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Eosinophilic Esophagitis: Latent Disease in Patients with Anaphylactic Reaction to Cow's Milk
Conclusions This description demands scientific attention because it is the highest frequency of esophageal eosinophilia yet described in a group of patients with cow's milk allergy presenting with anaphylaxis. Eosinophilic esophagitis is a condition that can coexist “silently” with an IgE-mediated food allergy and is most often underestimated and underdiagnosed.
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 26, 2017 Category: Allergy & Immunology Source Type: research

Gene Expression Patterns in Distinct Endoscopic Findings for Eosinophilic Gastritis in Children
Conclusions Our results strongly indicate that ulcerative and nodular lesions are a single disease, EG, or a variation thereof, in spite of morphological differences. Our findings may contribute to a better understanding of the pathogenesis of EG, as well as to more accurate diagnosis of this disease.
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 17, 2017 Category: Allergy & Immunology Source Type: research

Biotherapeutics in Chronic Rhinosinusitis with and without Nasal Polyps
Publication date: Available online 16 May 2017 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Claus Bachert, Philippe Gevaert, Peter Hellings In western countries, 85% of chronic rhinosinusitis with nasal polyp disease reveals a type 2 inflammatory pattern with expression of IL-4, -5, and -13 as well as increased concentrations of IgE, whereas chronic rhinosinusitis without nasal polyps merely expresses these biomarkers. The degree of type 2 inflammation furthermore is associated with disease severity, asthma comorbidity, and recurrence of disease after surgery. Therefore, these biomarkers a...
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 17, 2017 Category: Allergy & Immunology Source Type: research

Other Phenotypes and Treatment of Chronic Rhinosinusitis
This article comments on some factors that are believed to influence the expression of CRS. These factors include anatomic abnormalities, immotile cilia, age, allergic sensitization, immune deficiency, dental infections, gastrointestinal reflux, smoking, biofilm, and the microbiome. Other factors are discussed in other sections. The article concludes with an overview of treatment. In brief, nasal steroids and large volume nasal irrigations are the first line of treatment for this inflammatory disease. Antibiotics are used when infections are thought to contribute. Oral steroids are frequently used in severe disease. Endosc...
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 6, 2016 Category: Allergy & Immunology Source Type: research

Phenotypes and Emerging Endotypes of Chronic Rhinosinusitis
Publication date: July–August 2016 Source:The Journal of Allergy and Clinical Immunology: In Practice, Volume 4, Issue 4 Author(s): Claus Bachert, Cezmi A. Akdis Chronic rhinosinusitis can be differentiated into several phenotypes based on clinical criteria; however, these phenotypes do not teach us much about the underlying inflammatory mechanisms. Thus, the use of nasal endoscopy and CT scanning, and eventually taking a swab or a biopsy, may not be sufficient to fully appreciate the individual patient's pathology. Endotyping of chronic rhinosinusitis on the basis of pathomechanisms, functionally and pathologically ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 6, 2016 Category: Allergy & Immunology Source Type: research

Asthma Control and Airway Inflammation in Patients with Eosinophilic Granulomatosis with Polyangiitis
Conclusions Systemic treatment controls systemic involvement in EGPA, but not asthma and nasal diseases, which negatively affects patients' quality of life.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 5, 2016 Category: Allergy & Immunology Source Type: research