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Inhibition of autophagy enhances the anticancer effect of enzalutamide on bladder cancer
ConclusionsAutophagy may be a potential mechanism underlying ENZ-resistant bladder cancer. Blockade of autophagy significantly increased ENZ-induced apoptosis in bladder cancer. Thus, concurrent treatment with autophagy inhibitors and ENZ may be a novel therapeutic strategy for bladder cancer.Graphical abstract
Source: Biomedicine and Pharmacotherapy - September 28, 2019 Category: Drugs & Pharmacology Source Type: research

The mechanism of SP1/p300 complex promotes proliferation of multiple myeloma cells through regulating IQGAP1 transcription
Publication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Zhouxiang Jin, Shujuan Zhou, Haige Ye, Songfu Jiang, Kang Yu, Yongyong MaAbstractOur previous research had firstly shown that MM cells overexpressed IQGAP1 gene and activated Ras/Raf/MEK/ERK pathway. But the mechanism of IQGAP1 overexpression and IQGAP1 gene transcription regulation remains uncertain. The mechanism of IQGAP1 overexpression and transcriptional regulation of IQGAP1 gene in myeloma cells was explored in the study. Through bioinformatics analysis and prediction we predicted and screened transcription factor Sp1 as a poss...
Source: Biomedicine and Pharmacotherapy - September 17, 2019 Category: Drugs & Pharmacology Source Type: research

Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Jing-Ze Yu, Yi Ying, Yang Liu, Chun-Bin Sun, Chen Dai, Shan Zhao, Shou-Zheng Tian, Jing Peng, Ni-Ping Han, Jia-Li Yuan, Jin-Yuan Yan, Zhong-Shan YangAbstractPulmonary fibrosis (PF) is a crippling disease characterized by progressive dyspnea and associated with a high mortality rate, but its origin is unknown and there is no effective treatment. Yifei Sanjie formula (YFSJF) is a Chinese medicine that is widely used for treatment of respiratory systems disease. However, the molecular basis for the function of YFSJF has not been determin...
Source: Biomedicine and Pharmacotherapy - August 9, 2019 Category: Drugs & Pharmacology Source Type: research

Desmoglein 3 gene mediates epidermal growth factor/epidermal growth factor receptor signaling pathway involved in inflammatory response and immune function of anaphylactic rhinitis
ConclusionSilencing DSG3 gene can inhibit the activation of EGF signaling pathway, alleviate the inflammation of AR nasal mucosa, and enhance red blood cells immune adherence function.Graphical abstract
Source: Biomedicine and Pharmacotherapy - August 3, 2019 Category: Drugs & Pharmacology Source Type: research

Astragalus polysaccharide ameliorates lipopolysaccharide-induced cell injury in ATDC5 cells via miR-92a/KLF4 mediation
ConclusionsThe present study reveals that APS protects ATDC5 cells against LPS induced-injury by regulation of miR-92a/KLF4 axis and suppressing NF-κB and p38MAPK signal pathways.Graphical abstract
Source: Biomedicine and Pharmacotherapy - July 12, 2019 Category: Drugs & Pharmacology Source Type: research

The oncogenic role of CB2 in the progression of non-small-cell lung cancer
ConclusionOur data suggested that targeting CB2 may inhibit the growth and survival of NSCLC cells, which the Akt/mTOR/P70S6K pathway may be involved in. These results confer the pro-oncogenic role of CB2 in the progression of NSCLC, thus improving our understanding of CB2 in tumor progression.
Source: Biomedicine and Pharmacotherapy - June 7, 2019 Category: Drugs & Pharmacology Source Type: research

Magnesium isoglycyrrhizinate ameliorates radiation-induced pulmonary fibrosis by inhibiting fibroblast differentiation via the p38MAPK/Akt/Nox4 pathway
Publication date: July 2019Source: Biomedicine & Pharmacotherapy, Volume 115Author(s): Qunfang Yang, Pan Zhang, Tao Liu, Xuan Zhang, Xichun Pan, Yanyan Cen, Ya Liu, Haigang Zhang, Xiaohong ChenAbstractRadiation-induced pulmonary fibrosis (RIPF) is a severe complication in patients treated with thoracic irradiation. Until now, there are no effective therapeutic drugs for RIPF. In the present study, we attempted to evaluate the effect of Magnesium isoglycyrrhizinate (MgIG) on RIPF, and to further explore the underlying mechanisms. We found that MgIG treatment markedly improved radiation-induced lung pathological changes, red...
Source: Biomedicine and Pharmacotherapy - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling
Publication date: August 2019Source: Biomedicine & Pharmacotherapy, Volume 116Author(s): Yu Li, Haibo Zuo, Hongjian Wang, Anxiang HuAbstractHepatocellular carcinoma (HCC) results in large amounts of deaths each year worldwide. To develop more effective treatments for HCC, it is very necessary to define the molecular mechanisms in hepatocarcinogenesis. Mixed lineage kinase (MLK)-4 is a member of the MLK family of mitogen-activated protein kinase kinase kinases, and modulates different cellular responses. However, its role in the meditation of HCC progression remains unclear. In the study, we found that MLK4 was over-express...
Source: Biomedicine and Pharmacotherapy - May 6, 2019 Category: Drugs & Pharmacology Source Type: research

