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Source: Frontiers in Immunology
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Total 269 results found since Jan 2013.
Preventive Administration of Non-Allergenic Bet v 1 Peptides Reduces Allergic Sensitization to Major Birch Pollen Allergen, Bet v 1
IgE-mediated allergy to birch pollen affects more than 100 million patients world-wide. Bet v 1, a 17 kDa protein is the major allergen in birch pollen responsible for allergic rhinoconjunctivitis and asthma in birch pollen allergic patients. Allergen-specific immunotherapy (AIT) based on therapeutic administration of Bet v 1-containing vaccines is an effective treatment for birch pollen allergy but no allergen-specific forms of prevention are available. We developed a mouse model for IgE sensitization to Bet v 1 based on subcutaneous injection of aluminum-hydroxide adsorbed recombinant Bet v 1 and performed a detailed cha...
Source: Frontiers in Immunology - October 26, 2021 Category: Allergy & Immunology Source Type: research
The Interactions Between Autoinflammation and Type 2 Immunity: From Mechanistic Studies to Epidemiologic Associations
Autoinflammatory diseases are a group of clinical syndromes characterized by constitutive overactivation of innate immune pathways. This results in increased production of or responses to monocyte- and neutrophil-derived cytokines such as interleukin-1β (IL-1β), Tumor Necrosis Factor-α (TNF-α), and Type 1 interferon (IFN). By contrast, clinical allergy is caused by dysregulated type 2 immunity, which is characterized by expansion of T helper 2 (Th2) cells and eosinophils, as well as overproduction of the associated cytokines IL-4, IL-5, IL-9, and IL-13. Traditionally, type 2 immune cells and autoinflammatory effectors ...
Source: Frontiers in Immunology - February 24, 2022 Category: Allergy & Immunology Source Type: research
Claudin-1 Mediated Tight Junction Dysfunction as a Contributor to Atopic March
Atopic march refers to the phenomenon wherein the occurrence of asthma and food allergy tends to increase after atopic dermatitis. The mechanism underlying the progression of allergic inflammation from the skin to gastrointestinal (GI) tract and airways has still remained elusive. Impaired skin barrier was proposed as a risk factor for allergic sensitization. Claudin-1 protein forms tight junctions and is highly expressed in the epithelium of the skin, airways, and GI tract, thus, the downregulation of claudin-1 expression level caused by CLDN-1 gene polymorphism can mediate common dysregulation of epithelial barrier funct...
Source: Frontiers in Immunology - June 29, 2022 Category: Allergy & Immunology Source Type: research
A real-world retrospective study of safety, efficacy, compliance and cost of combination treatment with rush immunotherapy plus one dose of pretreatment anti-IgE in Chinese children with respiratory allergies
ConclusionsRIT + 1 dose of pretreatment anti-IgE combination has practical advantages over CIT, including comparable safety, better compliance, and probably a faster onset of clinical efficacy at no additional cost, so it can be an useful regimen for the treatment of Chinese children with respiratory allergies.
Source: Frontiers in Immunology - October 4, 2022 Category: Allergy & Immunology Source Type: research
The clinical significance of allergen-specific IgG4 in allergic diseases
IgG4 is a subclass of IgG antibody with a unique molecular feature of (Fragment antigen- binding) Fab-arm exchange, allowing bispecific antigen binding in a mono-valent manner. With low binding affinity to C1q and Fcγreceptors, IgG4 is incapable of forming immune complexes and activating the complement pathway, exhibiting a non-inflammatory feature. IgG4 is produced similarly to IgE and is considered a modified reaction to IgE class-switching response under certain conditions. It could also counteract IgE-activated inflammation. However, the clinical significance of IgG4 in allergic diseases is complex and controversial. ...
