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Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research
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Total 69 results found since Jan 2013.
Mitochondrial function contributes to oxysterols-induced osteogenic differentiation in mouse embryonic stem cells
This study investigated the effect of an oxysterol combination of 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol (SS) on osteogenic differentiation of ESCs and the alterations to mitochondrial activity during differentiation. Osteogenic differentiation was assessed by alkaline phosphatase (ALP) activity, matrix mineralization, mRNA expression of osteogenic factors, runt-related transcription factor 2, osterix, and osteocalcin, and protein levels of collagen type IA (COLIA) and osteopontin (OPN). Treatment of cells with SS increased osteoinductive activity compared to the control group. Intracellular reactive oxygen ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 16, 2014 Category: Molecular Biology Source Type: research
Mitochondrial function contributes to oxysterol-induced osteogenic differentiation in mouse embryonic stem cells
This study investigated the effect of an oxysterol combination of 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol (SS) on osteogenic differentiation of ESCs and the alterations to mitochondrial activity during differentiation. Osteogenic differentiation was assessed by alkaline phosphatase (ALP) activity, matrix mineralization, mRNA expression of osteogenic factors, runt-related transcription factor 2, osterix, and osteocalcin, and protein levels of collagen type IA (COLIA) and osteopontin (OPN). Treatment of cells with SS increased osteoinductive activity compared to the control group. Intracellular reactive oxygen ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - January 24, 2015 Category: Molecular Biology Source Type: research
Nuclear envelope proteins Nesprin2 and LaminA regulate proliferation and apoptosis of vascular endothelial cells in response to shear stress
Publication date: Available online 23 February 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Yue Han , Lu Wang , Qing-Ping Yao , Ping Zhang , Bo Liu , Guo-Liang Wang , Bao-Rong Shen , Binbin Cheng , Yingxiao Wang , Zong-Lai Jiang , Ying-Xin Qi The dysfunction of vascular endothelial cells (ECs) influenced by flow shear stress is crucial for vascular remodeling. However, the roles of nuclear envelope (NE) proteins in shear stress-induced EC dysfunction are still unknown. Our results indicated that, compared with normal shear stress (NSS), low shear stress (LowSS) suppressed the expre...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - February 23, 2015 Category: Molecular Biology Source Type: research
Protein kinase CK2 potentiates translation efficiency by phosphorylating eIF3j at Ser127
Publication date: July 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1853, Issue 7 Author(s): Christian Borgo , Cinzia Franchin , Valentina Salizzato , Luca Cesaro , Giorgio Arrigoni , Laura Matricardi , Lorenzo A. Pinna , Arianna Donella-Deana In eukaryotic protein synthesis the translation initiation factor 3 (eIF3) is a key player in the recruitment and assembly of the translation initiation machinery. Mammalian eIF3 consists of 13 subunits, including the loosely associated eIF3j subunit that plays a stabilizing role in the eIF3 complex formation and interaction with the 40S ribosom...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 15, 2015 Category: Molecular Biology Source Type: research
Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons
In conclusion, our findings indicated that OSM induces Mcl-1 expression via activation of ERK1/2, JAK1/2, STAT1/3, and CREB; furthermore, OSM-mediated Mcl-1 induction contributes to bioenergetic improvements and neuroprotective effects against 3-NP toxicity in cortical neurons. OSM may thus serve as a novel neuroprotective agent against mitochondrial dysfunction commonly associated with pathogenic mechanisms underlying neurodegeneration.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 16, 2015 Category: Molecular Biology Source Type: research
Dominant negative Ras attenuates pathological ventricular remodeling in pressure overload cardiac hypertrophy
We examined the possible anti-hypertrophic effect of Ras inhibition in vitro using rat neonatal cardiomyocytes (NRCM) and in vivo in the setting of pressure-overload left ventricular (LV) hypertrophy (POH) in rats. Ras functions were modulated via adenovirus directed gene transfer of active mutant Ras-Val12 or dominant negative mutant N17-DN-Ras (DN-Ras). Ras-Val12 expression in vitro activates NFAT resulting in pro-hypertrophic and cardio-toxic effects on NRCM beating and Z-line organization. In contrast, the DN-Ras was antihypertrophic on NRCM, inhibited NFAT and exerted cardio-protective effects attested by preserved NR...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - September 4, 2015 Category: Molecular Biology Source Type: research
Mitochondrial DNA has a pro-inflammatory role in AMD
This study contributes to our understanding of the potential pro-inflammatory role of mtDNA in the pathogenesis of AMD. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - September 7, 2015 Category: Molecular Biology Source Type: research
Tensin1 positively regulates RhoA activity through its interaction with DLC1
