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Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research
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Total 69 results found since Jan 2013.
The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs)
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Jolanta Wiejak, Boy van Basten, Urszula Luchowska-Stańska, Graham Hamilton, Stephen J. YarwoodAbstractExchange protein activated by cyclic AMP (EPAC1) suppresses multiple inflammatory actions in vascular endothelial cells (VECs), partly due to its ability to induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene, the protein product of which inhibits interleukin 6 (IL6) signalling through the JAK/STAT3 pathway. Here, for the first time, we use the non-cyclic nucleotide EPAC1 ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - November 9, 2018 Category: Molecular Biology Source Type: research
Nuclear RXRα and RXRβ receptors exert distinct and opposite effects on RA-mediated neuroblastoma differentiation
Publication date: Available online 7 December 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Carolina Saibro Girardi, Diana Carolina Rostirolla, Fernanda Janini Mota Lini, Pedro Ozorio Brum, Jeferson Delgado, Camila Tiefensee Ribeiro, Alexsander Alves Teixeira, Daniel Oppermann Peixoto, Luana Heimfarth, Alice Kunzler, José Cláudio Fonseca Moreira, Daniel Pens GelainAbstractRetinoic acid (RA) promotes differentiation in multiple neurogenic cell types by promoting gene reprogramming through retinoid receptors and also by inducing cytosolic signaling events. The nuclear RXR receptors are...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 7, 2018 Category: Molecular Biology Source Type: research
Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells
In this study, we found that BLT2, a cell surface GPCR for leukotriene B4 and 12‑hydroxyeicosatetraenoic acid, is highly upregulated in KRAS mutant LOVO and SW480 colorectal cancer cells and plays critical roles in mediating proliferation through activation of phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt) and subsequent upregulation of cyclin D1. Exposure to BLT2 siRNA or LY255283, a specific BLT2 inhibitor, clearly suppressed the proliferation of KRAS mutant colorectal cancer cells and markedly increased cell cycle arrest by downregulating the PI3K/Akt-cyclin D1 cascade. Xenograft tumor formation by LOVO...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 14, 2018 Category: Molecular Biology Source Type: research
Role of AGAP2 in the profibrogenic effects induced by TGFβ in LX-2 hepatic stellate cells
Publication date: Available online 17 January 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Amaia Navarro-Corcuera, María J. López-Zabalza, Juan J. Martínez-Irujo, Gloria Álvarez-Sola, Matías A. Ávila, María J. Iraburu, Eduardo Ansorena, Cristina Montiel-DuarteAbstractLiver damage induces hepatic stellate cells (HSC) activation, characterised by a fibrogenic, proliferative and migratory phenotype. Activated HSC are mainly regulated by transforming growth factor β 1 (TGFβ1), which increases the production of extracellular matrix proteins (e.g. collagen-I) promoting the progress...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - January 18, 2019 Category: Molecular Biology Source Type: research
Elevated cyclic-AMP represses expression of exchange protein activated by cAMP (EPAC1) by inhibiting YAP-TEAD activity and HDAC-mediated histone deacetylation
Publication date: Available online 28 June 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Reza Ebrahimighaei, Madeleine C. McNeill, Sarah A. Smith, Jason P. Wray, Kerrie L. Ford, Andrew C. Newby, Mark BondAbstractLigand-induced activation of Exchange Protein Activated by cAMP-1 (EPAC1) is implicated in numerous physiological and pathological processes, including cardiac fibrosis where changes in EPAC1 expression have been detected. However, little is known about how EPAC1 expression is regulated. Therefore, we investigated regulation of EPAC1 expression by cAMP in cardiac fibroblasts.El...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 29, 2019 Category: Molecular Biology Source Type: research
Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry
In conclusion, we have demonstrated for the first time that the lysosomal cysteine protease, CTSS, plays an important role in mediating Ca2+ homeostasis by regulating STIM1 trafficking, which leads to the suppression of cell migration and invasion.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - July 21, 2019 Category: Molecular Biology Source Type: research
Aquaporin-1 plays a key role in erythropoietin-induced endothelial cell migration
Publication date: Available online 30 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Romina E. Maltaneri, Agustina Schiappacasse, María E. Chamorro, Alcira B. Nesse, Daniela C. VittoriAbstractWater influx through aquaporin-1 (AQP-1) has been linked to the ability of different cell types to migrate, and therefore plays an important part in processes like metastasis and angiogenesis. Since the erythroid growth factor erythropoietin (Epo) is now recognized as an angiogenesis promoter, we investigated the participation of AQP-1 as a downstream effector of this cytokine in the migra...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 31, 2019 Category: Molecular Biology Source Type: research
Neuropeptide bombesin receptor activation stimulates growth of lung cancer cells through HER3 with a MAPK-dependent mechanism
Publication date: Available online 17 December 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Lingaku Lee, Irene Ramos-Alvarez, Terry W. Moody, Samuel A. Mantey, Robert T. JensenAbstractDespite recent advances in treatment of non-small cell lung cancer (NSCLC), prognosis still remains poor and new therapeutic approaches are needed. Studies demonstrate the importance of the EGFR/HER-receptor family in NSCLC growth, as well as that of other tumors. Recently, HER3 is receiving increased attention because of its role in drug resistance and aggressive growth. Activation of overexpressed G-pr...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 18, 2019 Category: Molecular Biology Source Type: research
Roles of Id1/HIF-1 and CDK5/HIF-1 in cell cycle reentry induced by amyloid-beta peptide in post-mitotic cortical neuron
Publication date: Available online 26 December 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): A-Ching Chao, Chien-Hui Chen, Ming-Hsuan Wu, Bo-Yu Hou, Ding-I YangAbstractOne neurotoxic mechanism of amyloid-beta peptide (Aβ), the major component of senile plaques in the brains of Alzheimer's disease (AD) patients, is to trigger cell cycle reentry in fully differentiated neurons. However, the detailed underlying mechanisms remain unclear. Using Aβ25-35–treated primary rat cortical neurons as the experimental system, in the present study we tested whether Aβ-induced inhibitor of differ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 26, 2019 Category: Molecular Biology Source Type: research
