Filtered By:
Source: Frontiers in Immunology

This page shows you your search results in order of relevance. This is page number 18.

Order by Relevance | Date

Total 269 results found since Jan 2013.

Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies
ConclusionBasophils barely express MRGPRX2 in resting conditions. However, the receptor can be quickly upregulated after stimulation with anti-IgE, fMLP, or after purification, making cells responsive to MRGPRX2 occupation. We anticipate that such “conditioned” basophils constitute a model to explore MRGPRX2 agonism or antagonism, including IDHRs originating from the occupation of this receptor.
Source: Frontiers in Immunology - January 16, 2023 Category: Allergy & Immunology Source Type: research

Modulation by luminal factors on the functions and migration of intestinal innate immunity
Luminal antigens, nutrients, metabolites from commensal bacteria, bile acids, or neuropeptides influence the function and trafficking of immune cells in the intestine. Among the immune cells in the gut, innate lymphoid cells, including macrophages, neutrophils, dendritic cells, mast cells, and innate lymphoid cells, play an important role for the maintenance of intestinal homeostasis through a rapid immune response to luminal pathogens. These innate cells are influenced by several luminal factors, possibly leading to dysregulated gut immunity and intestinal disorders such as inflammatory bowel disease (IBD), irritable bowe...
Source: Frontiers in Immunology - February 13, 2023 Category: Allergy & Immunology Source Type: research

The mast cell: A Janus in kidney transplants
Mast cells (MCs) are innate immune cells with a versatile set of functionalities, enabling them to orchestrate immune responses in various ways. Aside from their known role in allergy, they also partake in both allograft tolerance and rejection through interaction with regulatory T cells, effector T cells, B cells and degranulation of cytokines and other mediators. MC mediators have both pro- and anti-inflammatory actions, but overall lean towards pro-fibrotic pathways. Paradoxically, they are also seen as having potential protective effects in tissue remodeling post-injury. This manuscript elaborates on current knowledge ...
Source: Frontiers in Immunology - February 20, 2023 Category: Allergy & Immunology Source Type: research

Proteomic characterisation of perhexiline treatment on THP-1 M1 macrophage differentiation
ConclusionThis is the first study to report on the action of PHX on THP-1 macrophage polarization and the associated changes in the proteome of these cells.
Source: Frontiers in Immunology - March 13, 2023 Category: Allergy & Immunology Source Type: research

Breast milk microRNAs: Potential players in oral tolerance development
Breast milk is an essential source of nutrition and hydration for the infant. In addition, this highly complex biological fluid contains numerous immunologically active factors such as microorganisms, immunoglobulins, cytokines and microRNAs (miRNAs). Here, we set out to predict the function of the top 10 expressed miRNAs in human breast milk, focusing on their relevance in oral tolerance development and allergy prevention in the infant. The top expressed miRNAs in human breast milk were identified on basis of previous peer-reviewed studies gathered from a recent systematic review and an updated literature search. The miRN...
Source: Frontiers in Immunology - March 14, 2023 Category: Allergy & Immunology Source Type: research

A flagellin-conjugate protein induces dual NLRC4- and NLRP3-inflammasome activation which modulates inflammatory cytokine secretion from macrophages
ConclusionThe mechanisms contributing to rFlaA:Betv1-induced IL-1β secretion from macrophages were shown to be complex, involving both NLRC4- and NLRP3-inflammsomes, as well as NFκB- and SAP/JNK MAP kinase-signaling. Better understanding the mechanisms regulating the activation of immune cells by novel therapeutic candidates like the rFlaA:Betv1 fusion protein will allow us to further improve and develop new treatment strategies when using flagellin as an adjuvant.
Source: Frontiers in Immunology - March 21, 2023 Category: Allergy & Immunology Source Type: research

Current research into A20 mediation of allergic respiratory diseases and its potential usefulness as a therapeutic target
Allergic airway diseases are characterized by excessive and prolonged type 2 immune responses to inhaled allergens. Nuclear factor κB (NF-κB) is a master regulator of the immune and inflammatory response, which has been implicated to play a prominent role in the pathogenesis of allergic airway diseases. The potent anti-inflammatory protein A20, termed tumor necrosis factor-α-inducible protein 3 (TNFAIP3), exerts its effects by inhibiting NF-κB signaling. The ubiquitin editing abilities of A20 have attracted much attention, resulting in its identification as a susceptibility gene in various autoimmune and inflammatory d...
Source: Frontiers in Immunology - March 28, 2023 Category: Allergy & Immunology Source Type: research

Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years
ConclusionThe effect of FHA and common lifestyle factors on food sensitization did not significantly change during 2009−2019. However, the influence of demographic characteristics on food sensitization has changed since 2009; that is, older age, male gender, and only child are more likely to develop food sensitization, which needs to be considered in future epidemiological surveys.Clinical Trial Registrationhttp://www.chictr.org.cn/, identifier ChiCTR1900024338.
Source: Frontiers in Immunology - March 31, 2023 Category: Allergy & Immunology Source Type: research

Serological analysis of allergic components of house dust mite provides more insight in epidemiological characteristics and clinical symptom development in North China
ConclusionHDM groups 1 and 2 were the major sensitizing allergens, with group 2 being the most important component relevant to respiratory symptoms in North China. The Der p 10 sensitization tends to increase with age. Der p 21 and Der p 23 might be associated with the development of allergic skin disease and asthma, respectively. Multiple allergen sensitizations increased the risk of allergic asthma.
Source: Frontiers in Immunology - April 27, 2023 Category: Allergy & Immunology Source Type: research

The role of PD-1 signaling in health and immune-related diseases
Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to mediate the mechanism of immune tolerance and provide immune homeostasis. Significantly, the binding partners of PD-1 and its associated ligands are diverse, which facilitates immunosuppression in cooperation with other immune checkpoint proteins. Accumulating evidence has demonstrated the important immunosuppressive role of the PD-1 axis in the tumor microenvironment and in autoimmune diseases. In addition, PD-1 blockades have been approved to treat various cancers, including solid tumors and hematological malignancies. Here, we pr...
Source: Frontiers in Immunology - May 16, 2023 Category: Allergy & Immunology Source Type: research

Case Report: A novel IRF2BP2 mutation in an IEI patient with recurrent infections and autoimmune disorders
ConclusionWe identified a novel IRF2BP2 mutation in a family with a member diagnosed with IEI. Immune monitoring and WGS as auxiliary tests are helpful in identifying genetic defects and assisting diagnosis in patients with clinically highly suspected immune abnormalities and deficiencies in inflammation regulation. In addition, mNGS techniques allow a more comprehensive assessment of the pathogenic characteristics of these patients. This report further validates the association of IRF2BP2 deficiency and IEI, and expands IEI phenotypes.
Source: Frontiers in Immunology - June 7, 2023 Category: Allergy & Immunology Source Type: research

Intra-cervical lymphatic immunotherapy for dust mite-induced allergic rhinoconjunctivitis in children: a 3-year prospective randomized controlled trial
ConclusionICLIT could ameliorate significantly the allergic symptoms in pediatric patients with an advantage in effectiveness and safety, besides an improved life quality including shortened period of treatment, frequency of drug use and pain perception.Clinical trial registrationhttps://www.chictr.org.cn/, identifier ChiCTR1800017130.
Source: Frontiers in Immunology - August 1, 2023 Category: Allergy & Immunology Source Type: research

Influenza breakthrough infection in vaccinated mice is characterized by non-pathological lung eosinophilia
Eosinophils are important mediators of mucosal tissue homeostasis, anti-helminth responses, and allergy. Lung eosinophilia has previously been linked to aberrant Type 2-skewed T cell responses to respiratory viral infection and may also be a consequence of vaccine-associated enhanced respiratory disease (VAERD), particularly in the case of respiratory syncytial virus (RSV) and the formalin-inactivated RSV vaccine. We previously reported a dose-dependent recruitment of eosinophils to the lungs of mice vaccinated with alum-adjuvanted trivalent inactivated influenza vaccine (TIV) following a sublethal, vaccine-matched H1N1 (A...
Source: Frontiers in Immunology - August 4, 2023 Category: Allergy & Immunology Source Type: research

Corrigendum: The human milk proteome and allergy of mother and child: exploring associations with protein abundances and protein network connectivity
Source: Frontiers in Immunology - September 18, 2023 Category: Allergy & Immunology Source Type: research