Publication date: December 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1853, Issue 12 Author(s): Yi-Ping Shih, Peng Sun, Aifeng Wang, Su Hao Lo DLC1 is a RhoGAP-containing tumor suppressor and many of DLC1's functions are absolutely dependent on its RhoGAP activity. Through its RhoGAP domain, DLC1 inhibits the activity of RhoA GTPase, which regulates actin cytoskeleton networks and dis/assembly of focal adhesions. Tensin1 (TNS1) is a focal adhesion molecule that links the actin cytoskeleton to integrins and forms signaling complexes through its multiple binding domains. Here, we ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 4, 2015 Category: Molecular Biology Source Type: research
TRPV6 channel modulates proliferation of insulin secreting INS-1E beta cell line
In conclusion, this study demonstrates for the first time the expression of TRPV6 in INS-1E cells and rat pancreatic beta cells and describes its role in modulating calcium signaling, beta cell proliferation and insulin mRNA expression. In contrast, TRPV6 fails to influence insulin secretion.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 5, 2015 Category: Molecular Biology Source Type: research
Leukotriene B4 receptor-2 contributes to chemoresistance of SK-OV-3 ovarian cancer cells through activation of signal transducer and activator of transcription-3-linked cascade
In this study, we found that the low-affinity leukotriene B4 receptor-2 (BLT2) and its ligand leukotriene B4 were highly up-regulated in cisplatin-resistant SK-OV-3 ovarian cancer cells and play critical roles in mediating the chemoresistance through the activation of signal transducer and activator of transcription-3 (STAT-3) and the subsequent up-regulation of interleukin-6 (IL-6). BLT2 depletion with siRNA clearly abolished the chemoresistance to cisplatin in SK-OV-3 ovarian cancer cells and further increased cell sensitivity to cisplatin chemotherapy by down-regulating the ‘STAT-3-IL-6’ cascade. Enlarged tumor form...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - November 22, 2015 Category: Molecular Biology Source Type: research
Cross-talk between lysophosphatidic acid receptor 1 and tropomyosin receptor kinase a promotes lung epithelial cell migration
Publication date: Available online 17 November 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Ling Nan, Jianxin Wei, Anastasia M. Jacko, Miranda K. Culley, Jing Zhao, Viswanathan Natarajan, Haichun Ma, Yutong Zhao Lysophosphatidic acid (LPA) is a bioactive lysophospholipid, which plays a crucial role in regulation of cell proliferation, migration, and differentiation. LPA exerts its biological effects mainly through binding to cell-surface LPA receptors (LPA1-6), which belong to the G protein-coupled receptor (GPCR) family. Recent studies suggest that cross-talk between recep...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - November 22, 2015 Category: Molecular Biology Source Type: research
Activation of autophagy by globular adiponectin is required for muscle differentiation
Publication date: Available online 26 January 2016 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Tania Gamberi, Alessandra Modesti, Francesca Magherini, Donna M. D'Souza, Thomas Hawke, Tania Fiaschi Regulated autophagy is a critical component for a healthy skeletal muscle mass, such that dysregulation of the autophagic processes correlates with severe myopathies. Thus, defining the biological molecules involved in the autophagic processes within skeletal muscle is of great importance. Here we demonstrate that globular adiponectin (gAd) activates autophagy in skeletal muscle myoblas...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - January 29, 2016 Category: Molecular Biology Source Type: research
Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3
Conclusion Altogether the results are consistent with a model whereby both constitutive and ligand-induced internalization of ErbB3 are regulated through interaction with epsin 1. General significance Internalization is an important regulator of growth factor receptor mediated signaling and the current study identify mechanisms regulating plasma membrane turnover of ErbB3. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - March 11, 2016 Category: Molecular Biology Source Type: research
Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway
Publication date: Available online 8 April 2016 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Manjari Kundu, Barun Mahata, Avisek Banerjee, Sohini Chakraborty, Shibjyoti Debnath, Sougata Sinha Ray, Zhumur Ghosh, Kaushik Biswas The definitive role of ganglioside GM2 in mediating tumor-induced growth and progression is still unknown. Here we report a novel role of ganglioside GM2 in mediating tumor cell migration and uncovered its mechanism. Data shows differential expression levels of GM2-synthase as well as GM2 in different human cancer cells. siRNA mediated knockdown of GM2-synt...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 7, 2016 Category: Molecular Biology Source Type: research
Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes
Publication date: July 2016 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1863, Issue 7, Part A Author(s): Shruthi S. Bhat, Kim S. Friedmann, Arne Knörck, Cora Hoxha, Petra Leidinger, Christina Backes, Eckart Meese, Andreas Keller, Jens Rettig, Markus Hoth, Bin Qu, Eva C. Schwarz Cytotoxic T lymphocytes (CTL) eliminate pathogen-infected and cancerous cells mainly by polarized secretion of lytic granules (LG, containing cytotoxic molecules like perforin and granzymes) at the immunological synapse (IS). Members of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment pr...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 2, 2016 Category: Molecular Biology Source Type: research
