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Source: European Respiratory Journal
Infectious Disease: Influenza

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Total 25 results found since Jan 2013.

Impaired cytokine production of circulating immune cells in severe asthma in response to Influenza virus
Conclusion: Impaired cytokine responses to acute IAV infection could explain the increased susceptibility to IAV in asthma and the increase in inflammation in exacerbations. This implicates a systemic immunodeficiency leading to an impaired activation of circulating leukocytes after recruitment to the infected tissue.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Jamal Jameel, K., Yanik, S., Kamaci, C., Weidinger, D., Buelthoff, E., Rohde, S., Yusuf, F., Kronsbein, J., Tenbusch, M., Knobloch, J. Tags: 05.03 - Allergy and immunology Source Type: research

Enhanced early T cell activation and protection from hyper-inflammation in smoke exposed Cox4i2-/- infected mice with influenza
Respiratory virus infections are a major cause of concern in chronic obstructive pulmonary disease (COPD). Mitochondrial reactive oxygen species (mtROS) play an important role in immune function and increased mtROS levels may have an effect in COPD. Cox4i2 regulates ROS production at complex III and has been shown implicated in the development of emphysema.We hypothesize that Cox4i2–/– mice are protected from smoke-induced hyper-inflammation but also exhibit impaired T cell activation and antiviral immunity.We analyzed T cell subsets, BAL Albumin leakage and virus load via qPCR. C57BL/6 (WT) and Cox4i2–/&...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Berger, T., Garcia Castro, C. F., Lakshmi, V., Völkel, S., Sommer, N., Skevaki, C. Tags: 05.03 - Allergy and immunology Source Type: research

The impact of COVID-19 on patients with asthma
Conclusion Patients with asthma and COVID-19 were older and at increased risk due to comorbidity-related factors. ICS and biologics are generally safe and may be associated with a protective effect against severe COVID-19 infection.
Source: European Respiratory Journal - March 4, 2021 Category: Respiratory Medicine Authors: Izquierdo, J. L., Almonacid, C., Gonzalez, Y., Del Rio-Bermudez, C., Ancochea, J., Cardenas, R., Lumbreras, S., Soriano, J. B. Tags: Respiratory infections and tuberculosis Original Articles: Pulmonary infections Source Type: research

Microbiome landscape and disease duration role in allergy in adult patients with bronchiectasis
Conclusions: 1) The study showed that a longer DD and chronic colonization by pathogens are associated with higher levels of TS IgE in pts with B. 2) The most common pathogens are PA and HI in pts with B in Dnipro.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Gashynova, K., Suska, K., Dmytrychenko, V. Tags: Allergy and immunology Source Type: research

Treatment with Omalizumab in adults with severe allergic reduces Fc?I expression on dendritic cells and improves antiviral responses
Conclusion: Adults with severe allergic asthma demonstrate impaired systemic DC immune responses to IAV and RV. Treatment with Omalizumab, that results in reduced exacerbations is associated with reduced DC FcI expression, enhanced DC IFN-α/ responses to viruses and this effect is seen within 4 weeks treatment.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Wark, P., Nichol, K., Dorahy, D., Collison, A., Mattes, J. Tags: Allergy and immunology Source Type: research

Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza
Conclusions Asthma is common in those hospitalised with influenza, but may not represent classical type 2-driven disease. Those admitted with influenza tend to be female with mild serum inflammatory responses, increased serum IFN-α levels and good clinical outcomes.
Source: European Respiratory Journal - October 23, 2019 Category: Respiratory Medicine Authors: Jha, A., Dunning, J., Tunstall, T., Thwaites, R. S., Hoang, L. T., The MOSAIC Investigators, Kon, O. M., Zambon, M. C., Hansel, T. T., Openshaw, P. J. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Clinical and microbiological status in asthmatic preschool children during a severe exacerbation: the VIRASTHMA 2 study
Conclusion: We confirmed the severe intermittent asthma phenotype, characterized by atopic features. Severe Ex were triggered by viruses (hRV), frequently associated with bacteria. Virus carriage was observed at steady state. Despite maintenance treatment with ICS, control was frequently not obtained.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Lejeune, S., Gosset, P., Engelman, I., Dewilde, A., Dessein, R., Pouessel, G., Ducoin, H., Mitha, S., Delvart, C., Boileau, S., Le Mee, A., Bonnel, C., Thumerelle, C., Mordacq, C., Pichavant, M., Deschildre, A. Tags: Paediatric Respiratory Infection and Immunology Source Type: research

