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Source: GEO: Gene Expression Omnibus
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Total 772 results found since Jan 2013.
GSE128935 Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans
Contributors : Moran C Berkman ; Shani B Hemo ; Alla Fishman ; Hiba W Ben-Asher ; Ayelet T Lamm ; Sivan Henis-KorenblitSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism :How lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the control of gene expression. However, in contrast to miRNAs, the role of endo-siRNAs in aging remains unexplored. Here, by combining deep sequencing and genomic and genetic approaches in C.CaenorhabditisC. elegans elegans, we reveal an unprecedented role for endo-siRNA m...
Source: GEO: Gene Expression Omnibus - April 3, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Source Type: research
GSE143746 Arabidopsis thaliana small RNA from epidermis and vasculature tissues of Col-0 and ago1 mutants leaves
Contributors : Emanuel A Devers ; Christopher A Brosnan ; Alexis Sarazin ; Daniele Albertini ; Andrea C Amsler ; Florian Brioudes ; Pauline E Jullien ; Peiqi Lim ; Gregory Schott ; Olivier VoinnetSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Arabidopsis thalianaWe aimed at characterizing the identity of the silencing signal i.e. siRNA or longer dsRNA precursor thereof. We used transgenic dsRNA, endogenous dsRNA or virus infection as sources of siRNAs combined to sophisticated immunoprecipitation-based procedures coupled to deep-sequencing. We found that although they are diluted as they mov...
Source: GEO: Gene Expression Omnibus - April 6, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE112929 Movement of Arabidopsis thaliana inverted repeat small RNA between leaves vascular and epidermis tissues
Contributors : Emanuel A Devers ; Christopher A Brosnan ; Alexis Sarazin ; Daniele Albertini ; Andrea C Amsler ; Florian Brioudes ; Pauline E Jullien ; Peiqi Lim ; Gregory Schott ; Olivier VoinnetSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Arabidopsis thalianaWe aimed at characterizing the identity of the silencing signal i.e. siRNA or longer dsRNA precursor thereof. We used transgenic dsRNA, endogenous dsRNA or virus infection as sources of siRNAs combined to sophisticated immunoprecipitation-based procedures coupled to deep-sequencing...
Source: GEO: Gene Expression Omnibus - April 6, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE112885 small RNA sequences from grafted Arabidopsis thaliana expressing SucSUL inverted repeat
Contributors : Emanuel A Devers ; Christopher A Brosnan ; Alexis Sarazin ; Daniele Albertini ; Andrea C Amsler ; Florian Brioudes ; Pauline E Jullien ; Peiqi Lim ; Gregory Schott ; Olivier VoinnetSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Arabidopsis thalianaWe aimed at characterizing the identity of the silencing signal i.e. siRNA or longer dsRNA precursor thereof. We used transgenic dsRNA, endogenous dsRNA or virus infection as sources of siRNAs combined to sophisticated immunoprecipitation-based procedures coupled to deep-sequencing. We found that siRNAs populations are highly similar...
Source: GEO: Gene Expression Omnibus - April 6, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE134803 Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple negative breast cancer progression
Conclusions: Genes with 2-fold changes (absolute Log2 FC ≥ 1) in down- or up-regulation were selected in BT549 (311 down / 495 up), Hs578T (133 down / 117 up) and SUM149PT (500 down / 401 up) cells, respectively. Consequently, 95 DEGs were downregulated, and 79 DEGs upregulated in ≥ 2/3 of the TNBC cell lines, in total 174 DEGs, which were considered as common DEGs that were susceptible to the depletion of the amplification-dependent ASAP1. 53 of these commonly differentially expressed transcripts were linked to relapse-free survival in TNBC patients.
Source: GEO: Gene Expression Omnibus - May 19, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE143548 Xrn1p Acts at Multiple Steps in the Budding-Yeast RNAi Pathway to Enhance the Efficiency of Silencing
Contributors : Matthew A Getz ; David P BartelSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Naumovozyma castelliiRNA interference (RNAi) is a gene-silencing pathway that can play roles in viral defense, transposon silencing, heterochromatin formation, and post-transcriptional gene silencing. Although absent from Saccharomyces cerevisiae, RNAi is present in other budding-yeast species, including Naumovozyma castellii, which have an unusual Dicer and a conventional Argonaute that are both required for gene silencing. To identify other factors that act in the budding-yeast pathway, we perf...
Source: GEO: Gene Expression Omnibus - May 20, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Naumovozyma castellii Source Type: research
GSE142017 Dysregulation of MITF in the context of defective MC1R and RB1/p16/CDK4 leads to melanocyte transformation RNA-Seq
Contributor : Alfonso UrbanucciSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNAseq Expression analysis of immortalized melanocytes Hermes 3c (3C) and Hermes 4c (4C) cell lines following siRNA transfection with a control scrambled siRNA or an RNA targeting MITF
Source: GEO: Gene Expression Omnibus - July 2, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE101850 Sorafenib resistance related circRNAs
Contributors : Xiujun Cai ; Junjie XuSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensSorafenib resistance up-regulated circRNA_104797 could be transmitted by exosomes and responsible for the spread of Sorafenib resistance among HCC cells. CircRNA_104797 was critical for Sorafenib resistance maintenance and silencing circRNA_104797 could substantially increase the efficacy of Sorafenib by inducing apoptosis. Mechanism dissection unveiled that circRNA_104797 could specifically sponge miR-103a-2-5p and miR-660-3p and act as a competing endogenous RNA (ceRNA), thus competitively activated wnt/ β-catenin ...
