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Source: Clinical and Translational Allergy

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Total 373 results found since Jan 2013.

Antigen-induced airway hyperresponsiveness and obstruction is related to caveolin-1 expression in airway smooth muscle in a guinea pig asthma model
Conclusions Our data suggest that caveolin-1 expression in ASM has a crucial role in the development of antigen-induced airway obstruction and hyperresponsiveness in a guinea pig asthma model. In addition, the asthma model in guinea pigs appears to induce a contractile smooth muscle phenotype in the airways and a proliferative smooth muscle phenotype in pulmonary vessels.
Source: Clinical and Translational Allergy - March 26, 2015 Category: Allergy & Immunology Source Type: research

Prolonged efficacy of the 300IR 5-grass pollen tablet up to 2 years after treatment cessation, as measured by a recommended daily combined score
Conclusions In adults with grass pollen-associated ARC, 5-grass pollen tablet therapy beginning 4 months before the pollen season and continuing to season’s end demonstrated efficacy across all variables during active treatment, and this effect was prolonged for up to 2 years post-treatment. Trial registration ClinicalTrials.gov identifier: NCT00418379.
Source: Clinical and Translational Allergy - May 22, 2015 Category: Allergy & Immunology Source Type: research

Innate lymphocyte cells in asthma phenotypes
Abstract T helper type 2 (TH2) cells were previously thought to be the main initiating effector cell type in asthma; however, exaggerated TH2 cell activities alone were insufficient to explain all aspects of asthma. Asthma is a heterogeneous syndrome comprising different phenotypes that are characterized by their different clinical features, treatment responses, and inflammation patterns. The most-studied subgroups of asthma include TH2-associated early-onset allergic asthma, late-onset persistent eosinophilic asthma, virus-induced asthma, obesity-related asthma, and neutrophilic asthma. The recent discovery of h...
Source: Clinical and Translational Allergy - July 6, 2015 Category: Allergy & Immunology Source Type: research

Self-reported adverse reactions and IgE sensitization to common foods in adults with asthma
Conclusions The prevalence of self-reported adverse reactions and sensitization to the most common foods was much higher among the asthmatic subjects. Hazelnut was the food that asthmatics most frequently experienced adverse reactions from, and the strong correlation between IgE to hazelnut and birch indicate that the observed adverse reactions are partly due to sensitization to allergens from the PR-10 family.
Source: Clinical and Translational Allergy - July 17, 2015 Category: Allergy & Immunology Source Type: research

Cough hypersensitivity as a neuro-immune interaction
Abstract Cough is an intrinsic protective reflex. However, chronic cough affects a considerable proportion of general population and has a major impact on quality of life. A recent paradigm shift to ‘cough hypersensitivity syndrome’ suggests that chronic cough arises from hypersensitivity of the airway sensory nerves. As cough reflex is determined by interaction of the nervous system with immune system, persistent dysregulation of one or both of these systems may lead to chronic cough hypersensitivity. Here we review the current evidence for the neuro-immune interactions that underlie cough hypersensitivity a...
Source: Clinical and Translational Allergy - July 15, 2015 Category: Allergy & Immunology Source Type: research

Exploratory study of tolerability and immunological effect of a short up-dosing immunotherapy phase with a standardised allergen extract derived from pollen of Olea europaea
Conclusion This new SCIT derived from pollen of Olea europaea presented a good tolerability profile and induced significant immunological responses already after a 6 week treatment. However, the non-controlled design may limit the interpretation of these results. Trial registration EudraCT no: 2011-004852-20; ClinicalTrials.gov Identifier: NCT01674595.
Source: Clinical and Translational Allergy - July 24, 2015 Category: Allergy & Immunology Source Type: research

ASSURE-CSU: a real-world study of burden of disease in patients with symptomatic chronic spontaneous urticaria
Discussion ASSURE-CSU will be the first study to examine the economic and humanistic burden of disease in patients diagnosed with CSU/CIU who are symptomatic despite treatment. By combining retrospective evaluation of medical records with prospective patient surveys and 8-day diaries, across seven different countries, the ASSURE-CSU study will contribute to a better understanding and acknowledgement of the burden of disease in patients with symptomatic chronic spontaneous urticaria.
Source: Clinical and Translational Allergy - August 17, 2015 Category: Allergy & Immunology Source Type: research

Immunological events in chronic spontaneous urticaria
Abstract Chronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features. We have made significant progress in several aspects relating to this condition. However, the exact physiopathology remains unknown. There is mounting evidence for an autoimmune basis, demonstrated by the CSU serum ability to activate healthy donors skin mast cells and blood basophils. However, it is only seen among 35–40% of patients. Mast cells and basophils play an important role in this skin condition. Both cells in CSU patients have unique features that differentiate them from basophils and...
Source: Clinical and Translational Allergy - August 25, 2015 Category: Allergy & Immunology Source Type: research

Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back
Abstract Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a considerable burden of morbidity and mortality not only driven by the reactions themselves but also by the use of alternatives which are sometimes less effective or even more dangerous. Diagnostic procedures rely on clinical history, skin testing and potential provocation testing, whereas validated in vitro diagnostic procedures are still lacking for most of them. Recen...
Source: Clinical and Translational Allergy - September 3, 2015 Category: Allergy & Immunology Source Type: research

Erratum to: Innate lymphoid cells in asthma phenotypes
Source: Clinical and Translational Allergy - September 15, 2015 Category: Allergy & Immunology Source Type: research

Treatment of acute rhinitis with a nasal spray containing tramazoline and essential oils: a multicenter, uncontrolled, observational trial
Conclusions Community-based patients reported a relief in acute rhinitis symptoms and improvement in quality of life as a result of treatment with Rhinospray® Plus. Treatment was well-tolerated.
Source: Clinical and Translational Allergy - November 4, 2015 Category: Allergy & Immunology Source Type: research

Interchangeability and comparative effectiveness between generic and brand montelukast immediate release tablets after a single oral administration in healthy volunteers
Conclusion Broncast® immediate release film coated tablets (10 mg/tablet) are bioequivalent to Singulair® immediate release film coated tablets (10 mg/tablet), with a comparable safety and efficacy profile. This suggests that these two formulations can be clinically considered interchangeable. The dissolution study suggests that it could be used as premarketing quality control parameter in order to maintain the high quality of the produced product.
Source: Clinical and Translational Allergy - November 11, 2015 Category: Allergy & Immunology Source Type: research

Treating chronic spontaneous urticaria using a brief ‘whole person’ treatment approach: a proof-of-concept study
Conclusions A clinician treating chronic spontaneous urticaria in an Immunology department, using a whole person treatment paradigm, can safely explore unique meanings and emotional states, in a process acceptable to patients, resulting in a significant clinical benefit for symptoms. A much larger study comparing the outcome of WPTA versus standard treatment alone is warranted.
Source: Clinical and Translational Allergy - December 2, 2015 Category: Allergy & Immunology Source Type: research

Chronic rhinosinusitis in adolescence is a rare but bothersome condition - data from a Swedish population based cohort
Source: Clinical and Translational Allergy - June 26, 2015 Category: Allergy & Immunology Source Type: research

A role for neuropeptides in innate immune inflammation of the nose
Source: Clinical and Translational Allergy - June 26, 2015 Category: Allergy & Immunology Source Type: research