Late Breaking Abstract - IL-33 drives influenza-induced exacerbations of asthma by halting anti-viral and Th1 responses
Conclusion: Blocking IL33 attenuates virus-induced airway inflammation in HDM-sensitized and naïve mice, but does not affect AHR. IL-33 attenuates the anti-viral and Th1 responses, which result in a prolonged inflammation that leads to asthma exacerbations.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Ravanetti, L., Dijkhuis, A., Sabogal Pineros, Y., Lutter, R. Tags: Allergy and immunology Source Type: research

Th22 cells develop independently of the Th17 lineage with unique transcriptional properties and plasticity toward Th1-type cells during Influenza infection
Introduction: Interleukin (IL)-22 is expressed in mucosal tissues during infections and chronic inflammatory diseases (e.g asthma and COPD). Th22 cells are a major source of IL-22 and have been identified in inflammatory infiltrates in patients suffering from asthma, cystic fibrosis, COPD, and RSV infection. However, their molecular characteristics and functional roles remain largely unknown.Results: We have generated novel dual IL-22/IL-17A reporter mice to identify, isolate and characterise Th17 and Th22 cells in vitro and in vivo. We have further identified a new differentiation assay to generate large numbers of Th22 c...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Plank, M., Kaiko, G., Maltby, S., Weaver, J., Tay, H., Wei, S., Wilson, M., Durum, S., Foster, P. Tags: Allergy and immunology Source Type: research

Factors influencing on influenza vaccination among south korean adult asthma: a nationwide population-based cross-section study
Conclusions: Attention and interventions are required to improve the influenza vaccination coverage for the non-elderly patients with asthma, especially on those who are taking no regular exercise, thinking self as being healthy, taking irregular health check-up.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Han, C. H., Chung, J. H. Tags: Allergy and immunology Source Type: research

Identification of therapeutic targets for steroid-insensitive asthma using models that represent different clinical subtypes of disease
Conclusion: We have developed unique models of SI asthma and used these models to identify factors that are universally dysregulated in SI disease. These factors may represent novel targets for therapies that are broadly effective for the treatment of different subtypes of SI asthma in humans.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Horvat, J., Kim, R., Pinkerton, J., Rae, B., Starkey, M., Essilfie, A.-T., Mayall, J., Jones, B., Haw, T. J., Nguyen, H., Keely, S., Mattes, J., Adcock, I., Foster, P., Hansbro, P. Tags: 5.3 Allergy and Immunology Source Type: research

LATE-BREAKING ABSTRACT: IL33 drives humoral and cellular immune response in influenza-induced severe exacerbation of experimental asthma
Conclusion. Blocking IL33 dampens airway inflammation and virus-induced changes in HDM-sensitized mice, prevents the recruitment into the lumen of inflammatory subsets from the lung sub-mucosa and into mLNs, affecting, potentially even directly, the migration of not only GATA3-expressing cells.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Ravanetti, L., Dijhuis, A., Sabogal Pineros, Y., Lutter, R. Tags: 5.3 Allergy and Immunology Source Type: research

Influenza induced exacerbation is associated with steroid insensitive AHR and pulmonary inflammation in HDM-sensitised mice
Conclusion: IAV exacerbates the pulmonary inflammation and AHR seen in HDM sensitised animals with an effect that is steroid in-sensitive. This closely resembles what is seen in man and therefore this model may be useful for the evaluation of novel compounds in the treatment of viral induced exacerbation in asthma.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Knowles, I., Lalgi, K., Elmi, M., Robb, O., Patel, N. Tags: 5.3 Allergy and Immunology Source Type: research

Seasonal influenza vaccine effectiveness in people with asthma: A systematic review
Conclusions: Separate meta-analyses for experimental and observational studies will be carried out to explore the protective and/or adverse effects of influenza vaccine in people with asthma.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Vasileiou, E., Simpson, C., Sheikh, A., Butler, C. Tags: 5.3 Allergy and Immunology Source Type: research

Provision of influenza immunisation for UK HIV positive adults
Conclusion: We found high levels of awareness of the need for FI, and reasonable uptake. Most immunisations were provided by GP practices, although one-quarter prefer to be immunised in their HIV care service. Resources for influenza immunisation of HIV positive individuals should facilitate patient choice.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Pickett, E., Van Schalkwyk, M., Brown, J., Edwards, K., Marshall, N., Edwards, S., Sathia, L., Johnson, M., Lipman, M. Tags: 10.1 Respiratory Infections Source Type: research