Filtered By:
Source: Current Treatment Options in Allergy

This page shows you your search results in order of relevance. This is page number 11.

Order by Relevance | Date

Total 345 results found since Jan 2013.

Drug-Induced Anaphylaxis
Opinion statement Drug-induced anaphylaxis can be a life-threatening condition occurring after drug intake by any route, including non-therapeutic exposure due to accidental contact. The most common culprit drugs are non-steroidal anti-inflammatory drugs and beta-lactam antibiotics. Other antibiotics, such as quinolones, are also becoming important elicitors. In the hospital setting, neuromuscular blocking agents and contrast media play an important role. In addition to specific immunological mechanisms (IgE-mediated), other non-immunological mechanisms may participate, including the generation of vasoactive media...
Source: Current Treatment Options in Allergy - June 2, 2015 Category: Allergy & Immunology Source Type: research

Cosmetic Habits and Cosmetic Contact Dermatitis in Children
Abstract Allergic contact dermatitis from cosmetics in children and adolescents has recently become more frequently observed and recognized. Fragrances, hair dyes, sunscreen agents, and preservative agents, particularly methylisothiazolinone, are the most frequently reported contact allergens.
Source: Current Treatment Options in Allergy - June 5, 2015 Category: Allergy & Immunology Source Type: research

Idiopathic Anaphylaxis—A Diagnostic and Therapeutic Dilemma
Opinion statement Idiopathic anaphylaxis is a diagnosis of exclusion which falls in the spectrum of mast cell activation disorders. The role of bone marrow biopsy remains controversial, but in the appropriate clinical context, this diagnostic tool may be useful in ruling out a potential systemic mast cell process. There is no definitive treatment for idiopathic anaphylaxis, but omalizumab and rituximab show a promising role in prevention. At this time, data suggesting a role for these two monoclonal antibodies come from case reports but do not prove causation or efficacy of therapy. Clinical trials further investi...
Source: Current Treatment Options in Allergy - June 24, 2015 Category: Allergy & Immunology Source Type: research

Rapid Desensitization in Immediate Hypersensitivity Reaction to Drugs
Opinion Statement Adverse drug reactions have increased dramatically worldwide, often preventing the use of first-line therapies. Not infrequently, many patients presenting with drug hypersensitivity reactions are irreversibly labeled as allergic, fact that prevents them to receive the most appropriate treatment for their illnesses. Rapid drug desensitization has become a cornerstone in the management of immediate drug hypersensitivity reactions. It is the only effective procedure for overcoming hypersensitivity reactions to first-line therapy, thus representing an important advance in patients’ treatment and pr...
Source: Current Treatment Options in Allergy - June 24, 2015 Category: Allergy & Immunology Source Type: research

How to Diagnose and Manage Systemic Autoinflammatory Diseases in Childhood
Opinion statement Systemic autoinflammatory diseases (sAIDs) are severe disabling conditions associated with a significant morbidity and limited awareness. Cryopyrin-associated periodic syndrome (CAPS) and systemic juvenile idiopathic arthritis (sJIA) are two prototype sAIDs that present with chronic urticarial or maculo-papular rash in early childhood. A diagnosis of sAID relies on combined clinical symptoms, a positive family history, where applicable, and typical laboratory results. Treatment with anti-cytokine blockers targeting interleukin-1 (IL-1) or IL-6 is effective in reducing clinical symptoms and inflam...
Source: Current Treatment Options in Allergy - July 1, 2015 Category: Allergy & Immunology Source Type: research

Review of Occupational Contact Dermatitis—Top Allergens, Best Avoidance Measures
Opinion statement Occupational contact dermatitis accounts for a significant proportion of occupational disease. Although dermatitis can occur anywhere on the body, hands are the most frequently affected location. Long-term or repetitive exposure to allergens and irritants can lead to chronic dermatitis resulting in significant reduction in quality of life. The first-line treatment for both irritant and allergic contact dermatitis is irritant and allergen avoidance. Modification of diet and lifestyle may be necessary to reduce exposures to certain substances. Well-established and user-friendly electronic databases...
Source: Current Treatment Options in Allergy - September 30, 2015 Category: Allergy & Immunology Source Type: research

The Role of Mast Cells Mediators in Angioedema Without Wheals
Opinion statement Angioedema is defined as localized and transient edema of the deep skin layers or the upper respiratory or gastrointestinal mucosa. Although the most common sites of involvement are the tongue, lips, face, and throat, angioedema may also occur in the extremities, genitalia, and viscera, and it can be life-threatening when affecting the upper airway. Angioedema is due to a temporary increase of the vascular permeability caused by vasoactive mediators. However, the mechanisms and the mediators involved in angioedema without wheals vary depending on the type of angioedema. The purpose of this review...
Source: Current Treatment Options in Allergy - October 7, 2015 Category: Allergy & Immunology Source Type: research

