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The role of microRNAs in colorectal cancer
Publication date: December 2016 Source:Biomedicine & Pharmacotherapy, Volume 84 Author(s): Ali Mohammadi, Behzad Mansoori, Behzad Baradaran Colorectal cancer (CRC) is still the third most common cancer in the world. Mechanism of CRC tumorigenesis has been widely studied at the molecular levels, and has been recently entered the area of microRNAs. MicroRNAs are small 19 to 22 nucleotides of RNA that engage in the regulation of cell differentiation, apoptosis, and cell cycle progression. MicroRNAs are similar to small interfering RNA (siRNA), that post-transcriptionally regulate gene expression and control various c...
Source: Biomedicine and Pharmacotherapy - October 1, 2016 Category: Drugs & Pharmacology Source Type: research

Small-molecule GSK-3 inhibitor rescued apoptosis and neurodegeneration in anesthetics-injured dorsal root ganglion neurons
Conclusions GSK-3 inhibitor SB216763, through PKC, is effective in protecting anesthetics-induced neurotoxicity in DRG.
Source: Biomedicine and Pharmacotherapy - September 23, 2016 Category: Drugs & Pharmacology Source Type: research

Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling
Conclusion Curcumin induced apoptosis and G0/G1 arrest in DU-145 cells by down regulating Notch signaling.
Source: Biomedicine and Pharmacotherapy - September 19, 2016 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory activities of fenoterol through β-arrestin-2 and inhibition of AMPK and NF-κB activation in AICAR-induced THP-1 cells
In this study, we explored the mechanism of β2-AR stimulation with fenoterol in AICAR-induced inflammatory cytokine secretion in THP-1 cells. We studied AMPK activation using p-AMPK and AMPK antibodies, nuclear factor-kappa B (NF-κB) activation and inflammatory cytokine secretion in THP-1 cells stimulated by β2-AR in the presence or absence of AICAR and small interfering RNA (siRNA)-mediated knockdown of β-arrestin-2 or AMPKα1 subunit. AICAR-induced AMPK activation, NF-κB activation and tumor necrosis factor (TNF)-α release were reduced by fenoterol. In addition, siRNA-mediated knockdown of β-arrestin-2 abolished f...
Source: Biomedicine and Pharmacotherapy - September 19, 2016 Category: Drugs & Pharmacology Source Type: research

BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes
Conclusion Our results indicated that BACH1 down-regulation in HT29 CRC cells had no effect on cell growth but did inhibit cell migration by decreasing metastasis-related genes expression. Collectively, these results suggest that BACH1 may function as an oncogenic driver in colon cancer and may represent as a potential target of gene therapy for CRC treatment.
Source: Biomedicine and Pharmacotherapy - September 19, 2016 Category: Drugs & Pharmacology Source Type: research

miR-135b reverses chemoresistance of non-small cell lung cancer cells by downregulation of FZD1
Conclusion The amplification of miR-135b suppressed NSCLC chemoresistance by directly mediating the FZD1 downregulation.
Source: Biomedicine and Pharmacotherapy - September 17, 2016 Category: Drugs & Pharmacology Source Type: research

Co-delivery of IL17RB siRNA and doxorubicin by chitosan-based nanoparticles for enhanced anticancer efficacy in breast cancer cells
In conclusion, co-delivery of IL17RB siRNA and DOX can be considered as an effective system for the treatment of breast cancer.
Source: Biomedicine and Pharmacotherapy - June 30, 2016 Category: Drugs & Pharmacology Source Type: research

Up-regulated microRNA-155 expression is associated with poor prognosis in cervical cancer patients
Conclusion Our study presents that miR-155 is a novel molecule involved in cervical cancer progression, which provide a potential prognostic biomarker and therapeutic target.
Source: Biomedicine and Pharmacotherapy - June 28, 2016 Category: Drugs & Pharmacology Source Type: research

IRE1α-TRAF2-ASK1 pathway is involved in CSTMP-induced apoptosis and ER stress in human non-small cell lung cancer A549 cells
Conclusions Collectively, we showed that CSTMP induced apoptosis of A549 cells were through IRE1α-TRAF2-ASK1 complex-mediated ER stress, JNK activation, and mitochondrial dysfunction. These insights on this novel compound CSTMP may provide a novel anti-cancer candidate for the treatment of NSCLC.
Source: Biomedicine and Pharmacotherapy - May 17, 2016 Category: Drugs & Pharmacology Source Type: research

