D., Djukanovic, R., Woelk, C. H., Hinks, T. S. C. Tags: Allergy and immunology Source Type: research