Avocational Contact Dermatitis—Pearls for Recognition and Management
Opinion Statement Avoidance is the principle treatment for all types of contact dermatitis. The myriad of potential hobbies and recreational activities can make recognizing and managing avocational contact dermatitis challenging. For this reason, it is important to become familiar with some of the more common irritants and allergens encountered. Key Points 1. An avocation is a recreational activity or hobby which may lead to exposure of potential cutaneous irritants and allergens. 2. Many cases of avocational contact dermatitis present as hand dermatitis. 3....
Source: Current Treatment Options in Allergy - October 13, 2015 Category: Allergy & Immunology Source Type: research

Another Great Imitator: Allergic Contact Dermatitis Differential Diagnosis, Clues to Diagnosis, Histopathology, and Treatment
Opinion statement Allergic contact dermatitis (ACD) is a type IV (delayed) hypersensitivity reaction that has a wide spectrum of presentations that often imitate or overlap with other cutaneous eruptions. Differential diagnoses to consider include infections, skin lymphoma-malignancies, inflammatory dermatoses, nutritional deficiencies, and mechanical causes of tissue damage. We discuss clues to the diagnosis of ACD, such as pruritus, localization to the area of skin contact with the allergen, recurrence with repeat exposures, and supportive skin biopsy histology. Epicutaneous patch testing remains the gold standa...
Source: Current Treatment Options in Allergy - October 16, 2015 Category: Allergy & Immunology Source Type: research

Review of Contact Urticaria Syndrome—Evaluation to Treatment
Source: Current Treatment Options in Allergy - October 17, 2015 Category: Allergy & Immunology Source Type: research

Coagulation in Chronic Urticaria
Opinion statement There is increasing evidence that the coagulation cascade may play a role in the pathophysiology of chronic urticaria, particularly in severely active forms. Although anticoagulant therapy is presently not included among the standard treatments of severe chronic urticaria, based on the limited, but encouraging, literature presently available either warfarin or heparin could be considered as an add-on therapy in severely affected patients that do not respond to either antihistamines, omalizumab or ciclosporin, showing elevated plasma levels of D-dimer.
Source: Current Treatment Options in Allergy - October 20, 2015 Category: Allergy & Immunology Source Type: research

Cosmeceutical Contact Dermatitis—Cautions To Herbals
This article aims to emphasize risks associated with use of cosmetics marketed as “natural” and to review specific botanical allergens implicated in causing allergic contact dermatitis. Key points 1. Allergic contact dermatitis (ACD) is a type IV (delayed) hypersensitivity reaction which can occur to naturally derived products.2. Extracts derived from Compositae plants, propolis, and limonene, along with a number of essential oils and waxes, are popular in cosmetics and serve as botanical sources increasingly implicated in causing adverse skin reactions.3. Pinpointing the allergen...
Source: Current Treatment Options in Allergy - November 20, 2015 Category: Allergy & Immunology Source Type: research

Pre-Coseasonal vs Perennial Sublingual Immunotherapy for Seasonal Allergens Dosing Regimen: Long-Term Benefits, Adherence, and Cost-Effectiveness—Is There a Difference?
Opinion statement Allergen immunotherapy (AIT) is to date the only disease-modifying and etiological treatment for IgE-mediated respiratory allergies. In France and Italy, the main route of administration of AIT for respiratory allergies is currently constituted by sublingual allergen immunotherapy (SLIT). In other European countries, the marketing is growing. In the USA, SLIT is increasingly taking hold, too. Various SLIT regimens have been employed to date for respiratory allergies induced by pollen, which constitutes a major atopic sensitizer in Europe and North America: continuous (all year-round), pre-seasona...
Source: Current Treatment Options in Allergy - January 29, 2016 Category: Allergy & Immunology Source Type: research

Novel Allergen Immunotherapy Routes
Opinion statement Allergic diseases are among the most common human diseases of humans. Approximately 33 % of the total population in industrialized countries may be affected. The immune response towards allergens is regulated by T lymphocytes and characterized by an interleukin (IL)-4, IL-5 and IL-13 dominated Th2 cytokine profile. Allergen-specific immunotherapy (AIT) is the only causative treatment option and able to change the natural course of disease, e.g., to prevent the development of asthma and new sensitizations. Classically, the allergen extract has been applied subcutaneously to the patient. New appli...
Source: Current Treatment Options in Allergy - January 28, 2016 Category: Allergy & Immunology Source Type: research

Non-Allergic Rhinitis
Opinion statement A cardinal aspect of treating non-allergic rhinitis is inherent difficulties in diagnosis and classification, due to its heterogeneity. Thus, optimal treatment can vary significantly. Lifestyle modifications can be the treatment of choice in several subtypes (e.g., occupational or gustatory rhinitis), whereas other subtypes respond very well to intranasal corticosteroids (e.g., non-allergic rhinitis with eosinophilia), intranasal antihistamines or novel treatment modalities as TRPV1 inhibitors. Combination of intranasal fluticasone propionate together with azelatine has recently proved to be bett...
Source: Current Treatment Options in Allergy - February 5, 2016 Category: Allergy & Immunology Source Type: research