LATS2 as a poor prognostic marker regulates non-small cell lung cancer invasion by modulating MMPs expression
In conclusion, low expression of LATS2 is a potential unfavorable prognostic factor and promoted cell invasion and migration in NSCLC.
Source: Biomedicine and Pharmacotherapy - May 17, 2016 Category: Drugs & Pharmacology Source Type: research

Inhibition of long non-coding RNA IGF2AS has profound effect on inducing neuronal growth and protecting local-anesthetic induced neurotoxicity in dorsal root ganglion neurons
Conclusions Inhibiting endogenous IGF2AS may promote neuronal growth and protect local-anesthetic induced neurotoxicity in DRG neurons, possibly through complimentary IGF2 upregulation and autocrine activation neurotrophin genes.
Source: Biomedicine and Pharmacotherapy - May 17, 2016 Category: Drugs & Pharmacology Source Type: research

Lipopolysaccharide potentiates endothelin-1-induced proliferation of pulmonary arterial smooth muscle cells by upregulating TRPC channels
Publication date: August 2016 Source:Biomedicine & Pharmacotherapy, Volume 82 Author(s): Hong-Ni Jiang, Bo Zeng, Gui-Lan Chen, Bin Lai, Shao-Hua Lu, Jie-Ming Qu Lipopolysaccharide (LPS) and endothelin-1 (ET-1) are critical pathogenic factors in sepsis-induced pulmonary hypertension; however it is unknown whether they have a coordinated action in the pathogenesis of this disease. Here we found that although LPS did not change the contractility of rat pulmonary arterial smooth muscle cells (PASMCs) in response to ET-1, it significantly promoted ET-1-induced PASMC proliferation. Measurement of ET-1-evoked Ca2+...
Source: Biomedicine and Pharmacotherapy - May 3, 2016 Category: Drugs & Pharmacology Source Type: research

MiR-125a regulates ovarian cancer proliferation and invasion by repressing GALNT14 expression
In this study, western blotting, immunohistochemistry and serum-ELISA assay revealed that polypeptide N-acetylgalactosaminyl transferase 14 (GALNT14) expression was upregulated and correlated with the cancer stage in ovarian cancer. The expression levels of miR-125a were downregulated and negatively related to GALNT14 expression in clinical ovarian cancer tissues. Moreover, luciferase reporter assay identified polypeptide N-acetylgalactosaminyl transferase 14 (GALNT14) as a direct target of miR-125a, and overexpression of miR-125a markedly reduced the expression of GALNT14 in ovarian cancer. Functional characterization of ...
Source: Biomedicine and Pharmacotherapy - April 7, 2016 Category: Drugs & Pharmacology Source Type: research

Procyanidins, from Castanea mollissima Bl. shell, induces autophagy following apoptosis associated with PI3K/AKT/mTOR inhibition in HepG2 cells
Publication date: July 2016 Source:Biomedicine & Pharmacotherapy, Volume 81 Author(s): Haihui Zhang, Xiaoping Luo, Jiajia Ke, Yuqing Duan, Yuanqing He, Di Zhang, Meihong Cai, Guibo Sun, Xiaobo Sun Procyanidins from Castanea mollissima Bl. shell (CSPCs) induced autophagy and apoptosis in HepG2 cells and its mechanism remains to be examined. In this paper, autophagy was measured by the lipid modification of light chain-3 (LC3) and the formation of autophagosomes. Hoechst 33258 staining and flow cytometer analysis were used to measure apoptosis. The western blot analysis was used to examine the effects of C...
Source: Biomedicine and Pharmacotherapy - April 6, 2016 Category: Drugs & Pharmacology Source Type: research

Long noncoding RNA BDNF-AS protects local anesthetic induced neurotoxicity in dorsal root ganglion neurons
Conclusions BDNF-AS downregulation rescued local anesthetic-induce neurotoxicity in DRG neurons, probably through the activation of neurotrophin TrkB signaling pathway.
Source: Biomedicine and Pharmacotherapy - March 28, 2016 Category: Drugs & Pharmacology Source Type: research

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