Involvement of miR-665 in protection effect of dexmedetomidine against Oxidative Stress Injury in myocardial cells via CB2 and CK1
ConclusionsDex precondition confers hearts protective effect against I/R injury by down-regulating expression of miR-665 and up-regulating expression of AK1 and Cnr2.
Source: Biomedicine and Pharmacotherapy - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-tumor effect of LATS2 on liver cancer death: Role of DRP1-mediated mitochondrial division and the Wnt/β-catenin pathway
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Lijuan Zhang, Shuping Li, Rong Wang, Changyuan Chen, Wen Ma, Hongyi CaiAbstractLarge tumor suppressor 2 (LATS2), an important mediator of the cell apoptotic response pathway, has been linked to the progression of several cancers. Here, we described the molecular feature of LATS2 as a novel antitumor factor in liver cancer cells in vitro. Western blotting was used to detect the expression of LATS2 and its downstream factors. ELISA, immunofluorescence, and flow cytometry were used to evaluate the alterations of mitochondrial function in re...
Source: Biomedicine and Pharmacotherapy - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Yap-Hippo promotes A549 lung cancer cell death via modulating MIEF1-related mitochondrial stress and activating JNK pathway
Publication date: May 2019Source: Biomedicine & Pharmacotherapy, Volume 113Author(s): Jiayu Zhou, Shizhen Zhang, Zhijun Li, Zhoumiao Chen, Yong Xu, Weiwen Ye, Zhengfu HeAbstractAlthough the role of Yes-associated protein (Yap) has been described in the progression of lung cancer, the downstream effector of the Yap-Hippo pathway has not been identified. Accordingly, the aim of our study is to explore whether Yap modulates the activity of lung cancer by controlling mitochondrial elongation factor 1 (MIEF1)-related mitochondrial stress in a manner dependent on the JNK pathway. Cell viability was determined via MTT, LDH releas...
Source: Biomedicine and Pharmacotherapy - March 13, 2019 Category: Drugs & Pharmacology Source Type: research

MicroRNA-370 protects against myocardial ischemia/reperfusion injury in mice following sevoflurane anesthetic preconditioning through PLIN5-dependent PPAR signaling pathway
This study aims to investigate the effects of microRNA (miR-370) targeting perilipin-5 (PLIN5) in mice following sevoflurane anesthetic preconditioning (SAP). A mouse model of left ventricular myocardial IRI was established, followed by the evaluation of myocardial infarction size and cardiac function to determine the effects of SAP. The underlying regulatory mechanisms of miR-370 were analyzed in concert with the treatment of miR-370 mimic, miR-370 inhibitor, or siRNA against PLIN5 in cardiomyocytes isolated from mice with IRI. Also, cardiomyocyte proliferation, cell cycle distribution and apoptosis were evaluated followi...
Source: Biomedicine and Pharmacotherapy - March 9, 2019 Category: Drugs & Pharmacology Source Type: research

SUMO protease SENP1 acts as a ceRNA for TGFBR2 and thus activates TGFBR2/Smad signaling responsible for LPS-induced sepsis
This study aims to explore the roles and related mechanisms of SUMO protease SENP1 in sepsis. Here, RNA-sequencing assay showed that SENP1 was significantly increased in human umbilical vein endothelial cells (HUVECs) with LPS treatment. Gene set enrichment analysis (GSEA) of RNA-sequencing dataset revealed that a positive enrichment of inflammation signatures was observed in HUVECs with SENP1 3′UTR overexpression. Further functional annotation analysis revealed that SENP1 3′UTR overexpression was positively correlated with TGFBR2 signaling pathway. Mechanistically, TGFBR2 was identified as a ceRNA (competing endogenou...
Source: Biomedicine and Pharmacotherapy - February 21, 2019 Category: Drugs & Pharmacology Source Type: research

ProNGF siRNA inhibits cell proliferation and invasion of pancreatic cancer cells and promotes anoikis
ConclusionProNGF expression is elevated in PDAC tissues and cell lines, and proNGF siRNA can inhibit cell proliferation, migration, and invasion, and promote anoikis of pancreatic cancer cells, in which decreased proNGF may participate.
Source: Biomedicine and Pharmacotherapy - January 11, 2019 Category: Drugs & Pharmacology Source Type: research

Lycium barbarum polysaccharide reduces hyperoxic acute lung injury in mice through Nrf2 pathway
ConclusionsLBP improves hyperoxic ALI via Nrf2-dependent manner. The LBP-induced activation of Nrf2 is mediated, at least in part, by AMPK pathway.
Source: Biomedicine and Pharmacotherapy - January 4, 2019 Category: Drugs & Pharmacology Source Type: research

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