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Source: The Journal of Allergy and Clinical Immunology: In Practice

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Anaphylaxis in the Pediatric Emergency Department: Analysis of 133 Cases After an Allergy Workup
Conclusions The incidence of anaphylaxis is higher in children than previously reported in adults from the same center, and food is the trigger in most cases. To prevent erroneous diagnoses, the etiology of anaphylaxis should be established after an appropriate workup.
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 25, 2017 Category: Allergy & Immunology Source Type: research

The Importance of Prolonged Provocation in Drug Allergy — Results From a Danish Allergy Clinic
Conclusions Only 11.0% of the provocations were positive. Importantly, only 1 of 5 patients tested positive on the first dose, indicating that prolonged exposure should always be considered when drug provocation is included in allergy investigations. Most provocations were with penicillins, reflecting the pattern of antibiotic use in Denmark, which differs from that in other countries, especially outside Northern Europe.
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 26, 2017 Category: Allergy & Immunology Source Type: research

The 3 Cs of Antibiotic Allergy —Classification, Cross-Reactivity, and Collaboration
Publication date: Available online 23 August 2017 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Jason A. Trubiano, Cosby A. Stone, M. Lindsay Grayson, Karen Urbancic, Monica A. Slavin, Karin A. Thursky, Elizabeth J. Phillips Antibiotic allergy labeling is highly prevalent and negatively impacts patient outcomes and antibiotic appropriateness. Reducing the prevalence and burden of antibiotic allergies requires the engagement of key stakeholders such as allergists, immunologists, pharmacists, and infectious diseases physicians. To help address this burden of antibiotic allergy overlabeling, w...
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 24, 2017 Category: Allergy & Immunology Source Type: research

Cocaine Allergy in Drug-Dependent Patients and Allergic People
Conclusions Cocaine may be an important allergen. Drug abusers and patients sensitized to local anesthesia and tobacco are at risk. Both prick tests and specific IgE against coca leaf extract detected sensitization to cocaine. The highest levels were related to severe clinical profiles.
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 30, 2017 Category: Allergy & Immunology Source Type: research

Efficacy and safety of five-day challenge for the evaluation of non-severe amoxicillin allergy in children
Conclusion Five-day challenge is a safe and effective way to rule out nonimmediate amoxicillin allergy, and it ensures a better compliance with future penicillin use.
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 7, 2018 Category: Allergy & Immunology Source Type: research

Efficacy and Safety of 5-Day Challenge for the Evaluation of Nonsevere Amoxicillin Allergy in Children
Conclusion The 5-day challenge is a safe and effective way to rule out nonimmediate amoxicillin allergy, and it ensures better compliance with future penicillin use.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 2, 2018 Category: Allergy & Immunology Source Type: research

Twenty years ’ experience with anaphylaxis-like reactions to local anesthetics: genuine allergy is rare
Conclusions Skin testing and provocative LA challenge are useful to exclude LA allergy, and this testing procedure seems to be appropriate to identify the extremely rare cases with IgE-mediated LA allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 13, 2018 Category: Allergy & Immunology Source Type: research

Efficacy and Safety of 5-Day Challenge for the Evaluation of Nonsevere Amoxicillin Allergy in Children
ConclusionThe 5-day challenge is a safe and effective way to rule out nonimmediate amoxicillin allergy, and it ensures better compliance with future penicillin use.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Controversies in Drug Allergy: Beta-Lactam Hypersensitivity Testing
Publication date: Available online 20 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Maria J. Torres, N. Franklin Adkinson, Jean-Christoph Caubet, David A. Khan, Mona I. Kidon, Louis Mendelson, Eva Rebelo Gomes, Ticha Rerkpattanapipat, Shuchen Zhang, Eric Macy, AAAAI/WAO 2018 Symposium Penicillin and Cephalosporin Allergy Testing Working GroupAll beta-lactam use is associated with a certain rate of adverse reactions. Many of these adverse reactions result in an allergy to the beta-lactam being entered into the patient's medical record. Unfortunately, only a small minority of the...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 21, 2018 Category: Allergy & Immunology Source Type: research

A Multicenter Evaluation of Diagnosis and Management of Omega-5 Gliadin Allergy (Also Known as Wheat-Dependent Exercise-Induced Anaphylaxis) in 132 Adults
ConclusionOmega-5 gliadin allergy is a rare wheat allergy that presents with severe anaphylaxis. The diagnosis is frequently delayed, and therefore we recommend that all adult patients presenting with anaphylaxis of unclear cause should have omega-5 gliadin specific IgE tested. A gluten-free diet or avoidance of wheat-based meals in combination with exercise (if the cofactor is exercise) helps to significantly decrease the risk of future allergic reactions. However, antihistamines and an epinephrine autoinjector must always be prescribed because one-third of patients continue to have allergic reactions despite dietary advice.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Diagnosing Peanut Allergy with Fewer Oral Food Challenges
Publication date: Available online 21 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jennifer J. Koplin, Kirsten P. Perrett, Hugh A. SampsonDiagnosis of peanut allergy presents a significant clinical challenge. Accurate diagnosis is critical for patient management and prevention of allergic reactions, whereas overdiagnosis or failure to diagnose tolerance in a previously allergic patient can lead to unnecessary dietary restrictions and impaired quality of life. Oral food challenges, the criterion standard for diagnosis, pose a risk of potentially severe allergic reactions, and ar...
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 21, 2018 Category: Allergy & Immunology Source Type: research

Lip dose challenges in food allergy: Current practice and diagnostic utility in the United Kingdom
ConclusionsThe majority of UK Allergy clinics included LDC as an initial step during OFC, despite a wide variation in how LDC are performed and interpreted, which raises major concerns about the reproducibility and the validity of the test. We found that LDC had poor sensitivity as an alternative or initial step to formal OFC.
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 10, 2019 Category: Allergy & Immunology Source Type: research

Electronic Consultations in Allergy/Immunology
ConclusionE-consults were increasingly used, particularly for historical adverse drug reactions and immunodeficiency. Implementation of an e-consult program resulted in decreased in-person wait times despite an increase in overall consult volume, supporting this model’s ability to provide expedited, problem-focused care.
Source: The Journal of Allergy and Clinical Immunology: In Practice - June 4, 2019 Category: Allergy & Immunology Source Type: research

Whole cell pertussis vaccination and decreased risk of IgE-mediated food allergy: a nested case-control study
ConclusionsAustralian infants who received wP vaccines were less likely to be diagnosed with food allergy in childhood than contemporaneous children who received aP vaccines. If a protective effect is confirmed in a randomised controlled trial, wP or mixed wP and aP vaccination schedules could form part of an effective strategy for combatting the rise in food allergies.
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 28, 2019 Category: Allergy & Immunology Source Type: research

Prevalence and Characteristics of Shellfish Allergy in the Pediatric Population of the United States
ConclusionThe epidemiology of SA in the US pediatric population shows crustacean allergy is more common than mollusk allergy. A disparity in SA children and epinephrine auto-injector carriage exists. Results from this study will lead to increased awareness of the need for detailed histories, specific diagnostic tests, and rescue epinephrine for anaphylaxis in US children with SA.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 7, 2020 Category: Allergy & Immunology Source Type: research