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Source: Current Treatment Options in Allergy

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Total 345 results found since Jan 2013.

Duration of Allergen Immunotherapy for Long-Term Efficacy in Allergic Rhinoconjunctivitis
AbstractRationaleSubcutaneous and sublingual immunotherapy are effective for allergic rhinitis. An important question is whether allergen immunotherapy provides a sustained clinical effect after treatment cessation. In view of potential side effects, cost and the necessary patient commitment, long-term benefit is an important consideration for the recommendation of immunotherapy over standard pharmacotherapy.Purpose of reviewIn this review, we analyse the existing evidence for long-term effects of both routes of administration in the context of double-blind, placebo-controlled, randomised clinical trials that included a fo...
Source: Current Treatment Options in Allergy - August 31, 2018 Category: Allergy & Immunology Source Type: research

What Do We Really Know About Intralymphatic Immunotherapy?
AbstractPurpose of reviewAllergen-specific immunotherapy (AIT) is the only causal treatment method of IgE-mediated allergies that may lead to long-term symptom amelioration even after the end of treatment, positively interfere with the course of disease, and improve the immunological situation of the patient. While AIT in general requires treatment periods over 3 up to 5  years, intralymphatic immunotherapy (ILIT) needs only three ultrasound-guided injections of low allergen doses into inguinal lymph nodes with 4-week time interval making the entire treatment possible within 2 months.Recent findingsThe number of publishe...
Source: Current Treatment Options in Allergy - September 15, 2018 Category: Allergy & Immunology Source Type: research

Contact Urticaria and Protein Contact Dermatitis —a Frequently Hidden Diagnosis
AbstractPurpose of reviewWe hope that this review can assist in the classification, diagnosis, prevention, and treatment of a contact urticaria syndrome (CUS), a syndrome in which the understanding of such is still evolving.Recent findingsCUS and protein contact dermatitis (PCD) can be defined as an immediate inflammatory reaction of the skin following contact with an external substance. Erythema, wheals, and eczema, as well as other manifestations can occur as a result of this inflammatory reaction. Many low molecular weight substances and proteins are known to produce these immediate skin contact reactions. These reactio...
Source: Current Treatment Options in Allergy - September 1, 2018 Category: Allergy & Immunology Source Type: research

Mechanism of Synthetic Peptide Immuno-Regulatory Epitopes and Their Clinical Efficacy in the Treatment of Allergic Disease
AbstractPurpose of reviewPeptide immunotherapy with synthetic peptide immuno-regulatory epitopes (SPIREs) is a safer alternative to conventional allergen immunotherapy (AIT) owing to the reduced risk of IgE-mediated adverse reactions and shorter treatment schedules. Over the last 5  years, significant advances have been made in evaluating SPIREs for the treatment of allergic rhinitis. This review includes a summary of recent phase II and III clinical trials evaluating the efficacy of SPIREs and a brief discussion on their mechanism of action.Recent findingsTo date, SPIREs have been developed for cat, house dust mite (HDM)...
Source: Current Treatment Options in Allergy - September 1, 2018 Category: Allergy & Immunology Source Type: research

Duration of Allergen Immunotherapy for Long-Term Efficacy in Allergic Rhinoconjunctivitis
AbstractRationaleSubcutaneous and sublingual immunotherapy are effective for allergic rhinitis. An important question is whether allergen immunotherapy provides a sustained clinical effect after treatment cessation. In view of potential side effects, cost and the necessary patient commitment, long-term benefit is an important consideration for the recommendation of immunotherapy over standard pharmacotherapy.Purpose of reviewIn this review, we analyse the existing evidence for long-term effects of both routes of administration in the context of double-blind, placebo-controlled, randomised clinical trials that included a fo...
Source: Current Treatment Options in Allergy - September 1, 2018 Category: Allergy & Immunology Source Type: research

Correction to: The Association Between Ambient Air Pollution and Allergic Rhinitis Inception and Control
Unfortunately, the original publication of this article contained mistakes. The publisher introduced an error after proofreading where the family name of the co-author was mistakenly captured as “Fenández Caldas”. The correct family name should be “Fernández-Caldas”.
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research