Source: Frontiers in Immunology - October 25, 2022 Category: Allergy & Immunology Source Type: research
Helicobacter pylori-Mediated Protection from Allergy Is Associated with IL-10-Secreting Peripheral Blood Regulatory T Cells
Khiyam Hussain, Darren P. Letley, A. Borgel Greenaway, Rupert Kenefeck, Jody A. Winter, William Tomlinson, Joanne Rhead, Emily Staples, Kazuyo Kaneko, John C. Atherton, Karen Robinson
Source: Frontiers in Immunology - March 7, 2016 Category: Allergy & Immunology Source Type: research
Novel Modulators of Asthma and Allergy: Exosomes and MicroRNAs
Beatriz Sastre, Jos é A. Cañas, José M. Rodrigo-Muñoz, Victoria del Pozo
Source: Frontiers in Immunology - July 21, 2017 Category: Allergy & Immunology Source Type: research
Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow ’s Milk Allergy Model: A Potential Role for Foxp3+ Regulatory T Cells
Marlotte M. Vonk, Mara A. P. Diks, Laura Wagenaar, Joost J. Smit, Raymond H. H. Pieters, Johan Garssen, Betty C. A. M. van Esch, L éon M. J. Knippels
Source: Frontiers in Immunology - September 29, 2017 Category: Allergy & Immunology Source Type: research
Dietary Intervention with β-Lactoglobulin-Derived Peptides and a Specific Mixture of Fructo-Oligosaccharides and Bifidobacterium breve M-16V Facilitates the Prevention of Whey-Induced Allergy in Mice by Supporting a Tolerance-Prone Immune Environment
Atanaska I. Kostadinova, Alba Pablos-Tanarro, Mara A. P. Diks, Betty C. A. M. van Esch, Johan Garssen, L éon M. J. Knippels, Linette E. M. Willemsen
Source: Frontiers in Immunology - October 23, 2017 Category: Allergy & Immunology Source Type: research
The Kynurenine Pathway As a Novel Link between Allergy and the Gut Microbiome
Aaron P. Van der Leek, Yarden Yanishevsky, Anita L. Kozyrskyj
Source: Frontiers in Immunology - November 6, 2017 Category: Allergy & Immunology Source Type: research
Bifidobacterium infantis Potentially Alleviates Shrimp Tropomyosin-Induced Allergy by Tolerogenic Dendritic Cell-Dependent Induction of Regulatory T Cells and Alterations in Gut Microbiota
Linglin Fu, Jinyu Song, Chong Wang, Shujie Fu, Yanbo Wang
Source: Frontiers in Immunology - November 10, 2017 Category: Allergy & Immunology Source Type: research
Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice
Dagbjort H. Petursdottir, Sofia Nordlander, Khaleda Rahman Qazi, Claudia Carvalho-Queiroz, Omneya Ahmed Osman, Eva Hell, Sophia Bj örkander, Yeneneh Haileselassie, Marit Navis, Efthymia Kokkinou, Ivan Zong Long Lio, Julia Hennemann, Björn Brodin, Douglas L. Huseby, Caroline Nilsson, Diarmaid Hughes, Klas I. Udekwu, Eva Sverremark-Ekström
Source: Frontiers in Immunology - December 1, 2017 Category: Allergy & Immunology Source Type: research
Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma
V éronique Schulten, Luise Westernberg, Giovanni Birrueta, John Sidney, Sinu Paul, Paula Busse, Bjoern Peters, Alessandro Sette
Source: Frontiers in Immunology - February 13, 2018 Category: Allergy & Immunology Source Type: research
Intestinal Epithelial Cells Regulate Gut Eotaxin Responses and Severity of Allergy
Eunsoo Kim, Melanie Lembert, Ghaith M. Fallata, John C. Rowe, Tara L. Martin, Abhay R. Satoskar, Nicholas V. Reo, Oleg Paliy, Estelle Cormet-Boyaka, Prosper N. Boyaka
Source: Frontiers in Immunology - August 3, 2018 Category: Allergy & Immunology Source Type: research
The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets
Elden Berla Thangam, Ebenezer Angel Jemima, Himadri Singh, Mirza Saqib Baig, Mahejibin Khan, Clinton B. Mathias, Martin K. Church, Rohit Saluja
Source: Frontiers in Immunology - August 13, 2018 Category: Allergy & Immunology Source Type: research