Source: GEO: Gene Expression Omnibus - July 25, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
GSE157608 Cytoplasmic mRNA and Heavy polysome-associated mRNAs from U251 Cells treated with Control or eIF3e siRNAs
Contributors : Julie Sesen ; Anne Cammas ; Nicolas Skuli ; Stefania MillevoiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTranscriptional profiling of Cytoplasmic mRNA and Heavy polysome-associated mRNAs extracted from U251 Cells treated with control siRNA or siRNA targeting eIF3e . Goal was to determine the effect of eIF3e knockdown on translation of specific mRNAs.
Source: GEO: Gene Expression Omnibus - September 9, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE138022 lncRNA lncMGPF contributes to the genome-wide expression during myogenic differentiation
Contributors : B Zuo ; J JunSeries Type : Expression profiling by arrayOrganism : Mus musculusIn order to screen the target genes regulated by lncMGPF,we transfected the siRNA to knock down lncMGPF gene (si-lncMGPF) and negative control siRNA (si-NC), induced cells to differentiate for 2 days.
Source: GEO: Gene Expression Omnibus - September 30, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
GSE160001 FOXA1-dependent responses of the HER2+ SKBR-3 cell line to lapatinib
Contributors : Gary L Johnson ; Steven P AngusSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSKBR-3 HER2+ breast cancer cells were treated with 25 nM Dharmacon siGENOME non-targeting (NT) siRNA control pool or siRNA pool targeting FOXA1 for 48h, then treated with either DMSO or 300nM lapatinib for 24h.
Source: GEO: Gene Expression Omnibus - October 26, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE163042 Hepatocyte Host Factor IFI44L Regulates the Innate and Acquired Immune Responses to Hepatitis B Virus
Contributors : Takuto Nosaka ; Tatsushi Naito ; Hidetaka Matsuda ; Masahiro Ohtani ; Katsushi Hiramatsu ; Tsutomu Nishizawa ; Hiroaki Okamoto ; Yasunari NakamotoSeries Type : Expression profiling by arrayOrganism : Homo sapiensObjective: Curing hepatitis B requires the complete elimination of covalently closed circular DNA (cccDNA). Interferon (IFN)- γ is produced by cytotoxic T lymphocytes and has noncytolytic antiviral potential; however, elimination of cccDNA could not be achieved. To enhance the regulatory effect of IFN-γ, we comprehensively analyzed the host factors that associated with cccDNA amplification and IFN-...
Source: GEO: Gene Expression Omnibus - December 12, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE167197 Peroxisome import stress induces eIF2 α phosphorylation and impairs ribosome biogenesis
Contributors : Kerui Huang ; Jinoh Kim ; Pham Vo ; Ting Miao ; Mirre J Simons ; Hua BaiSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogaster ; Homo sapiensPeroxisome biogenesis diseases (PBDs) are characterized by global defects in peroxisomal function and can result in severe brain, liver, kidney, and bone malfunctions. PBDs are due to mutations in peroxisome biogenesis factors (PEX genes) that are responsible for peroxisome assembly and function. Increasing evidence suggests that peroxisome import functions decline during aging. However, the transcriptome profiling of peroxiso...
Source: GEO: Gene Expression Omnibus - February 23, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Homo sapiens Source Type: research
GSE138991 Caveolin1 Deficiency: A Type I Endothelial Interferonopathy Associated with Pulmonary Arterial Hypertension
Contributors : Salina Gairhe ; Gabriela A Ferreyra ; Jason M Elinoff ; Cumhur Y Demirkale ; Robert L DannerSeries Type : Expression profiling by arrayOrganism : Homo sapiensCAV1 loss-of-function mutations have been associated with the development of pulmonary arterial hypertension (PAH). CAV1 is an integral component of endothelial caveolae, specialized lipid rafts that attach to the actin cytoskeleton and modulate receptor/signal transduction coupling. CAV1 loss in pulmonary artery endothelial cells produced a proliferative, hypermigratory cellular phenotype with a disrupted cytoskeletal architecture, mirroring known feat...
Source: GEO: Gene Expression Omnibus - February 24, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE163164 Gene expression profiling of AGS Gastric Cancer cells upon YY1 knock down
Contributors : B DIVYA ; G KUMARESANSeries Type : Expression profiling by arrayOrganism : Homo sapiensYin Yang 1 (YY1) is a ubiquitous transcription factor belonging to the GLI-Kruppel class of zinc finger proteins regulating diverse biological processes including cell proliferation, development, DNA damage responses and also involved in carcinogenesis. The protein is involved in repressing and activating a diverse number of promoters.In order to study the role of the transcription factor YY1 in gastric cancer, transcriptome wide gene expression analysis was performed upon silencing the YY1 gene in gastric cancer cell line...
Source: GEO: Gene Expression Omnibus - March 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