Allergic Rhinitis and Other Atopic Diseases in Children With Attention Deficit Hyperactivity Disorder
AbstractPurpose of reviewAttention deficit hyperactivity disorder (ADHD) and allergic rhinitis (AR) constitute high-prevalence entities in the pediatric population, and both affect the quality of life of children and their families. Over the last decade, it has been stated that a high number of patients with ADHD show comorbidities with allergic diseases. The aim of this review is to assess the current information about the relationship between both entities.Recent findingsAccording to some authors, a causal association between them has been proposed since they have genetic, environmental, and inflammatory physiopathologic...
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research

An Update on the Management of Anaphylaxis
AbstractPurpose of reviewTo highlight the latest evidence supporting management recommendations in anaphylaxis and discuss the implications for further research in anaphylaxis management.Recent findingsThe acute management of anaphylaxis is largely centered on resuscitation and administration of epinephrine. There is little evidence to support the use of antihistamines and corticosteroids in the acute management of anaphylaxis.SummaryAnaphylaxis is an acute, systemic, potentially life-threatening reaction caused by the release of mast cell and basophil mediators that could lead to distributive shock. Anaphylaxis is associa...
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research

Diagnosis and Management of Allergic Conjunctivitis
AbstractPurpose of the reviewThe purpose of this review is to define the classification, diagnosis, and management in adults and children with allergic conjunctivitis with emphasis on recent findings.Recent findingsCurrent literature divides allergic conjunctivitis according to severity and frequency, facilitating its diagnosis, study, and treatment choices. Novel pharmacological therapies aim at inhibiting inflammatory pathways at a specific molecular level and include selective glucocorticoid receptor agonists, kinase inhibitors, and IL-1 receptor antagonists.SummaryOcular allergies are a group of heterogeneous diseases ...
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research

Risk Factors and Cofactors for Severe Anaphylaxis
AbstractPurpose of reviewSevere anaphylaxis is a generalized reaction in which cardiovascular and respiratory involvement lead to a fatal or near-fatal outcome. Triggers of severe anaphylaxis differ from one age group to another and are mostly represented by drugs and hymenoptera stings in adults and food in children. Several risk factors and cofactors can increase the odds of severe anaphylaxis by different and still undefined mechanisms.Recent findingsMajor risk factors for severe anaphylaxis include old age, male sex, and preexisting medical conditions such as mast cell disorders, cardiovascular diseases, and uncontroll...
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research

Impact and Assessment of Sleep Disturbance in Adults and Children with Allergic Rhinitis
AbstractPurpose of ReviewIn this article, we review the impact and the treatment of sleep disturbance caused by allergic rhinitis (AR) in adult and pediatric patients.Recent FindingsAlthough intranasal corticosteroids (INS) remain the mainstay treatments for AR-induced sleep disturbance, allergen immunotherapy (AIT) has been suggested to be effective in altering the course and progression of moderate-to-severe AR that is refractory to pharmacotherapy. MP-AzeFlu is a recently developed formulation containing azelastine, an intranasal antihistamine (INAH), and fluticasone propionate, an INS. MP-AzeFlu has been reported to ha...
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research

ARIA 2017: a Review of Major Changes and Innovations
ConclusionARIA guideline has evolved to a technology-based implementation strategy to help rhinitis sufferers to have an active and healthy life and to reduce health and social inequalities caused by this very common disease, irrespective of their age, sex, or socio-economic status.
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research

Food-Dependent Exercise-Induced Anaphylaxis
AbstractPurpose of reviewFood-dependent exercise-induced anaphylaxis (FDEIA) is a form of anaphylaxis that occurs associated with exercise, in which symptoms develop by the combination of food ingestion and physical activity. We aimed to review and discuss the main clinical recommendations for management of FDEIA, focusing on individual factors.Recent findingsNew diagnostic strategies have been developed to optimize the accuracy of provocation challenges, taking in consideration augmenting factors, such as alcohol or non-steroidal anti-inflammatory drugs. However, FDEIA is still insufficiently diagnosed and a high index of...
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research

The Association Between Ambient Air Pollution and Allergic Rhinitis Inception and Control
This article summarizes the main consequences of the complex relationship that exists between allergic rhinitis, environmental pollution, and climate change and presents some potential measures aiming at modifying some aspects of this intriguing relationship to achieve a clinical benefit in patients suffering from allergic diseases, especially allergic rhinitis.
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research